Licensure and Personnel
22%of exam
Pharmacist Practice
33%of exam
Dispensing Requirements
24%of exam
Pharmacy Operations
21%of exam
Quick Facts
- Exam
- MPJE
- Body
- NABP
- Items
- 120 (100 scored)
- Time
- 2.5 hours
- Format
- Adaptive, Pearson VUE
- Result
- Pass/Fail only
- Minimum answered
- 107 items
- Largest area
- Pharmacist Practice 33%
- Blueprint
- Through Feb 28, 2027
- Retake
- 30 days, five max
- Fees
- $100 application + $170 exam
- Scope
- Federal plus jurisdiction law
MPJE vs UMPJE
MPJE
- State-specific law exam
- Used since 1998
- Separate attempt per jurisdiction
UMPJE
- Uniform common-principles exam
- Launched 2026
- 13 boards adopted
State-specific vs uniform exam
Federal or State Rule?
- Federal and state conflict→Apply the stricter rule(Satisfy both)
- Pharmacist-in-charge duties→State law(No federal PIC)
- Technician ratios→State law
- PMP query requirement→State law(Not federal)
- CV refill cap→State law(No federal cap)
- Record retention beyond two→State law(Federal floor 2 years)
- Immunization authority→State law
- DEA form or schedule→Federal law(Uniform nationwide)
DEA Registration Basics
- Registrant
- Pharmacy, not pharmacist
- Pharmacist role
- Agent of the registrant
- Pharmacy term
- Three-year cycle
- Manufacturer term
- Annual renewal
- Scope
- One per business location1301.12
- Storage-only warehouse
- Exempt from separate registration
- Transfer of registration
- Never transferable
- Address change
- Free modification, number kept
- Expired registration
- No controlled handling allowed
- Prefix A/B/F/G
- Hospital, pharmacy, practitioner, teaching
- Prefix M
- Mid-level practitioner
- Check digit
- Odd sum plus twice evens
- X-waiver
- Retired; CIII authority suffices
Personnel and POA
- Power of attorney
- Signs Form 222 orders
- POA signer
- Same as registration signer
- POA filing
- Kept onsite, never mailed
- Non-pharmacist POA
- Permitted
- POA revocation
- Any time, in writing
- Pharmacist-in-charge
- State creation, not federal
- Technician ratios
- State law only
- Employee screening
- Felony drug inquiry, 5 years1301.90
- Diversion reporting
- Encouraged, not mandated
Score and Retake Rules
- Result reporting
- Pass or Fail only
- Scaled score
- None since 2021
- Minimum answered
- 107 of 120
- Under 107 answered
- No result reported
- 107 to 119
- Penalty per unanswered item
- Skipping items
- Not possible; adaptive
- Retake wait
- 30 days
- Attempt cap
- Five per jurisdiction
- Score portability
- None between jurisdictions
- Failing report
- Competency-area breakdown given
Blueprint Weights
33 Practice, 24 Dispensing, 22 Licensure, 21 Operations
Pharmacist Practice 33%Dispensing Requirements 24%Licensure/Personnel 22%Pharmacy Operations 21%
CII vs CIII-CV Refills
CII
- No refills ever
- Separate 90-day prescriptions
- Emergency oral needs 7-day cover
CIII-CV
- Five refills maximum
- Six months from issue
- CV has no federal cap
CII never refills; others limited
CSA Schedules
- CI
- No accepted medical use
- CI examples
- Heroin, LSD
- CII
- Oxycodone, fentanyl, amphetamine
- CIII
- Buprenorphine, ketamine, anabolic steroids
- CIV
- Benzodiazepines, tramadol, zolpidem
- CV
- Pregabalin, low-dose codeine syrup
- CI test
- Lack of accepted use
- Methadone for OUD
- Certified treatment program only
OBRA-90 Trio
ProDUR, offer to counsel, patient records
Prospective DUROffer, not counselingPatient medication recordsEffective 1993
Agent vs Prescriber
Agent
- May prepare prescription
- May transmit prescription
- Never signs it
Prescriber
- Signs manually
- Holds DEA registration
