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5.2 Integrated Science: Biology, Chemistry, Physics & Earth Science

Key Takeaways

  • Cell biology emphasizes organelle specialization: Mitochondria produce ATP via cellular respiration, Chloroplasts conduct photosynthesis, and Ribosomes synthesize proteins.

  • Mendelian genetics yields predictable phenotypic ratios, such as the 3:1 ratio in a monohybrid cross of heterozygous dominant parents (Aa x Aa).

  • The periodic table displays predictable periodic trends: Electronegativity and Ionization Energy increase up and to the right, whereas Atomic Radius increases down and to the left.

  • Newton's Three Laws of Motion govern classical mechanics: Inertia (1st Law), F = ma (2nd Law), and Action-Reaction (3rd Law).

  • Plate tectonics drives geological processes along convergent, divergent, and transform boundaries, while atmospheric dynamics dictate weather patterns in the Troposphere.

Last updated: July 2026

Integrated Science: Biology, Chemistry, Physics & Earth Science

The General Science component of the ACET spans four major scientific disciplines. Success requires a firm grasp of core vocabulary, foundational equations, biological structures, chemical reactions, physical laws, and Earth system processes.


1. Biological Sciences

Cell Biology & Organelles

All living organisms are composed of cells—prokaryotes (lacking a membrane-bound nucleus, e.g., bacteria) or eukaryotes (containing membrane-bound organelles, e.g., plants, animals, fungi).

OrganelleFunctionKey Characteristic
NucleusStores genomic DNA and controls cellular activitySurrounded by a double-membrane nuclear envelope
MitochondriaGenerates cellular energy (ATP) via aerobic respirationKnown as the "powerhouse of the cell"; contains own mtDNA
RibosomesSite of protein synthesis (translation)Found free in cytoplasm or bound to Rough ER
Endoplasmic Reticulum (ER)Rough ER: protein folding/transport; Smooth ER: lipid synthesis & detoxificationInterconnected network of tubules and sacs
Golgi ApparatusModifies, sorts, and packages proteins for secretionStacks of flattened sacs (cisternae)
ChloroplastsConverts solar energy into chemical energy (glucose)Present in plants/algae; contains chlorophyll

Bioenergetics: Photosynthesis vs. Respiration

  • Photosynthesis Equation: 6CO2+6H2O+Light Energy→ChlorophyllC6H12O6+6O26\text{CO}_2 + 6\text{H}_2\text{O} + \text{Light Energy} \xrightarrow{\text{Chlorophyll}} \text{C}_6\text{H}_{12}\text{O}_6 + 6\text{O}_2
  • Cellular Respiration Equation: C6H12O6+6O2→6CO2+6H2O+36–38 ATP\text{C}_6\text{H}_{12}\text{O}_6 + 6\text{O}_2 \rightarrow 6\text{CO}_2 + 6\text{H}_2\text{O} + 36\text{--}38\text{ ATP} Respiration occurs in three stages: Glycolysis (cytoplasm, anaerobic, net 2 ATP), Krebs Cycle (mitochondrial matrix, 2 ATP), and Oxidative Phosphorylation / Electron Transport Chain (inner mitochondrial membrane, ~32–34 ATP).

Genetics & Inheritance

Gregor Mendel's Laws of Inheritance:

  1. Monohybrid Cross (Aa×AaAa \times Aa): Produces a 3:1 phenotypic ratio (Dominant : Recessive) and a 1:2:1 genotypic ratio (1AA:2Aa:1aa1 AA : 2 Aa : 1 aa).
  2. Dihybrid Cross (AaBb×AaBbAaBb \times AaBb): Produces a 9:3:3:1 phenotypic ratio.
  3. Central Dogma: DNA →Transcription\xrightarrow{\text{Transcription}} RNA →Translation\xrightarrow{\text{Translation}} Protein. DNA uses bases A, T, C, G; RNA replaces Thymine with Uracil (U).

