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100+ Free MRCPI GM Part II Written Practice Questions

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2026 Statistics

Key Facts: MRCPI GM Part II Written Exam

150 SBA questions

Two papers of 75 single-best-answer questions each on the Part II Written exam

RCPI MRCPI General Medicine Part II Written

5 hours

Total exam time, 2.5 hours per paper with a 90-minute break under remote invigilation

RCPI MRCPI General Medicine Part II Written

€750

Exam fee for the 2026 MRCPI Part II Written diets for all candidates

RCPI Examinations Schedule 2026

No negative marking

Each correct answer scores one mark and unanswered questions are not penalised

RCPI MRCPI General Medicine Regulations

No basic science

Part II contains no basic science questions, unlike Part I

RCPI MRCPI General Medicine Part II Written

5 options

Each official question presents a stem with five options and one single best answer

RCPI MRCPI General Medicine Regulations

6 years

Part I must have been passed within the previous six years to apply for Part II

RCPI MRCPI General Medicine Part II Written

100

Free original SBA practice questions provided here

OpenExamPrep

The MRCPI General Medicine Part II Written exam is RCPI's second-stage written test of internal medicine, sat after Part I and before the Part II Clinical. It is two papers of 75 Single Best Answer questions each (150 total), delivered online via remote invigilation, with 2.5 hours per paper and a 90-minute break, for five hours in total. The 2026 fee is €750 and there is no negative marking. Questions are blueprinted by specialty (cardiology, respiratory, gastroenterology and hepatology, nephrology, endocrinology each carry 10%; neurology and related disciplines, rheumatology, and immunology and haematology each 10%; infectious diseases, oncology and palliative care, dermatology, and therapeutics each 5%) and emphasise data interpretation and management. This 100-question bank provides original SBA practice mapped to that blueprint.

Sample MRCPI GM Part II Written Practice Questions

Try these sample questions to test your MRCPI GM Part II Written exam readiness. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.

1A 68-year-old man presents with 40 minutes of central crushing chest pain. ECG shows 2 mm ST elevation in leads II, III and aVF. Which coronary artery is most likely occluded?
A.Left anterior descending artery
B.Right coronary artery
C.Left circumflex artery
D.Left main stem
Explanation: ST elevation in the inferior leads II, III and aVF indicates an inferior STEMI, which in most people is supplied by the right coronary artery. Recognising the territory guides expectations such as bradyarrhythmias and possible right ventricular involvement.
2A 72-year-old woman with an inferior STEMI becomes hypotensive after sublingual nitrate. Her chest is clear and JVP is elevated. Which additional ECG lead is most useful to confirm the likely cause?
A.V4R
B.V7
C.aVR
D.Lead I with reversed limbs
Explanation: Hypotension after nitrates in an inferior STEMI with clear lungs and raised JVP suggests right ventricular infarction, which is preload-dependent. ST elevation in the right-sided lead V4R confirms RV involvement, and management is cautious fluid loading and avoiding nitrates.
3A 60-year-old man has progressive exertional dyspnoea. Echocardiography shows left ventricular ejection fraction of 30%. Which class of drug has the clearest mortality benefit and should be started first alongside a beta-blocker?
A.Loop diuretic
B.ACE inhibitor
C.Digoxin
D.Calcium channel blocker
Explanation: In heart failure with reduced ejection fraction, ACE inhibitors and beta-blockers are foundational disease-modifying therapy with proven mortality benefit. Loop diuretics relieve congestion symptoms but do not improve survival.
4A 75-year-old man with heart failure and an ejection fraction of 28% remains symptomatic on maximal ACE inhibitor and beta-blocker. He is in sinus rhythm at 82 bpm with potassium 4.4 mmol/L. What is the most appropriate next addition?
A.Ivabradine
B.A mineralocorticoid receptor antagonist
C.Amlodipine
D.Digoxin
Explanation: Adding a mineralocorticoid receptor antagonist such as spironolactone or eplerenone reduces mortality in symptomatic HFrEF already on an ACE inhibitor and beta-blocker, provided potassium and renal function permit. Ivabradine is reserved for heart rates of 75 bpm or above where it cannot be lowered further, not this patient.
5A 70-year-old woman has palpitations. ECG shows an irregularly irregular rhythm with no P waves at 130 bpm. She is haemodynamically stable with onset more than 48 hours ago. What is the most appropriate immediate priority?
A.Immediate DC cardioversion
B.Rate control and anticoagulation assessment
C.Intravenous adenosine
D.Permanent pacemaker insertion
Explanation: This is atrial fibrillation. In a stable patient with onset over 48 hours, the priority is rate control and assessment of stroke risk for anticoagulation, because immediate cardioversion without anticoagulation or transoesophageal echocardiography risks thromboembolism.
6A 55-year-old man with non-valvular atrial fibrillation has hypertension and diabetes but no prior stroke. Using the CHA2DS2-VASc score, what is the most appropriate management of his thromboembolic risk?
A.No antithrombotic therapy
B.Aspirin alone
C.Oral anticoagulation
D.Clopidogrel alone
Explanation: His CHA2DS2-VASc score is 2 (hypertension 1, diabetes 1), which warrants oral anticoagulation, usually a direct oral anticoagulant. Aspirin is no longer recommended for stroke prevention in atrial fibrillation.
7A 38-year-old man presents with pleuritic chest pain that is relieved by sitting forward. ECG shows widespread saddle-shaped ST elevation and PR depression. What is the most likely diagnosis?
A.Acute pericarditis
B.Anterior STEMI
C.Pulmonary embolism
D.Aortic dissection
Explanation: Pleuritic pain relieved by leaning forward with widespread concave ST elevation and PR depression is characteristic of acute pericarditis. The changes are not confined to a single coronary territory, distinguishing it from STEMI.
8A 64-year-old man has exertional syncope and an ejection systolic murmur radiating to the carotids with a slow-rising pulse. Echocardiography shows a valve area of 0.8 cm2 and a mean gradient of 50 mmHg. What is the definitive treatment?
A.Lifelong beta-blockade
B.Balloon valvuloplasty only
C.Aortic valve replacement
D.Vasodilator therapy
Explanation: This is severe symptomatic aortic stenosis (valve area under 1 cm2, mean gradient over 40 mmHg) presenting with exertional syncope. Symptomatic severe aortic stenosis is an indication for valve replacement, surgical or transcatheter; medical therapy does not alter the prognosis.
9A 28-year-old intravenous drug user has fever, a new pansystolic murmur and multiple cavitating lung lesions on chest imaging. Which valve is most likely affected?
A.Aortic valve
B.Mitral valve
C.Tricuspid valve
D.Pulmonary valve
Explanation: Right-sided endocarditis from intravenous drug use most commonly affects the tricuspid valve and embolises to the lungs, producing septic pulmonary emboli that appear as multiple cavitating lesions. Staphylococcus aureus is the usual organism.
10A 45-year-old man is found to have a blood pressure of 170/105 mmHg on repeated readings. Investigations show potassium 3.0 mmol/L, an elevated aldosterone-to-renin ratio and a left adrenal adenoma. What is the most likely diagnosis?
A.Phaeochromocytoma
B.Primary hyperaldosteronism
C.Renal artery stenosis
D.Cushing syndrome
Explanation: Hypertension with hypokalaemia and a raised aldosterone-to-renin ratio plus an adrenal adenoma indicates primary hyperaldosteronism (Conn syndrome). Confirmation and adrenal vein sampling guide adrenalectomy or a mineralocorticoid receptor antagonist.