- Owns prescribing responsibility
Agents transmit; prescribers sign
Controlled Rx Elements
- Date of issue
- Required1306.05
- Patient name
- Full name required
- Patient address
- Required on controlled prescriptions
- Drug detail
- Name, strength, form, quantity
- Directions
- Explicit, not as-directed
- Prescriber DEA number
- Required
- Prescriber identity
- Name and address
- Signature
- Manual, on issue date
- Agent limits
- May prepare, never sign
- Legitimate purpose
- Usual course of practice1306.04
- EPCS authentication
- Two of three factors
- EPCS printing
- Cannot print then sign
Refills and Quantity Limits
- CII refills
- Never permitted1306.12
- CII 90-day supply
- Multiple separate prescriptions
- Do-not-fill-before
- Earliest fill date noted
- CIII-CIV refills
- Five refills, six months1306.22
- Six-month clock
- Starts at date written
- CV refills
- As authorized, no federal cap
- Emergency oral CII
- Emergency-period quantity only1306.11
- Emergency cover script
- Signed writing within 7 days
- Cover script missing
- Notify DEA field office
- Pharmacist CII changes
- Consult prescriber, document agreement
- Never changeable
- Patient name, drug, signature
OBRA-90 and HIPAA
- OBRA-90 effective
- January 1, 1993
- OBRA-90 lever
- Medicaid funding condition
- Three duties
- ProDUR, offer, patient records
- Federal duty
- Offer to counsel
- Counseling elements
- Eight content items
- Not an element
- Price
- Refusal handling
- Document patient response
- HIPAA TPO
- Treatment, payment, operations
- Minimum necessary
- Not for treatment disclosures
- Breach notice
- 60 days from discovery
- Breach of 500
- HHS and media notice
- Small breaches
- Annual log to HHS
Partial Fill Days
72 hours, 30 days, 60 days
72 hours: stock shortage30 days: requested partial60 days: LTCF or terminal
Transfer vs Initial-Fill Forward
Transfer
- Refill information moves
- Schedules III-V
- One time only
Forward
- Unfilled prescription moves
- Electronic CII-CV
- Patient request, before dispensing
Refills transfer; unfilled forwards
Can This CII Be Partial-Filled?
- Stock short today→Fill available quantity(Remainder 72 hours)
- Not supplied in 72 hours→Notify prescriber(New prescription needed)
- Patient requests partial→Partial allowed(30 days total)
- Prescriber requests partial→Partial allowed(30 days total)
- Long-term-care resident→Partial allowed(60 days)
- Documented terminal illness→Partial allowed(60 days)
- Schedule III-V prescription→Partial allowed(Six-month limit)
- Total exceeds quantity prescribed→Not allowed(Hard cap)
Partial Fills and Transfers
- CII stock shortage
- Remainder within 72 hours1306.13
- After 72 hours
- Notify prescriber; balance void
- CARA partial fill
- 30 days from issue
- Who may request
- Patient or prescriber
- LTCF resident
- 60 days from issue
- Terminal illness
- 60 days, documented
- CIII-CV partial
- Recorded like a refill1306.23
- Partial total
- Never exceeds quantity prescribed
- CIII-CV transfer
- One time only1306.25
- Shared live database
- Remaining refills transferable
- Transfer parties
- Pharmacist to pharmacist
- CII transfer
- Electronic, initial fill only
- Transfer records
- Both pharmacies, 2 years
CV OTC Limits
Opium 240 mL, other 120 mL, 48 hours
Opium 240 mLOpium 48 dosage unitsOther CV 120 mLOther CV 24 unitsPurchaser 18+
Misbranding vs Adulteration
Misbranded
- Labeling defect
- Missing Rx-only legend
- Dispensed without valid prescription
Adulterated
- Product defect
- Contamination or wrong strength
- Insanitary conditions
Label vs product
How Do I Handle This Transfer?
