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Sample EUS Practice Questions

Try these sample questions to review concepts for the EUS exam. Each question includes a detailed explanation. Start the interactive quiz above for the full 38+ question experience with AI tutoring.

1A medicinal chemist compares lidocaine with procaine. Which structural distinction correctly classifies their principal connecting groups?

A.Both are esters

B.Lidocaine is an amide; procaine is an ester

C.Lidocaine is an ester; procaine is an amide

D.Both are carbamates

Explanation: Lidocaine is an amide local anesthetic, whereas procaine is an ester local anesthetic. This distinction helps organize chemical stability and metabolism without implying that every member has identical kinetics.

2Enalapril is hydrolyzed after absorption to enalaprilat. What is the principal medicinal-chemistry rationale for administering the ester prodrug orally?

A.To make the parent ester the more potent ACE inhibitor

B.To eliminate the need for bioactivation

C.To prevent ester hydrolysis after absorption

D.To improve oral delivery of the poorly absorbed active diacid

Explanation: Enalapril masks a carboxyl group as an ester and is converted to active enalaprilat. The prodrug improves oral delivery compared with administering poorly absorbed enalaprilat orally.

3A receptor binds one enantiomer of a chiral medicine more strongly than the other. Which inference is most defensible?

A.The receptor's chiral binding environment can distinguish the enantiomers

B.Both enantiomers must have identical biological effects

C.The weaker-binding enantiomer must be chemically absent from a racemate

D.R configuration always means greater clinical potency

Explanation: Biological targets are chiral and can interact differently with enantiomers. Binding, metabolism, and safety must be evaluated rather than inferred from the R or S label alone.

4An aqueous aliquot contains 10 mmol total of a monoprotic weak acid with pKa 5.0. Use pH = pKa + log10(ionized/unionized). At pH 6.0, approximately how much remains unionized?

A.0.10 mmol

B.5.00 mmol

C.0.91 mmol

D.9.09 mmol

Explanation: The ionized-to-unionized ratio is 10:1, giving eleven total parts. The unionized amount is 10/11 = approximately 0.91 mmol under the stated equilibrium model.

5An ester-containing drug degrades faster in aqueous alkaline conditions. Which reaction most directly explains cleavage into a carboxylate and an alcohol?

A.Aromatic nitration

B.Ester hydrolysis

C.Disulfide reduction

D.Peptide racemization

Explanation: Ester hydrolysis cleaves the ester bond to the corresponding acid or carboxylate and alcohol. Formulation pH and water exposure can therefore affect stability.

6A beta-lactam antibiotic loses antibacterial activity after enzymatic opening of its beta-lactam ring. Which relationship best explains the change?

A.Ring opening preserves the same acylating pharmacophore

B.Hydrolysis increases affinity for a ribosomal target

C.Side-chain polarity alone preserves activity after ring opening

D.The intact strained ring is important for reaction with bacterial penicillin-binding proteins

Explanation: The intact beta-lactam ring is central to the antibiotic's reaction with penicillin-binding proteins involved in cell-wall synthesis. Ring hydrolysis can destroy that functional pharmacophore and cause loss of activity.

7A dried leaf preparation of Senna alexandrina is selected for occasional constipation. Which constituent group is chiefly associated with its stimulant laxative activity?

A.Hydroxyanthracene glycosides, including sennosides

B.Cardenolides

C.Tropane alkaloids

D.Methylxanthines

Explanation: Senna contains hydroxyanthracene derivatives, including sennosides, associated with its stimulant laxative action. It should not be confused with cardiac glycoside, antimuscarinic, or methylxanthine drugs.

8A patient using large amounts of liquorice develops hypertension and hypokalemia. Which herbal constituent is most relevant to investigate?

A.Sennosides

B.Caffeine

C.Glycyrrhizin-related constituents

D.Ephedrine

Explanation: Liquorice constituents related to glycyrrhizin can produce mineralocorticoid-like adverse effects. A medicine and dietary history should therefore include liquorice exposure when this pattern appears.

