3.5 Human Anatomy & Physiology: Cells, Tissues, Body Systems & Facial Structures

Key Takeaways

  • The NIC outlines list four tissue types (epithelial, connective, nerve, and muscular), and the skin is the body's largest organ.

  • The trigeminal nerve (cranial nerve V) carries sensation from the face, while the facial nerve (cranial nerve VII) controls the muscles of facial expression.

  • A muscle's origin is its fixed attachment and its insertion is the movable attachment; microcurrent lifting and lengthening techniques are described by moving between them.

  • The orbicularis oculi closes the eyelid, the corrugator draws the brows down and together, and the platysma depresses the lower jaw and lip.

  • The common carotid artery divides into the internal and external carotid arteries, and the external carotid's facial and superficial temporal branches supply the face.

Last updated: October 2026

Why Anatomy Appears on the Exam

The NIC Esthetics Combined Practice outline asks candidates to "demonstrate a basic understanding of human physiology and anatomy related to" cells, tissues, organs, and body systems. Advanced Practice questions use the same knowledge indirectly: lymphatic drainage follows neck anatomy, microcurrent moves along muscles, and contraindications depend on the heart, nerves, and hormones.

Cells

The cell is the basic unit of all living things. Each cell has:

  • a cell membrane that controls what enters and leaves;
  • cytoplasm, the watery fluid where cell work takes place;
  • a nucleus that holds the genetic material (DNA) and controls cell activity; and
  • organelles such as mitochondria, which produce the cell's energy (ATP).

Cells grow and reproduce by mitosis, in which one cell divides into two identical daughter cells. Metabolism is the sum of a cell's chemical processes: anabolism builds larger molecules and stores energy, and catabolism breaks molecules down and releases energy. In the skin, mitosis takes place in the basal layer (section 3.1).

The Four Tissue Types

TissueFunctionSkin and esthetics examples
EpithelialCovers and lines surfaces and forms glandsEpidermis, lining of sweat and sebaceous glands
ConnectiveSupports, binds, and protectsDermis (collagen and elastin), adipose tissue, blood, bone
MuscularContracts to produce movementFacial expression muscles, arrector pili, heart
NerveCarries messages to and from the brainSensory nerve endings in the dermis

Organs and Body Systems

An organ is a structure made of two or more tissue types that performs a specific job, such as the skin, heart, lungs, brain, liver, kidneys, and stomach. The skin is the largest organ of the body. Organs work together in body systems:

SystemMain organsWhy it matters to an esthetician
IntegumentarySkin, hair, nails, glandsThe organ you treat
SkeletalBones, jointsBony landmarks guide massage and device placement
MuscularMusclesMassage, microcurrent, and facial expression lines
NervousBrain, spinal cord, nervesSensation, pain, and seizure-related contraindications
Circulatory (cardiovascular)Heart, arteries, veins, capillariesErythema, heat, and pacemaker-related contraindications
Lymphatic and immuneLymph vessels, nodes, spleenLymphatic drainage, healing, and infection defense
EndocrineGlands that secrete hormonesAcne, melasma, healing, and sensitivity changes
DigestiveStomach, intestines, liverNutrition for skin repair
ExcretoryKidneys, bladder, skin, lungs, large intestineThe skin excretes water and salts in sweat
RespiratoryLungs, airwaysOxygen supply; sensitivity to aerosols and fragrance
ReproductiveOvaries, testesHormonal effects on sebum and pigmentation

Bones of the Head and Neck

The cranium protects the brain: frontal (forehead), two parietal, two temporal, occipital (back of the skull), sphenoid, and ethmoid. The facial skeleton includes two nasal bones, two lacrimal bones near the inner eye, two zygomatic (cheek) bones, two maxillae (upper jaw), and the mandible (lower jaw, the only movable skull bone). The hyoid bone sits in the front of the neck, and seven cervical vertebrae form the neck's spine.

Muscles Estheticians Use Most

A muscle's origin is the more fixed attachment; its insertion is the attachment that moves. Its belly is the middle portion. The microcurrent techniques in section 7.2 describe "lifting" as moving probes from the origin and insertion toward the belly, and "lengthening" as moving from the belly outward. The NIC practical microcurrent task lifts the orbicularis oculi, beginning at the corrugator.

MuscleAction
FrontalisRaises the eyebrows and wrinkles the forehead
CorrugatorDraws the eyebrows down and together (vertical frown lines)
ProcerusPulls the brows down and wrinkles the bridge of the nose
Orbicularis oculiRings the eye and closes the eyelid
Orbicularis orisRings the mouth; closes and puckers the lips
Zygomaticus major and minorPull the corners of the mouth up and out (smiling)
RisoriusDraws the corner of the mouth out and back
BuccinatorCompresses the cheeks (blowing, chewing)
Depressor anguli orisPulls the corners of the mouth down
MentalisRaises and wrinkles the chin
Masseter and temporalisChewing (muscles of mastication)
PlatysmaDepresses the lower jaw and lip; neck bands
Sternocleidomastoid (SCM)Turns and bends the head; a landmark for neck lymphatic work

Nerves of the Face and Neck

  • Trigeminal nerve (cranial nerve V): the chief sensory nerve of the face, with ophthalmic, maxillary, and mandibular branches. It also supplies the chewing muscles.
  • Facial nerve (cranial nerve VII): the chief motor nerve of the face. It emerges near the lower part of the ear and branches (temporal, zygomatic, buccal, marginal mandibular, cervical) to the muscles of expression.
  • Accessory nerve (cranial nerve XI): controls the sternocleidomastoid and trapezius.

Motor points are where a nerve enters a muscle. Light, sub-sensory microcurrent avoids twitching muscles, while galvanic current in milliamperes can stimulate nerves; section 7.2 explains the difference.

Blood Supply

Blood contains red blood cells (carry oxygen), white blood cells (fight infection), platelets (clotting), and plasma (the fluid portion). The common carotid arteries divide into the internal carotid (brain and eyes) and external carotid (face, scalp, neck). External carotid branches include the facial artery (lower face, mouth, nose), the superficial temporal artery (temples and scalp), and the occipital and posterior auricular arteries. Blood returns through the internal and external jugular veins.

Hormones That Change the Skin

  • Androgens increase sebum and drive acne (section 3.3).
  • Estrogen and progesterone affect pigmentation; pregnancy and hormonal contraceptives are classic melasma triggers.
  • Insulin problems (diabetes) slow healing and raise infection risk.
  • Thyroid hormones affect skin dryness, sweating, and hair growth.

Tip

Link each structure to a service: the SCM and thyroid cartilage to lymphatic drainage, the facial nerve to motor points, and the carotid branches to why heat makes the face flush.

Test Your Knowledge

Which list names the four tissue types in the NIC Combined Practice outline?

A

Skin, bone, blood, and lymph

B

Epidermal, dermal, subcutaneous, and fascial

C

Epithelial, connective, nerve, and muscular

D

Collagen, elastin, keratin, and melanin

Test Your Knowledge

A client cannot raise one side of the mouth after an injury near the ear. Which nerve most likely controls the affected muscles?

A

Facial nerve (cranial nerve VII)

B

Accessory nerve (cranial nerve XI)

C

Optic nerve (cranial nerve II)

D

Trigeminal nerve (cranial nerve V)

Test Your Knowledge

Which muscle closes the eyelid and is the target of the microcurrent lift section on the NIC Advanced Practice practical?

A

Orbicularis oris

B

Orbicularis oculi

C

Zygomaticus major

D

Depressor anguli oris

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