- CIII-CV refills remain→One transfer only(Pharmacist to pharmacist)
- Shared real-time database→Transfer remaining refills(Exception)
- CII electronic, never dispensed→One forward allowed(Initial fill)
- CII paper or oral→No transfer(Electronic only)
- CII already partly dispensed→No transfer(Window closed)
- Printing the electronic script→Not allowed(Must stay electronic)
- Recording the transfer→Both pharmacies retain(2 years)
- Non-controlled prescription→State law governs(Varies widely)
OTC Limits and Packaging
- CMEA daily limit
- 3.6 g base
- CMEA 30-day limit
- 9 g base
- CMEA mail order
- 7.5 g per 30 days
- CMEA storage
- Behind counter or locked
- CMEA logbook
- Retained 2 years
- CMEA ID
- Photo identification required
- CV opium OTC
- 240 mL, 48 units1306.26
- CV other OTC
- 120 mL, 24 units
- CV OTC window
- Same purchaser, 48 hours
- CV OTC age
- 18 or older
- CV OTC seller
- Pharmacist must dispense
- PPPA agency
- Consumer Product Safety Commission
- PPPA exemptions
- Sublingual nitroglycerin, oral contraceptives
- More PPPA exemptions
- Pancrelipase, low-dose prednisone
Prescriber vs Patient Waiver
Prescriber
- One prescription only
- Per-order authorization
- Cannot be blanket
Patient
- Blanket waiver allowed
- Covers all prescriptions
- Signed request
Prescriber single; patient blanket
Labeling and Validity
- Transfer warning
- Required on CII-CIV290.5
- CV warning
- Exempt
- DEA label items
- Fill date, pharmacy, serial
- More label items
- Patient, prescriber, directions
- Corresponding responsibility
- Pharmacist shares prescribing duty
- Red flags
- Cash, distance, cocktails, early
- Red flag action
- Resolve and document first
- Misbranding
- Labeling or information defect
- Adulteration
- Defect in the product
- ProDUR screens
- Duplication, interaction, dose, allergy
- PMP query
- State duty, not federal
DEA Form Ladder
224 apply, 222 order, 106 lose, 41 destroy
224 apply224a renew222 order CII106 theft or loss41 destroy223 certificate363 treatment program
503A vs 503B Compounding
503A
- Patient-specific prescription
- State board oversight
- USP standards, cGMP exempt
503B
- No prescription needed
- FDA registered and inspected
- cGMP required
Prescription vs cGMP
Which DEA Form?
- Registering a new pharmacy→Form 224
- Renewing the registration→Form 224a
- Manufacturer or distributor→Form 225
- Narcotic treatment program→Form 363
- Ordering CII stock→Form 222 or CSOS
- Ordering CIII-CV stock→Invoice(Keep 2 years)
- Theft or significant loss→Form 106(Written notice first)
- Destroying controlled stock→Form 41(Two witnesses)
- Giving up the registration→Form 104
- Proving registration onsite→Form 223(Certificate)
- Illegitimate DSCSA product→FDA Form 3911(24 hours)
DEA Forms Quick Map
- Form 222
- Order CI-CII on paper
- CSOS
- Electronic CI-CII ordering
- CIII-CV ordering
- Invoice only, no 222
- Form 224
- New pharmacy registration
- Form 224a
- Renewal only
- Form 225
- Manufacturer, distributor, researcher
- Form 363
- Narcotic treatment program
- Form 223
- Certificate of registration
- Form 106
- Theft or significant loss
- Form 41
- Destruction record
- Form 104
- Voluntary surrender
- FDA Form 3911
- Illegitimate product notification
Retention Windows
DEA 2, DSCSA 6, CMEA 2
DEA records 2 yearsDSCSA statements 6 yearsCMEA logbook 2 yearsState may require longer
