4.3 The Digestive System

Key Takeaways

  • The GI tract runs mouth → esophagus → stomach → small intestine → large intestine; accessory organs are the liver, gallbladder, and pancreas
  • Mechanical digestion physically breaks food apart; chemical digestion uses enzymes to break chemical bonds
  • The liver produces bile, the gallbladder stores it, and bile emulsifies fats into smaller droplets
  • Most nutrient absorption occurs in the small intestine, whose villi and microvilli vastly increase surface area
  • The large intestine mainly reabsorbs water and houses bacteria that produce vitamin K and some B vitamins
Last updated: June 2026

The digestive system converts the food you eat into molecules small enough for your cells to absorb and use. The TEAS tests this system from two angles: the anatomy (which organ does what, in what order) and the biochemistry (which enzyme breaks down which nutrient into which product). A clean mental model separates the system into two groups: the GI (gastrointestinal) tract — the continuous tube from mouth to anus that food actually travels through — and the accessory organs — the liver, gallbladder, and pancreas, which sit outside the tube but secrete substances into it.

Food never passes through the accessory organs; it only receives their secretions.

The GI Tract: An Assembly Line

The alimentary canal is one long tube about 9 meters in an adult. Each segment performs a specialized job before passing material along.

OrganPrimary JobKey Process
MouthBegins mechanical and chemical digestionChewing; salivary amylase breaks down starch
EsophagusTransportPeristalsis pushes food to the stomach
StomachChemical digestion and storageHCl and pepsin break down protein
Small intestineMain digestion and absorptionEnzymes finish digestion; nutrients absorbed
Large intestineWater absorption, waste formationReabsorbs water; forms and stores feces
Rectum / anusEliminationStores and expels waste

Food moves along by peristalsis, the wave-like contraction of smooth muscle in the tube walls. It is involuntary, which is why you can swallow even while upside down.

Mechanical vs. Chemical Digestion

The exam expects you to distinguish two complementary processes that occur simultaneously.

TypeWhat It DoesExamples
MechanicalPhysically breaks food into smaller piecesChewing, stomach churning, segmentation
ChemicalBreaks chemical bonds using enzymesAmylase, pepsin, lipase action

Mechanical digestion increases surface area so chemical digestion can work faster — the two are partners, not rivals. Bile's emulsification of fat is a useful borderline case: it physically breaks large fat globules into tiny droplets (mechanical in effect) but is not an enzyme, so it does not chemically digest the fat itself.

Accessory Organs

OrganSecretionFunction
Salivary glandsSaliva (amylase)Begin starch digestion; lubricate food
LiverBileEmulsifies fats into smaller droplets
GallbladderStores bileReleases bile into the small intestine when fat arrives
PancreasEnzymes + bicarbonateDigests all nutrient types; neutralizes stomach acid

A classic test trap: the liver makes bile, the gallbladder stores it. If a question asks where bile is produced, the answer is the liver, not the gallbladder.

Digestive Enzymes

Enzymes are named for the nutrient they break down, usually ending in -ase. This pattern is your shortcut: amylase acts on starch (amyl-), lipase acts on fats (lip-), and protease acts on protein.

EnzymeSourceActs OnProduces
Salivary amylaseSalivary glandsStarchMaltose
PepsinStomachProteinsPeptides
Pancreatic amylasePancreasStarchMaltose
TrypsinPancreasProteinsPeptides
LipasePancreasFatsFatty acids + glycerol
LactaseSmall intestineLactoseGlucose + galactose
SucraseSmall intestineSucroseGlucose + fructose

Note that pepsin works only in the acidic stomach (created by hydrochloric acid), while the pancreatic enzymes need the alkaline environment that pancreatic bicarbonate creates in the small intestine.

Absorption: The Job of the Small Intestine

The small intestine — divided into the duodenum, jejunum, and ileum — is where the vast majority of nutrients enter the bloodstream. Its inner wall is folded and covered with finger-like villi, and each villus cell is covered with tiny microvilli (the brush border). These two structures multiply the surface area enormously, turning a tube only a few centimeters wide into an absorptive surface the size of a small room.

NutrientPrimary Absorption Site
Carbohydrates (as simple sugars)Small intestine
Proteins (as amino acids)Small intestine
Fats (as fatty acids)Small intestine
WaterLarge intestine (mainly)
Vitamin B12Ileum (last part of small intestine)

The Large Intestine and Nutrients

The large intestine (colon) receives the watery residue the small intestine leaves behind. Its main jobs are to reabsorb water, compact the remaining material into feces, and host beneficial bacteria that synthesize vitamin K and several B vitamins. It performs little nutrient digestion of its own.

Finally, the TEAS expects familiarity with the six macronutrients and micronutrients: carbohydrates (quick energy), proteins (build and repair tissue, made of amino acids), lipids/fats (energy storage and cell membranes), vitamins and minerals (regulate body processes), and water (the solvent for nearly every reaction).

Worked Example: A person drinks a glass of milk but experiences bloating and cramps because they lack the enzyme lactase. Trace what goes wrong. Lactase normally breaks lactose (milk sugar) into glucose and galactose in the small intestine. Without it, undigested lactose passes into the large intestine, where bacteria ferment it, producing gas and drawing in water — the cause of the symptoms. This shows the rule “enzyme-name = substrate + ase” in action: no lactase means no lactose digestion.

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Path of Food Through the GI Tract
Test Your KnowledgeMatching

Match each digestive enzyme to the nutrient it breaks down.

Match each item on the left with the correct item on the right

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Amylase
2
Pepsin
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Lipase
4
Lactase
Test Your Knowledge

Which organ produces bile, and what does bile do?

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B
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D
Test Your Knowledge

Where does the majority of nutrient absorption take place, and what structures make this possible?

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B
C
D
Test Your KnowledgeFill in the Blank

The physical breakdown of food, such as chewing and churning, is called ___ digestion.

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