3.3 Health, Nutrition & Disease

Key Takeaways

  • Health and nutrition account for ~8 items (~13%) of the NEX Science section and blend biology with real-world application.
  • The six classes of nutrients are carbohydrates, proteins, fats, vitamins, minerals, and water; carbs supply 45-65% of calories.
  • Water-soluble vitamins (B-complex, C) are not stored and need daily intake; fat-soluble vitamins (A, D, E, K) are stored and can reach toxic levels.
  • Classic deficiencies: vitamin A to night blindness, C to scurvy, D to rickets, B12 to pernicious anemia, K to bleeding, iron to anemia.
  • Pathogens are bacteria, viruses, fungi, and parasites; viruses are nonliving and must use a host cell to reproduce.
  • Communicable diseases spread person-to-person (TB, influenza); non-communicable diseases (diabetes, heart disease, cancer) do not.
  • Innate immunity is immediate and nonspecific with no memory; adaptive immunity is slower, specific, and forms memory cells.
  • Homeostasis is maintained mainly by negative feedback; positive feedback (labor, clotting) amplifies a change until completion.
Last updated: June 2026

Health and Nutrition on the NEX

Health topics make up roughly 8 items (~13%) of the 60-question Science section. They connect basic biology to patient-care reality, and many are pure recall — fast points if the vitamin-deficiency pairs are memorized.

The Six Essential Nutrients

NutrientFunctionRecommended share
CarbohydratesPrimary, quick energy45-65% of calories
ProteinsBuild/repair tissue, enzymes, immunity10-35% of calories
FatsStored energy, insulation, membranes20-35% of calories
VitaminsRegulate body processesVaries
MineralsBone, fluid balance, nerve signalsVaries
WaterTransport, temperature, digestion~8 cups/day

Carbohydrates provide 4 kcal/g, protein 4 kcal/g, and fat 9 kcal/g — fat is the most calorie-dense, a frequently tested number.

Vitamins: Water-Soluble vs. Fat-Soluble

CategoryMembersKey behavior
Water-solubleB-complex (B1, B2, B3, B5, B6, B7, B9, B12), CNot stored; excess excreted in urine; need daily intake
Fat-soluble (ADEK)A, D, E, KStored in fat and liver; can build to toxic levels

The single most tested vitamin idea: fat-soluble A, D, E, K accumulate and risk toxicity (hypervitaminosis), while water-soluble vitamins are flushed out and rarely toxic. Memorize the deficiency pairs:

NutrientDeficiency disease
Vitamin ANight blindness
Vitamin CScurvy (bleeding gums, poor healing)
Vitamin DRickets (children), osteomalacia (adults)
Vitamin B12Pernicious anemia, neuropathy
Vitamin KExcessive bleeding (clotting fails)
Folic acid (B9)Neural tube defects in pregnancy
Iron (mineral)Iron-deficiency anemia
Calcium (mineral)Osteoporosis

Disease Concepts

Communicable (infectious) diseases spread person to person via pathogens; non-communicable (chronic) diseases do not.

TypeSpreadExamples
CommunicablePerson to personInfluenza, COVID-19, tuberculosis, HIV
Non-communicableGenetics/lifestyleHeart disease, type 2 diabetes, cancer, asthma

Trap: diabetes and heart disease are not contagious — tuberculosis (caused by Mycobacterium tuberculosis) is the communicable answer in most item sets.

PathogenNatureExample diseases
BacteriaLiving prokaryotesStrep throat, UTIs, TB
VirusesNonliving; need a host cellInfluenza, COVID-19, HIV, measles
FungiUni- or multicellularAthlete's foot, ringworm, yeast
ParasitesLive on/in a hostMalaria, tapeworms, lice

The defining viral fact: viruses cannot reproduce on their own and must hijack a host cell — which is also why antibiotics (which target bacteria) do not work against viral infections.

