11.4 Osteoarthritis, Low Back Pain, Polymyalgia Rheumatica, Fibromyalgia & Soft Tissue Disorders
Key Takeaways
NICE NG226 diagnoses osteoarthritis clinically, without imaging, in people aged 45 or over with activity-related joint pain and no morning stiffness or stiffness lasting 30 minutes or less.
First-line osteoarthritis care is therapeutic exercise and weight loss; topical NSAIDs are the first-line drug for knee osteoarthritis, and strong opioids should not be offered.
For low back pain without red flags, NICE NG59 advises against routine imaging and against paracetamol alone, recommending exercise, self-management and an NSAID if needed.
Polymyalgia rheumatica causes bilateral shoulder and hip girdle pain and stiffness in people over 50 with raised inflammatory markers and responds rapidly to prednisolone 12.5–25 mg daily.
The Ottawa ankle rules require an X-ray only if there is malleolar bone tenderness at the posterior edge or tip, or inability to bear weight for 4 steps.
Osteoarthritis, Low Back Pain, Polymyalgia Rheumatica, Fibromyalgia & Soft Tissue Disorders
Osteoarthritis (OA, NICE NG226)
- Clinical diagnosis without imaging if the person is 45 or over, has activity-related joint pain, and has no morning stiffness or stiffness lasting 30 minutes or less.
- Signs: crepitus, bony swelling, reduced range of movement; in the hands, Heberden's nodes (DIP joints) and Bouchard's nodes (PIP joints), and base-of-thumb involvement.
- X-ray features (if done): Loss of joint space, Osteophytes, Subchondral sclerosis, Subchondral cysts.
Management
- Therapeutic exercise (strengthening and aerobic) and weight loss if overweight; information and self-management support.
- Topical NSAIDs for knee OA (consider for other joints).
- Oral NSAIDs at the lowest effective dose for the shortest time, with a PPI where needed.
- Do not routinely offer paracetamol or weak opioids (except infrequent short-term use when other options are unsuitable), and do not offer strong opioids, glucosamine, hyaluronan injections or arthroscopic washout.
- Intra-articular corticosteroid for short-term relief of a flare.
- Joint replacement referral when symptoms substantially affect quality of life despite non-surgical treatment (no specific age, BMI or imaging thresholds).
Low Back Pain & Sciatica (NICE NG59)
Red Flags
| Possible Cause | Features |
|---|---|
| Cauda equina syndrome | Bilateral sciatica, saddle anaesthesia, bladder or bowel dysfunction, sexual dysfunction |
| Malignancy | Age over 50, previous cancer, weight loss, constant or night pain, thoracic pain |
| Infection | Fever, IV drug use, immunosuppression, recent spinal procedure |
| Fracture | Significant trauma, osteoporosis, long-term corticosteroids |
| Inflammatory (axial spondyloarthritis) | Under 40, gradual onset, morning stiffness over 30 minutes, improves with exercise, night pain in the second half of the night |
Non-Specific Low Back Pain
- Do not routinely image in non-specialist settings.
- Use a risk tool (such as STarT Back) to guide intensity of care.
- Encourage activity, self-management and group exercise programmes; manual therapy and psychological therapy only as part of a package with exercise.
- Oral NSAIDs (lowest dose, shortest time) if needed; weak opioids (with or without paracetamol) only for acute pain when NSAIDs are unsuitable.
- Do not offer paracetamol alone, SSRIs, SNRIs, tricyclics or gabapentinoids for low back pain.
Sciatica
Leg pain in a dermatomal distribution (often L5 or S1) from nerve root compression, usually a disc prolapse. Most cases settle over 6–12 weeks. NICE advises against gabapentinoids, other antiepileptics, oral corticosteroids and benzodiazepines for sciatica, and against opioids for chronic sciatica. Consider epidural injection for acute severe sciatica and spinal decompression when non-surgical treatment has failed and imaging matches the symptoms. Cauda equina features need emergency MRI (section 11.3).
Polymyalgia Rheumatica (PMR)
- Features: age over 50, bilateral shoulder (and often hip) girdle pain and stiffness, morning stiffness over 45 minutes, fatigue and low-grade fever, with raised ESR or CRP. Muscle strength and CK are normal.
- Before steroids: exclude mimics (rheumatoid arthritis, myeloma, hypothyroidism, infection, malignancy, statin myopathy) with bloods including protein electrophoresis, TFTs, CK and bone profile.
- Treatment: prednisolone 12.5–25 mg daily, expecting a dramatic response within days (if not, reconsider the diagnosis), then a slow taper over 1–2 years with bone protection and monitoring for steroid side effects.
- Giant cell arteritis overlaps with PMR: ask about new headache, scalp tenderness, jaw claudication and visual symptoms at every review; GCA needs higher-dose steroids immediately (section 7.2).
