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100+ Free PSI Equivalence Exam Practice Questions
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Adrenaline (epinephrine) 1:1,000 injection is to be used. What mass of adrenaline is contained in 0.5 mL of a 1:1,000 solution?
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B
C
D
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Sample PSI Equivalence Exam Practice Questions
Try these sample questions to test your PSI Equivalence Exam exam readiness. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.
1A child weighing 15 kg is prescribed amoxicillin oral suspension at a dose of 40 mg/kg/day in three divided doses. The available suspension is 250 mg/5 mL. What volume should be given for each individual dose?
A.4 mL
B.2 mL
C.6 mL
D.8 mL
Explanation: Total daily dose = 40 mg/kg x 15 kg = 600 mg/day. Divided into three doses = 200 mg per dose. At 250 mg/5 mL the concentration is 50 mg/mL, so 200 mg / 50 mg/mL = 4 mL per dose. Weight-based paediatric calculations are a core skill assessed in Part A of the PSI MCQ.
2A patient requires a heparin infusion at 1,000 units/hour. The infusion bag contains 25,000 units of heparin in 500 mL of sodium chloride 0.9%. At what rate in mL/hour should the infusion pump be set?
A.10 mL/hour
B.20 mL/hour
C.25 mL/hour
D.50 mL/hour
Explanation: The concentration is 25,000 units / 500 mL = 50 units/mL. To deliver 1,000 units/hour, divide 1,000 by 50 = 20 mL/hour. Infusion-rate calculations are routinely assessed in the calculations component of the PSI equivalence MCQ.
3How many grams of sodium chloride are required to prepare 250 mL of a 0.9% w/v sodium chloride solution?
A.0.9 g
B.9 g
C.2.25 g
D.22.5 g
Explanation: A 0.9% w/v solution contains 0.9 g per 100 mL. For 250 mL: 0.9 g x (250/100) = 2.25 g. Understanding the w/v percentage convention (grams per 100 mL) is fundamental to dispensing calculations.
4A 1 in 5,000 solution of potassium permanganate is requested. How many milligrams of potassium permanganate are contained in 200 mL of this solution?
A.4 mg
B.100 mg
C.400 mg
D.40 mg
Explanation: A 1 in 5,000 ratio strength means 1 g in 5,000 mL, i.e. 0.2 mg/mL. For 200 mL: 0.2 mg/mL x 200 mL = 40 mg. Ratio strength expressions are a standard calculation type in pharmacy practice.
5A patient is to receive paracetamol 15 mg/kg every 6 hours and weighs 70 kg. What is the maximum number of milligrams the patient should receive in a 24-hour period from this regimen, and does it stay within the standard 4 g daily limit?
A.4,200 mg, exceeds limit
B.3,150 mg, within limit
C.4,200 mg, within limit
D.6,300 mg, exceeds limit
Explanation: Single dose = 15 mg/kg x 70 kg = 1,050 mg. Every 6 hours means 4 doses in 24 hours: 1,050 x 4 = 4,200 mg, which exceeds the standard maximum of 4 g (4,000 mg) per 24 hours. The pharmacist should flag this and consider capping individual doses at 1 g.
6An adult is prescribed gentamicin 5 mg/kg once daily and weighs 64 kg. The injection is available as 80 mg in 2 mL. What volume should be drawn up for one dose?
A.6 mL
B.8 mL
C.10 mL
D.16 mL
Explanation: Dose = 5 mg/kg x 64 kg = 320 mg. The concentration is 80 mg / 2 mL = 40 mg/mL, so 320 mg / 40 mg/mL = 8 mL. Accurate volume calculation from injection strengths is critical for safe parenteral dosing.
7A prescription requires 30 g of a 2% w/w hydrocortisone ointment, but only 1% and 5% hydrocortisone ointments are available. Using the alligation method, in what ratio (1% : 5%) should they be mixed?
A.1 : 3
B.1 : 1
C.3 : 1
D.2 : 3
Explanation: Using alligation: the 1% differs from the target by |5 - 2| = 3 parts, and the 5% differs by |1 - 2| = 1 part. So mix 3 parts of 1% with 1 part of 5% (3:1). This yields the 2% target strength. Alligation is a recognised technique for adjusting concentrations.
8A patient on warfarin needs an INR-adjusted weekly dose of 35 mg. Tablets available are 1 mg, 3 mg and 5 mg. Which once-daily regimen most simply delivers exactly 35 mg per week using the fewest tablet strengths?
A.3 mg daily plus alternate 1 mg
B.5 mg on five days, 5 mg on the other two
C.1 mg daily
D.5 mg daily
Explanation: 5 mg daily x 7 days = 35 mg per week exactly, using a single tablet strength. Warfarin is dosed to a weekly total guided by INR, and simplifying the regimen reduces dosing errors and improves adherence.
9A morphine sulfate oral solution is 10 mg/5 mL. A palliative patient is prescribed 15 mg four times daily. How many millilitres are required to supply a 7-day course?
A.210 mL
B.150 mL
C.300 mL
D.420 mL
Explanation: Each dose of 15 mg = 7.5 mL (since 10 mg = 5 mL). Four doses/day = 30 mL/day. Over 7 days = 210 mL. Quantity calculations for controlled drugs must be exact, as the total supplied must match the prescription.
10A solution contains 5% w/v glucose. How many calories (approximately) are provided by 1 litre, given that glucose provides about 4 kcal per gram?
A.50 kcal
B.200 kcal
C.100 kcal
D.400 kcal
Explanation: 5% w/v glucose = 5 g per 100 mL = 50 g per litre. At 4 kcal/g, 50 g x 4 = 200 kcal per litre. Converting between percentage strength, mass and energy content is relevant to parenteral nutrition calculations.
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