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Free Practice Questions for Philippine Pharmacist Licensure Exam

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Exam Review

Key Facts: Philippine Pharmacist Licensure Exam Exam

6

Official PRC Subjects

PRC April 18-19, 2026 program

20%

Largest Single Weight

Pharmaceutical Chemistry in PRC program

11 hrs

Subject Testing Time

PRC April 2026 program schedule

75%

General Weighted Average

RA 10918

P900

Complete Exam Fee

PRC requirements/FAQ

57.26%

April 2026 Pass Rate

PRC result notice: 1,085 of 1,895

The PRC Pharmacists Licensure Examination is a two-day written board exam. The April 18-19, 2026 program assigns 20% to Pharmaceutical Chemistry, 15% to Pharmacognosy/Biochemistry, 17.5% to Practice of Pharmacy, 15% to Pharmacology-Pharmacokinetics, 17.5% to Pharmaceutics, and 15% to Quality Control/Quality Assurance. RA 10918 requires a 75% general weighted average with no subject below 50%. PRC publishes the fee as P900.00 for a complete baccalaureate licensure examination; the public program does not publish a current total question count, so that field is marked pending.

Sample Philippine Pharmacist Licensure Exam Practice Questions

Try these sample questions to review concepts for the Philippine Pharmacist Licensure Exam exam. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.

1Which statement best describes the ionization of a weak acid drug when the pH is higher than its pKa?
A.The drug is mostly unionized and less water-soluble
B.The drug is mostly ionized and more water-soluble
C.The drug is converted into a strong base
D.The drug has no ionized form at any pH
Explanation: For a weak acid, pH above pKa favors the deprotonated A- form. That form is ionized, usually more water-soluble, and generally less able to diffuse across lipid membranes than the unionized HA form.
2In qualitative pharmaceutical analysis, which reagent is classically used to precipitate chloride ions as a white precipitate?
A.Ferric chloride
B.Silver nitrate
C.Barium chloride
D.Potassium permanganate
Explanation: Silver nitrate reacts with chloride to form silver chloride, a white precipitate that darkens on exposure to light. This is a common inorganic qualitative test concept for halide identification.
3Which functional group in penicillins is most directly responsible for their beta-lactam activity and also vulnerable to beta-lactamase hydrolysis?
A.Aromatic nitro group
B.Four-membered cyclic amide
C.Sulfonamide group
D.Glycosidic bond
Explanation: Penicillins contain a beta-lactam ring, which is a strained four-membered cyclic amide. Opening this ring destroys antibacterial activity because the drug can no longer acylate the bacterial transpeptidase target effectively.
4Aspirin is more prone than salicylic acid to hydrolysis because aspirin contains which hydrolyzable group?
A.Ester
B.Amide
C.Ether
D.Tertiary amine
Explanation: Aspirin is acetylsalicylic acid and contains an ester linkage that can hydrolyze to salicylic acid and acetic acid. Moisture, heat, and alkaline conditions can accelerate this degradation.
5Which interaction explains why tetracycline absorption decreases when taken with milk or antacids?
A.Covalent acetylation by lactose
B.Chelation with multivalent cations
C.Oxidation by gastric acid
D.Conversion into a beta-lactam
Explanation: Tetracyclines chelate calcium, magnesium, aluminum, iron, and other multivalent cations. The resulting complexes are poorly absorbed, so separation from dairy, iron, and many antacids is clinically important.
6Which property generally increases a drug's ability to cross lipid membranes by passive diffusion?
A.Higher unionized fraction
B.Higher permanent charge
C.Complete conversion to salt in solution
D.Very large molecular size
Explanation: Unionized molecules usually partition more readily into lipid membranes than ionized molecules. This is why pH-pKa relationships matter for absorption, distribution, and formulation decisions.
7Which structural change would usually increase the duration of action of a catecholamine against COMT metabolism?
A.Adding a second phenolic hydroxyl group
B.Removing one catechol hydroxyl group
C.Adding a free carboxylic acid only
D.Converting the amine to an amide with no receptor activity
Explanation: Catechol-O-methyltransferase acts on catechol rings, which have adjacent phenolic hydroxyl groups. Removing one of those hydroxyls can reduce COMT metabolism and may prolong activity for sympathomimetic drugs.
8In the Henderson-Hasselbalch relationship for a weak base, what happens as pH falls well below the pKa?
A.The base becomes mostly unionized
B.The base becomes mostly protonated and ionized
C.The pKa becomes zero
D.The drug decomposes immediately
Explanation: A weak base accepts a proton in acidic conditions, forming the ionized BH+ species. This can increase water solubility but often lowers passive lipid diffusion compared with the free base.
9Ferric chloride commonly produces a colored complex with which functional group?
A.Phenol
B.Alkane
C.Ether with no other donor atoms
D.Saturated hydrocarbon chain
Explanation: Ferric chloride can form colored complexes with phenolic compounds. This is useful as a qualitative test concept for drugs or natural products containing phenolic hydroxyl groups.
10Which structural feature distinguishes codeine from morphine and helps explain codeine's lower direct analgesic potency?
A.Codeine has a methyl ether where morphine has a phenolic hydroxyl
B.Codeine has a beta-lactam ring
C.Codeine lacks any aromatic ring
D.Codeine contains a sulfonamide group
Explanation: Codeine is the 3-methyl ether of morphine. The masked phenolic hydroxyl reduces direct receptor interaction, and part of codeine's analgesic effect depends on metabolic O-demethylation to morphine.

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