Fibromyalgia & Chronic Primary Pain (NICE NG193)
Chronic widespread pain for more than 3 months with fatigue, unrefreshing sleep and cognitive difficulty, without inflammation. Investigations are normal. Management: explanation, exercise programmes, psychological therapy (CBT, acceptance and commitment therapy) and acupuncture; an antidepressant (for example amitriptyline or duloxetine) may be considered. NICE advises not starting opioids, gabapentinoids, NSAIDs, paracetamol or benzodiazepines for chronic primary pain.
Common Soft Tissue Disorders
| Condition | Key Features | Management |
|---|---|---|
| Frozen shoulder (adhesive capsulitis) | Painful then stiff shoulder with loss of external rotation; diabetes | Analgesia, physiotherapy, intra-articular steroid; resolves over 1–3 years |
| Rotator cuff tendinopathy / subacromial pain | Painful arc (about 60–120 degrees) of abduction | Physiotherapy, subacromial steroid injection |
| Lateral epicondylitis (tennis elbow) | Pain at the lateral epicondyle, worse on resisted wrist extension | Activity modification, physiotherapy; most resolve |
| Carpal tunnel syndrome | Numbness and tingling in the thumb, index and middle fingers, worse at night; Tinel's and Phalen's tests; thenar wasting if severe | Night wrist splint, steroid injection, surgical decompression; nerve conduction studies if uncertain; associations include pregnancy, hypothyroidism, diabetes, RA, acromegaly |
| De Quervain's tenosynovitis | Pain over the radial styloid; positive Finkelstein's test | Splint, steroid injection |
| Trigger finger / Dupuytren's contracture | Catching finger; palmar fascia nodules and flexion contracture | Steroid injection; surgery or needle fasciotomy |
| Achilles tendon rupture | Sudden "kick" sensation, positive Simmonds' (calf squeeze) test; risk with fluoroquinolones | Same-day orthopaedic referral |
Imaging Rules for Ankle and Knee Injuries
- Ottawa ankle rules: X-ray the ankle only if there is pain in the malleolar zone and bone tenderness at the posterior edge or tip of either malleolus, or the patient cannot bear weight for 4 steps both immediately and in the department. X-ray the foot for midfoot pain with tenderness at the base of the fifth metatarsal or the navicular, or inability to bear weight.
- Ottawa knee rules: X-ray for age 55 or over, isolated patellar tenderness, fibular head tenderness, inability to flex to 90 degrees, or inability to bear weight for 4 steps.
Bursitis & Joint Dislocation
- Bursitis: inflamed bursa causing localised swelling and tenderness, for example olecranon (leaning on elbows), prepatellar ("housemaid's knee") and greater trochanteric (lateral hip pain). Treat with rest, ice and NSAIDs. A hot, red, tender bursa with fever may be septic (often Staphylococcus aureus): aspirate for microscopy and culture and treat with flucloxacillin, avoiding steroid injection.
- Shoulder dislocation: most are anterior (arm held abducted and externally rotated, loss of shoulder contour). Check axillary nerve function (sensation over the "regimental badge" area of the lateral upper arm) and distal neurovascular status, take X-rays before and after reduction, and reduce under analgesia and sedation. Posterior dislocations follow seizures or electric shocks.
- Hip dislocation: usually posterior after high-energy trauma (dashboard injury) or in people with hip replacements; the leg is shortened, adducted and internally rotated. It needs urgent reduction to reduce the risk of avascular necrosis and sciatic nerve injury.
A 61-year-old woman has 1 year of right knee pain on walking, with 10 minutes of morning stiffness. There is crepitus and a small effusion. Which statement reflects NICE management?
An X-ray is required to confirm osteoarthritis before treatment
Offer therapeutic exercise and weight advice, with a topical NSAID
Refer for arthroscopic washout of the knee
Start regular paracetamol as the first-line analgesic
A 72-year-old woman has 3 weeks of pain and stiffness in both shoulders and hips, worst for 2 hours each morning. She cannot lift her arms to brush her hair. ESR is 58 mm/h. She has no headache, jaw pain or visual symptoms. Muscle strength is normal. After excluding mimics, what is the most appropriate treatment?
Prednisolone 15 mg daily with bone protection
Prednisolone 60 mg daily as for giant cell arteritis
Naproxen 500 mg twice daily with a PPI, alone
Methotrexate 15 mg weekly as first-line treatment
A 25-year-old man inverts his ankle playing football. He walked 4 steps immediately afterwards and again in the department. There is swelling over the lateral ligament but no tenderness over the posterior edge or tip of either malleolus, the navicular or the base of the fifth metatarsal. What is the most appropriate management?
Ankle X-ray (anteroposterior, lateral and mortise views)
Foot X-ray to exclude a fifth metatarsal base fracture
No X-ray; treat as a sprain with early mobilisation
MRI of the ankle to assess the lateral ligament complex
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