1.3 Musculoskeletal Interventions

Key Takeaways

  • Maitland mobilization grades I-II treat pain (oscillation in early range); III-IV increase ROM (into resistance); V is a thrust manipulation
  • Mobilization direction follows the concave-convex rule based on which surface is moving
  • Exercise progression: PROM, AAROM, AROM, isometric, isotonic concentric then eccentric, isokinetic
  • PRE protocols: DeLorme progresses light-to-heavy; Oxford progresses heavy-to-light
  • Soft-tissue techniques include effleurage, petrissage, cross-friction massage, myofascial release, and IASTM
  • PNF uses D1/D2 diagonal patterns for the upper and lower extremities
  • Contract-relax and hold-relax use autogenic inhibition (GTO) to gain ROM; CRAC adds reciprocal inhibition
  • Evidence favors active interventions (therapeutic exercise) over passive modalities for most MSK conditions
Last updated: June 2026

Interventions for musculoskeletal conditions run from passive (joint mobilization) to active (therapeutic exercise). The NPTE wants the most appropriate choice for the patient's stage of healing and presentation — and it consistently rewards active, evidence-based care over passive modalities.

Joint Mobilization

Maitland Oscillation Grades

GradeAmplitude / locationPurpose
ISmall, beginning of rangePain relief, joint nutrition
IILarge, within range (not to resistance)Pain relief, early mobility
IIILarge, into resistance at end rangeIncrease ROM
IVSmall, at end range within resistanceIncrease ROM
VHigh-velocity, low-amplitude thrustRestore joint play (manipulation)

Grades I-II modulate pain by stimulating joint mechanoreceptors (gate-control theory). Grades III-IV stretch a restricted capsule to gain ROM. Grade V thrust is a manipulation requiring advanced training and is regulated by state practice acts. A simple rule: pain dominant -> low grades; stiffness dominant -> high grades.

Mobilization Direction (Concave-Convex Rule)

To gain ROM you mobilize in the direction of the restricted glide:

  • Convex moving surface (e.g., humeral head on glenoid): glide opposite the restricted bone motion. To improve shoulder flexion, apply an inferior glide.
  • Concave moving surface (e.g., tibia on femur in open-chain extension): glide in the same direction as the restricted bone motion. To improve knee extension, apply an anterior glide of the tibia.

Mobilization vs. manipulation precautions/contraindications: avoid in the presence of malignancy, acute inflammation/infection, fracture, joint hypermobility/instability, ligamentous rupture, and (for cervical thrust) signs of vertebrobasilar insufficiency or upper-cervical ligament laxity. Always re-screen before high-grade or thrust techniques.

Therapeutic Exercise

Progression Continuum

  1. PROM — therapist moves the joint (acute/post-op).
  2. AAROM — patient initiates, therapist assists.
  3. AROM — patient moves independently against gravity.
  4. Isometrics — force without motion (useful when movement is painful or restricted).
  5. Isotonic concentric — shortening against resistance.
  6. Isotonic eccentric — lengthening against resistance (greatest force; key for tendinopathy).
  7. Isokinetic — resistance accommodates effort at a fixed speed (specialized equipment).

Progressive Resistive Exercise (PRE)

ProtocolDirectionSets (of 10 reps)
DeLormeLight -> heavy50%, 75%, 100% of 10-RM
OxfordHeavy -> light100%, 75%, 50% of 10-RM

DeLorme's ascending load serves as a built-in warm-up; Oxford's descending load front-loads effort before fatigue sets in. General strengthening uses moderate loads (~60-80% 1-RM, 8-12 reps); endurance uses lighter loads and higher reps; power uses higher velocity.

Soft-Tissue Techniques and PNF

TechniqueDescriptionUse
EffleurageLong gliding strokesWarm-up, circulation, relaxation
PetrissageKneading/wringingReduce muscle tension
Cross-friction massageDeep transverse friction across fibersTendinopathy, scar mobilization
Myofascial releaseSustained pressure into fascial restrictionFascial tightness, posture
IASTMInstrument-assisted soft-tissue mobilizationScar, fascial adhesions

PNF Diagonal Patterns

PNF uses spiral, diagonal patterns that mimic function. Upper extremity: D1 flexion = shoulder flexion/adduction/external rotation (hand to opposite shoulder); D2 flexion = shoulder flexion/abduction/external rotation (a 'draw-the-sword' reach up and out). Each has a mirror extension pattern.

PNF Stretching

TechniqueMethodMechanism
Contract-Relax (CR)Isometric contraction of the tight muscle, relax, then passive stretchAutogenic inhibition via Golgi tendon organ
Hold-Relax (HR)Similar, contraction held against resistance, then stretchAutogenic inhibition
CRACCR followed by active contraction of the antagonistAutogenic + reciprocal inhibition

Matching the Intervention to the Stage of Healing

The single most common MSK intervention question is really a timing question: given this stage, what is most appropriate? In the acute/inflammatory phase (roughly the first days) the goals are protection and pain/edema control—relative rest, gentle PROM/AAROM, isometrics, and modalities for symptom relief. In the subacute/proliferative phase, progress to AROM, light isotonics, and controlled loading to align healing tissue. In the remodeling/chronic phase, load progressively with eccentric and functional, task-specific training to restore strength, power, and return-to-activity capacity.

This staging is why two patients with the 'same' diagnosis get different answers: a day-3 ankle sprain and a six-week ankle sprain call for different interventions. The exam also rewards active over passive: when an item offers a passive modality and an equally available active exercise for a chronic MSK problem, the active, evidence-based choice is usually correct. Modalities are best framed as adjuncts that make active exercise possible (e.g., controlling pain so the patient can move), not as standalone cures.

When progressing resistance, advance only when the patient performs the current level with good form and without a symptom flare; a useful rule is to increase one variable at a time (load, volume, range, or speed) so that any symptom change is interpretable.

Patient Education as an Intervention

The NPTE treats patient education as a legitimate, often preferred intervention rather than an afterthought. Teaching activity modification, a home exercise program, pain-science reassurance for persistent pain, and self-management strategies frequently outperforms a passive modality on 'most appropriate' items, especially for chronic conditions. Effective education is specific and checked for understanding (teach-back), aligns with the patient's goals (salience), and empowers active participation—mirroring the same evidence-based, active-care philosophy that runs through the entire interventions domain.

Test Your Knowledge

A patient has limited shoulder flexion from capsular tightness. Which mobilization grades are MOST appropriate to increase ROM?

A
B
C
D
Test Your Knowledge

Which PNF stretching technique uses autogenic inhibition via the Golgi tendon organ?

A
B
C
D
Test Your Knowledge

In the DeLorme PRE protocol, the three sets are performed:

A
B
C
D
Test Your Knowledge
Ordering

Arrange the therapeutic exercise progression from LEAST to MOST demanding:

Arrange the items in the correct order

1
Isometric
2
Isokinetic
3
AAROM
4
PROM
5
Isotonic eccentric
6
Isotonic concentric
7
AROM
Test Your Knowledge

To improve knee extension ROM, a PT mobilizes the tibia on the femur. Because the tibial plateau is concave, the glide should be applied:

A
B
C
D
Test Your Knowledge

The D2 flexion PNF pattern of the upper extremity includes:

A
B
C
D
Test Your Knowledge

Joint mobilization grades I and II are used primarily for:

A
B
C
D