2. Chemical Sciences

Atomic Structure & Periodic Trends

  • Subatomic Particles: Protons (p+p^+, +1+1 charge, mass ≈1 amu\approx 1\text{ amu}), Neutrons (n0n^0, neutral, mass ≈1 amu\approx 1\text{ amu}), Electrons (e−e^-, −1-1 charge, negligible mass).
  • Atomic Number (ZZ): Number of protons (defines the element). Mass Number (AA): Protons ++ Neutrons.
Periodic Table Trends:
  Increase Electronegativity & Ionization Energy  --->
  +--------------------------------------------------+
  |                                                  | ^
  |                                                  | |
  |                                                  | |
  +--------------------------------------------------+
  Increase Atomic Radius <--- | Downward Increase v
  • Electronegativity: The ability of an atom to attract shared electrons in a bond (Fluorine is the most electronegative element).
  • Ionization Energy: Energy required to remove an electron from a gaseous atom.
  • Atomic Radius: Distance from nucleus to valence shell; decreases across a period (left to right) and increases down a group.

Bonding & pH Scale

  • Ionic Bonding: Transfer of electrons from a metal (cation) to a nonmetal (anion), e.g., NaCl\text{NaCl}.
  • Covalent Bonding: Sharing of electron pairs between nonmetal atoms, e.g., H2O,CO2\text{H}_2\text{O}, \text{CO}_2.
  • pH Scale: Logarithmic scale measuring hydrogen ion concentration: pH=−log⁡[H+]\text{pH} = -\log[\text{H}^+].
    • pH<7\text{pH} < 7: Acidic (higher [H+][\text{H}^+])
    • pH=7\text{pH} = 7: Neutral (pure water at 25∘C25^\circ\text{C})
    • pH>7\text{pH} > 7: Basic / Alkaline
    • Logarithmic Rule: A drop from pH 6 to pH 4 represents a 100-fold (10210^2) increase in acidity ([H+][\text{H}^+]).

3. Physics & Mechanics

Classical Mechanics & Newton's Laws

  1. First Law (Inertia): An object remains at rest or in uniform motion unless acted upon by a net external force.
  2. Second Law (F=maF = ma): Force equals mass times acceleration (1 N=1 kg⋅m/s21\text{ N} = 1\text{ kg}\cdot\text{m/s}^2).
  3. Third Law (Action-Reaction): For every action, there is an equal and opposite reaction.

Work, Energy & Electricity

  • Work: W=F⋅d⋅cos⁡θW = F \cdot d \cdot \cos\theta (measured in Joules, 1 J=1 N⋅m1\text{ J} = 1\text{ N}\cdot\text{m}).
  • Kinetic Energy: KE=12mv2KE = \frac{1}{2} m v^2 | Potential Energy: PE=mghPE = m g h.
  • Law of Conservation of Energy: Total mechanical energy (KE+PEKE + PE) remains constant in an isolated system without friction.
  • Ohm's Law: V=IRV = I R, where VV is Voltage (Volts), II is Current (Amperes), and RR is Resistance (Ohms Ω\Omega).

4. Earth & Atmospheric Science

Earth Structure & Plate Tectonics

Earth is divided into Crust, Mantle, Outer Core (liquid iron-nickel driving the magnetic field), and Inner Core (solid iron-nickel).

  • Convergent Boundaries: Plates collide (subduction zones form deep trenches, volcanic arcs, and mountain ranges like the Himalayas).
  • Divergent Boundaries: Plates separate (mid-ocean ridges, rift valleys).
  • Transform Boundaries: Plates slide past each other horizontally (cause shallow earthquakes along fault lines like the Marikina Valley Fault System).

Atmospheric Layers & Weather Events

  • Troposphere: Lowest layer containing 75% of atmospheric mass; all weather phenomena occur here.
  • Stratosphere: Contains the Ozone Layer (O3\text{O}_3), which absorbs harmful ultraviolet (UV-B and UV-C) solar radiation.
  • El Niño vs. La Niña: El Niño is the anomalous warming of sea surface temperatures in the central/eastern tropical Pacific, causing prolonged droughts in the Philippines. La Niña involves anomalous cooling, bringing heavy rainfall and flooding.
Test Your Knowledge

During cellular respiration, in which specific location of a eukaryotic cell does oxidative phosphorylation via the electron transport chain take place to yield the majority of ATP molecules?

A

Cytoplasm

B

Mitochondrial Matrix

C

Ribosomal Subunit

D

Inner Mitochondrial Membrane

Test Your Knowledge

If a solution's pH changes from 8.0 to 5.0, by what factor has the hydrogen ion concentration [H+] increased?

A

1,000 times

B

300 times

C

30 times

D

3 times

Test Your Knowledge

According to Newton's Second Law of Motion, what net force is required to accelerate a 1,200 kg vehicle at a rate of 3.0 m/s²?

A

400 N

B

3,600 N

C

4,000 N

D

10,800 N

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