The Immune System

ResponseSpeedSpecificityMemoryExamples
Innate (nonspecific)ImmediateFights all pathogensNoSkin, inflammation, fever, phagocytes
Adaptive (specific)DaysTargets one pathogenYesAntibodies, B cells, T cells

Vaccination trains the adaptive system to make memory cells without causing the disease, so a later real exposure is met quickly — the basis of immunity.

Homeostasis and Feedback

Homeostasis is maintaining a stable internal environment (temperature, pH, glucose, fluids) despite external change.

  • Negative feedback (common): the body reverses a change. Temperature rises, sweating and vasodilation cool the body, then stop. Blood glucose rises, insulin lowers it.
  • Positive feedback (rare): the body amplifies a change until a process completes. Labor contractions trigger more oxytocin and stronger contractions until delivery; blood clotting recruits more platelets until the wound seals.

Trap: body-temperature and blood-sugar control are negative feedback; only completion-driven events like labor and clotting are positive. Chronic-disease risk factors — smoking, inactivity, poor diet, excess alcohol, obesity, and chronic stress — overload these systems and are tied to heart disease, type 2 diabetes, COPD, and certain cancers.

Macronutrients, Calories, and Balanced Intake

Beyond the deficiency tables, the NEX expects a working sense of energy balance. Weight is gained when calories consumed exceed calories burned and lost when the reverse is true. Because fat carries nine kilocalories per gram versus four for carbohydrate and protein, fatty foods are the most calorie-dense and the easiest to over-consume. A balanced plate emphasizes whole grains, vegetables, fruits, lean protein, and water while limiting added sugars, saturated fat, and sodium. Excess sodium raises blood pressure, which links diet directly to the hypertension and heart-disease risk factors above.

Fiber, a non-digestible carbohydrate, supports digestion and helps regulate blood glucose and cholesterol. These ideas connect the chemistry of macromolecules to the health applications nurses use daily.

Disease Transmission and Prevention

When a question describes how an illness spreads, classify the route. Direct contact transmission passes a pathogen through touch or bodily fluids, as with many skin infections and sexually transmitted infections. Droplet transmission spreads through coughing or sneezing over short distances, as with influenza. Airborne transmission lingers in fine particles over longer distances, as with tuberculosis and measles. Vector-borne transmission uses an organism such as a mosquito, as with malaria. Foodborne or waterborne transmission spreads through contaminated intake.

The most effective everyday prevention measure is hand hygiene, followed by vaccination, safe food handling, and isolation of contagious patients. Recognizing the transmission route is often the key to answering an applied health item, because it determines which precaution a nurse would choose.

NLN NEX Science Section — Topic Distribution
Test Your Knowledge

Which of the following vitamins is fat-soluble?

A
B
C
D
Test Your Knowledge

What type of feedback loop regulates body temperature?

A
B
C
D
Test Your Knowledge

Which pathogen is nonliving and must hijack a host cell to reproduce?

A
B
C
D
Test Your KnowledgeMulti-Select

Which of the following are functions of proteins in the body? (Select all that apply)

Select all that apply

Building and repairing tissues
Storing genetic information
Acting as enzymes to catalyze reactions
Primary source of quick energy
Transporting oxygen in the blood (hemoglobin)
Immune defense (antibodies)
Test Your KnowledgeFill in the Blank

The body's ability to maintain a stable internal environment despite changing external conditions is called _____.

Type your answer below

Test Your Knowledge

A deficiency in Vitamin C can lead to:

A
B
C
D
Test Your Knowledge

Which disease is classified as COMMUNICABLE (infectious)?

A
B
C
D
Test Your Knowledge

The innate immune system differs from the adaptive immune system because the innate system:

A
B
C
D
Test Your Knowledge

During a positive feedback loop, the body:

A
B
C
D
Test Your KnowledgeFill in the Blank

The fat-soluble vitamins are A, D, E, and _____.

Type your answer below