Form 106 vs Form 41
Form 106
- Theft or significant loss
- Written notice, one business-day
- DEA Field Division
Form 41
- Destruction record
- Non-retrievable standard
- Two employee witnesses
Loss vs destruction
Records and Inventory
- DEA retention
- 2 years minimum
- Record location
- Registered site, readily retrievable
- CII records
- Filed separately
- CIII-CV records
- Separate or readily retrievable
- Initial inventory
- First day handling controls
- Biennial inventory
- Every 2 years
- Inventory timing
- Opening or close stated
- CII count
- Exact count required
- CIII-CV count
- Estimate; exact over 1,000 opened
- Form 222 execution
- One item per line
- Form 222 errors
- Mark void, keep it
- Theft notice
- Written, one business day
- In-transit loss
- Supplier reports until signed
- DSCSA retention
- 6 years
Security, Compounding, Supply
- Storage option one
- Locked substantial cabinet1301.75
- Storage option two
- Dispersed through stock
- 503A
- Patient-specific prescription required
- 503A cGMP
- Exempt; follows USP
- 503B
- FDA-registered outsourcing facility
- 503B cGMP
- Required
- DSCSA partners
- Authorized trading partners only
- Suspect product
- Quarantine and investigate
- Illegitimate product
- Notify FDA within 24 hours
- Return to stock
- Generally prohibited
- PDMA samples
- Never sold, purchased, traded
- Destruction standard
- Non-retrievable, two witnesses
Common Traps
Scaled 75 is legacy
Reported Pass or Fail ≠ No scaled score since 2021
107 items, not 120
107 answered gets result ≠ Under 107 gets nothing
72 hours vs 30 days
72 hours: stock shortage ≠ 30 days: requested partial
Six-month clock start
Runs from date written ≠ Not from first fill
DEA 2 years vs DSCSA 6
Controlled records 2 years ≠ DSCSA statements 6 years
Form 106 vs Form 41
106 reports theft/loss ≠ 41 records destruction
CV label warning exempt
Warning on CII-CIV ≠ Schedule V exempt
CV OTC age is 18
Purchaser must be 18 ≠ Not 21
PPPA is CPSC, not FDA
CPSC administers PPPA ≠ FDA does not
MPJE is not UMPJE
MPJE is state-specific ≠ UMPJE is uniform, separate
Pharmacists hold no DEA number
Pharmacy is the registrant ≠ Pharmacist acts as agent
503B is not cGMP-exempt
503B must meet cGMP ≠ Only new-drug approval exempt
Last Minute
- 1.Weights: licensure 22, practice 33
- 2.Weights: dispensing 24, operations 21
- 3.Result is Pass or Fail
- 4.Answer at least 107 questions
- 5.Retake after 30 days; five max
- 6.CII prescriptions never refill
- 7.CIII-CIV: 5 refills, 6 months
- 8.Six-month clock starts when written
- 9.Partial CII shortage: 72 hours
- 10.Requested CII partial: 30 days
- 11.LTCF or terminal partial: 60 days
- 12.Emergency oral CII: written 7 days
- 13.Form 222 covers CI-CII orders
- 14.Form 106 theft; Form 41 destruction
- 15.DEA records 2 years; DSCSA 6
- 16.Pseudoephedrine 3.6 g daily, 9 monthly
- 17.Schedule V opium OTC: 240 mL
- 18.Other Schedule V OTC: 120 mL
- 19.Schedule V OTC purchaser: 18 minimum
- 20.PPPA: prescriber single, patient blanket
- 21.OBRA-90 requires an offer to counsel
- 22.Stricter rule wins, federal or state
Buy on AmazonSame family resources
Explore More MPJE Pharmacy Jurisprudence
Continue into nearby exams from the same family. Each card keeps practice questions, study guides, flashcards, videos, and articles in one place.
More From This Family
Videos and articles for deeper review.