9A patient adds a high-hyperforin St. John's wort preparation to a medicine regimen. Which pharmacokinetic concern deserves particular review?

A.Enzyme inhibition that consistently raises substrate exposure

B.Enzyme and transporter induction that may reduce exposure to susceptible medicines

C.Reduced renal filtration as the principal interaction

D.Protein-binding displacement as the sole interaction mechanism

Explanation: Hyperforin-containing St. John's wort preparations can induce drug-metabolizing enzymes and transporters. The magnitude of an interaction depends on the preparation and the affected medicine.

10Which plant part constitutes ispaghula husk used as a bulk-forming medicinal substance?

A.Peppermint flowering tops

B.Valerian underground parts

C.Liquorice roots

D.Seed coats of Plantago ovata

Explanation: Ispaghula husk is obtained from the seed coats of Plantago ovata. Its water-binding fiber contributes to bulk-forming effects.

About the EUS Exam

Independent practice for EUS pharmacy knowledge topics. This English-language MCQ study adaptation is not an official translation, Turkish-language rehearsal, electronic interface simulation, or substitute for professional practical training.

Exam sponsor: ÖSYM. The requirements and fees below concern the certification or admission exam, separate from our free practice resources.

Assessment

One on-site electronic MCQ examination in Ankara, not remote testing. No mandatory oral, practical, assignment, or separately assessed case-study component is specified for the entrance examination; specialty training requirements are separate.

Time Limit

110 minutes

Passing Score

45 weighted points for preferences; not guaranteed placement

Exam / Certification Fees

TRY 2,500 standard 2026 fee; late applications cost 50% more

Exam sponsor website

Fees, eligibility, and exam policies can change. Confirm them with the exam sponsor before applying or paying.

Official sources

ÖSYM 2026 EUS guide, including electronic delivery and Table 1 · Source checked 2026-10-21
ÖSYM published EUS and pharmacy STS Turkish question materials · Source checked 2026-10-21Used to confirm the published assessment language, not to infer current item counts.

Our practice resources: topics covered

We aim to reflect publicly available exam outlines and topic information in our study resources. Coverage, format, and difficulty may differ from the actual exam, and we cannot guarantee that every detail is accurate or current. Confirm exam requirements, fees, and policies with the official exam sponsor.

18 of 38 study questions

Three major pharmaceutical fields

Six each in pharmaceutical chemistry, pharmacognosy/botany, and technology.

12 of 38 study questions

Analysis, pharmacology, clinical pharmacy, and toxicology

Three in each field.

8 of 38 study questions

Supporting biomedical and professional fields

Two each in physiology/pathology and biochemistry; one each in microbiology/immunology, medical biology, law/ethics, and public health. Small-bank rounding differs from exact official proportions.

Preparing for the EUS Exam

What You Need to Know

Passing score: 45 weighted points for preferences; not guaranteed placement
Assessment: One on-site electronic MCQ examination in Ankara, not remote testing. No mandatory oral, practical, assignment, or separately assessed case-study component is specified for the entrance examination; specialty training requirements are separate.
Time limit: 110 minutes
Exam / certification fees: TRY 2,500 standard 2026 fee; late applications cost 50% more Official sources

Using Our Practice Resources

Work through all 38 available questions
Review every answer and explanation
Track weak areas and revisit them
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EUS: Suggested Study Strategy

1Use the 2026 guide's thirteen-field table and current registration instructions.

2Work calculations with units and review drug-safety assumptions.

3Study Turkish professional terminology and the current Turkish legal framework separately from general ethics questions.

Frequently Asked Questions

Is EUS a take-at-home examination?

No. The 2026 guide specifies electronic delivery at the ÖSYM examination centre in Ankara.

Does a score of 45 guarantee training admission?

No. It is the preference threshold; ranking, quotas, English-language qualification, and other conditions remain relevant.