About the MRCPI GM Part II Written Exam

The MRCPI General Medicine Part II Written examination is the second of three components of the MRCPI in General Medicine, the postgraduate membership qualification of the Royal College of Physicians of Ireland for internal medicine. It is taken after MRCPI General Medicine Part I and assesses the diagnosis and management of patients across the breadth of hospital general (internal) medicine. The exam consists of two papers, each with 75 Single Best Answer questions, delivered online via remote invigilation worldwide. Unlike Part I, there are no basic science questions; vignettes are longer and more clinical, and many questions require interpretation of investigations, imaging and data. Questions are blueprinted across cardiology, respiratory medicine, gastroenterology and hepatology, nephrology, endocrinology, neurology and related disciplines, rheumatology, immunology and haematology, infectious diseases, oncology and palliative care, dermatology, and therapeutics and toxicology.

Assessment

Two papers, each with 75 Single Best Answer (SBA) questions, for 150 questions in total. Each question is a clinical vignette with five options and one best answer; all questions are equally weighted with one mark each and no negative marking.

Time Limit

Five hours in total: each paper is 2.5 hours, with a 90-minute break between the two papers under remote invigilation.

Passing Score

Criterion-referenced. A pass standard is set for each diet by standard-setting so the standard stays consistent between examinations; there is no fixed percentage published and no negative marking.

Exam Fee

€750 for the 2026 diets, for both Irish and overseas candidates, paid by credit or debit card at application. (Royal College of Physicians of Ireland (RCPI))

MRCPI GM Part II Written Exam Content Outline

10%

Cardiology

Acute coronary syndromes, heart failure, arrhythmias, valvular and pericardial disease, hypertension, endocarditis and ECG, echocardiography and haemodynamic interpretation.

10%

Respiratory Medicine

Asthma, COPD, pneumonia, interstitial lung disease, pulmonary embolism, pleural effusion and interpretation of spirometry, arterial blood gases and chest imaging.

10%

Gastroenterology & Hepatology

Inflammatory bowel disease, upper and lower GI bleeding, chronic liver disease and decompensation, pancreatitis, coeliac disease and liver-function and endoscopic interpretation.

10%

Nephrology

Acute kidney injury, chronic kidney disease, glomerulonephritis, electrolyte and acid-base disorders, hypertension and interpretation of renal and urinary investigations.

10%

Endocrinology & Metabolic Medicine

Type 1 and 2 diabetes and emergencies, thyroid, adrenal, pituitary, parathyroid and calcium disorders, and interpretation of dynamic endocrine testing.

10%

Neurology, Ophthalmology & Psychiatry

Stroke and TIA, seizures and status epilepticus, headache, neuromuscular and movement disorders, plus common ophthalmic and psychiatric presentations seen by physicians.

10%

Rheumatology

Rheumatoid and seronegative arthritis, SLE and connective tissue disease, vasculitis, crystal arthropathies and interpretation of autoantibody and inflammatory marker patterns.

10%

Immunology & Haematology

Anaemias, haematological malignancies, coagulation and thrombosis, transfusion medicine and immunodeficiency, with blood film, coagulation and electrophoresis interpretation.

5%

Infectious Diseases & Genitourinary Medicine

Sepsis and antimicrobial selection, HIV, tuberculosis, hospital and travel-related infection and sexually transmitted infections in the medical patient.

5%

Oncology & Palliative Care

Oncological emergencies, principles of systemic anti-cancer therapy and immunotherapy toxicity, paraneoplastic syndromes and symptom control in palliative care.

5%

Dermatology

Eczema, psoriasis and skin infections, cutaneous signs of systemic disease, drug eruptions and recognition of dermatological emergencies such as toxic epidermal necrolysis.

5%

Therapeutics & Toxicology

Clinical pharmacology, prescribing in renal and hepatic impairment and pregnancy, drug interactions and adverse effects, and the assessment and management of poisoning.

How to Pass the MRCPI GM Part II Written Exam

What You Need to Know

  • Passing score: Criterion-referenced. A pass standard is set for each diet by standard-setting so the standard stays consistent between examinations; there is no fixed percentage published and no negative marking.
  • Assessment: Two papers, each with 75 Single Best Answer (SBA) questions, for 150 questions in total. Each question is a clinical vignette with five options and one best answer; all questions are equally weighted with one mark each and no negative marking.
  • Time limit: Five hours in total: each paper is 2.5 hours, with a 90-minute break between the two papers under remote invigilation.
  • Exam fee: €750 for the 2026 diets, for both Irish and overseas candidates, paid by credit or debit card at application.

Keys to Passing

  • Complete 500+ practice questions
  • Score 80%+ consistently before scheduling
  • Focus on highest-weighted sections
  • Use our AI tutor for tough concepts

MRCPI GM Part II Written Study Tips from Top Performers

1Use the RCPI General Medicine Regulations blueprint to spread your revision across the specialty weightings, giving roughly equal time to cardiology, respiratory, gastroenterology, nephrology, endocrinology, neurology, rheumatology and haematology.
2Practise interpreting investigations under time pressure: ECGs, chest X-rays, blood gases, liver and renal panels, blood films and autoantibody patterns appear throughout Part II.
3Read each vignette for the single best answer, not merely a correct one; identify the most likely diagnosis or the most appropriate next step rather than any plausible option.
4Because there is no negative marking, never leave a question blank; eliminate options and make your best choice on every item.
5Drill management and 'next step' questions, since Part II emphasises diagnosis and management over recall of isolated facts.
6Work through large numbers of clinical SBAs to build speed; with 150 questions over five hours you have roughly two minutes per question, so pace and stamina matter.

Frequently Asked Questions

How many questions are on the MRCPI General Medicine Part II Written exam?

There are 150 Single Best Answer questions, split across two papers of 75 questions each. Each question is equally weighted with one mark and there is no negative marking, so candidates should attempt every question.

How long is the MRCPI Part II Written exam?

Each paper lasts 2.5 hours, giving five hours of exam time in total. Under remote invigilation there is currently a 90-minute break between the two papers.

Is there a fixed pass mark for MRCPI Part II Written?

No. The pass standard is set for each diet using standard-setting so the required standard is consistent between examinations. There is no published fixed percentage and no negative marking.

Does Part II include basic science questions?

No. Unlike Part I, the Part II Written exam contains no basic science questions. It focuses on the diagnosis and management of patients, with longer clinical vignettes and frequent interpretation of investigations and data.

What are the entry requirements for the Part II Written exam?

You must have passed MRCPI General Medicine Part I or MRCPI Paediatrics Part I within the last six years, or hold an exempting qualification. If that six-year period has expired you must re-sit Part I. FRACP holders may apply for exemption.

Where and how is the exam delivered?

The Part II Written exam is computer-based and delivered worldwide via remote invigilation, so candidates can sit it anywhere with a reliable internet connection. The 2026 fee is €750.