5.2 Transmission-Based Precautions and PPE

Key Takeaways

  • Contact Precautions (gown + gloves, private/cohort room) cover MRSA, VRE, C. difficile, scabies, and RSV - any disease spread by direct or indirect touch.
  • Droplet Precautions (surgical mask within 3-6 feet, mask resident during transport) cover influenza, pertussis, mumps, and meningococcal disease.
  • Airborne Precautions require a fit-tested N95 respirator and a negative-pressure airborne infection isolation room (AIIR) with the door closed - used for tuberculosis, measles, varicella, and aerosol-generating procedures on COVID-19 residents.
  • PPE DONNING order is gown -> mask/respirator -> goggles/face shield -> gloves; PPE DOFFING order is gloves -> goggles/face shield -> gown -> mask/respirator -> hand hygiene.
  • OSHA's Respiratory Protection Standard (29 CFR 1910.134) requires N95 fit testing at hire and at least annually thereafter; an N95 that has not been fit tested cannot be relied on for airborne protection.
Last updated: May 2026

Transmission-Based Precautions and PPE

Quick Answer: Three layers of Transmission-Based Precautions sit on top of Standard Precautions: Contact (gown + gloves), Droplet (surgical mask within 3-6 ft), and Airborne (fit-tested N95 + negative-pressure room). The CDC PPE sequence is gown -> mask -> goggles -> gloves to put on, and gloves -> goggles -> gown -> mask -> hand hygiene to take off.

When You Need More Than Standard Precautions

The CDC's 2007 Guideline for Isolation Precautions defines three categories that are added when a resident is known or suspected to have a transmissible infection. The nurse will post a colored sign on the door identifying the precaution category.

Contact Precautions (Yellow / Brown Sign)

Used for organisms spread by direct touch (skin-to-skin) or indirect touch (contaminated bed rails, BP cuff, stethoscope, call light, etc.).

Diseases requiring Contact Precautions:

  • MRSA (methicillin-resistant Staphylococcus aureus)
  • VRE (vancomycin-resistant Enterococcus)
  • C. difficile
  • Scabies and lice (until 24 hours after treatment)
  • RSV (respiratory syncytial virus) in young children
  • Norovirus, E. coli O157:H7, Shigella, hepatitis A
  • Open wounds with copious uncontained drainage

CNA actions:

  1. Private room (or cohort with same-organism residents).
  2. Don gown and gloves before entering. Many facilities require these even for brief social contact.
  3. Dedicate equipment (BP cuff, thermometer, stethoscope) to the room.
  4. Remove gown and gloves inside the room before leaving and perform hand hygiene immediately.
  5. For C. diff and norovirus, use soap and water for hand hygiene (alcohol rub will not kill spores).

Droplet Precautions (Pink / Green Sign)

Large respiratory droplets (>5 microns) travel only 3-6 feet before settling. They do not stay airborne on currents, so a regular surgical mask is sufficient.

Diseases requiring Droplet Precautions:

  • Influenza
  • Pertussis (whooping cough)
  • Mumps
  • Rubella
  • Meningococcal disease (Neisseria meningitidis)
  • Group A Streptococcus (pharyngitis, scarlet fever) until 24 hours of antibiotics

CNA actions:

  1. Private room (or 3+ feet separation between cohort beds with a curtain).
  2. Don a surgical mask before entering, or whenever within 3-6 ft of the resident.
  3. Mask the RESIDENT with a surgical mask whenever they leave the room (transport to dialysis, X-ray, etc.).
  4. Limit movement of the resident outside the room.

Airborne Precautions (Blue Sign)

Small droplet nuclei (<5 microns) and aerosols can drift on air currents and stay suspended for hours - a surgical mask is NOT enough.

Diseases requiring Airborne Precautions:

  • Tuberculosis (M. tuberculosis)
  • Measles (rubeola)
  • Varicella (chickenpox) and disseminated zoster (shingles)
  • SARS-CoV-2 (COVID-19) during aerosol-generating procedures such as intubation, bronchoscopy, or nebulizer treatments

CNA actions:

  1. Airborne Infection Isolation Room (AIIR) - negative pressure, 6-12 air changes per hour, air exhausted outside or HEPA filtered, door kept closed.
  2. Wear a fit-tested N95 respirator (or higher, such as a PAPR) - NOT a surgical mask.
  3. Per OSHA's Respiratory Protection Standard (29 CFR 1910.134), an N95 must be fit-tested at hire and annually thereafter, plus whenever weight, facial structure, or dentition change. CNAs who have not been fit-tested cannot rely on an N95 for protection.
  4. If the resident must leave the room, place a surgical mask on the resident and notify the receiving department in advance.
  5. For measles or varicella, ideally only immune (vaccinated) staff should enter.

Combined Precautions

Some diseases require more than one category. For example, chickenpox requires both Airborne and Contact, and SARS-CoV-2 during aerosol-generating procedures requires Airborne + Contact + Eye Protection. Always read the door sign rather than relying on memory.

PPE Donning Sequence (Putting On)

The CDC's PPE sequence (which OBRA also expects on the NNAAP skills test) is:

StepPPEWhy this order
1GownLargest item; tied at neck and waist with back overlapping
2Mask or N95 respiratorApply before goggles so straps lie flat; perform a user seal check on N95
3Goggles or face shieldSettled on top of mask straps to prevent slippage
4GlovesLast - extend cuffs over the wrists of the gown

PPE Doffing Sequence (Taking Off)

Doffing is where most self-contamination happens. The CDC sequence assumes the gown and gloves are the most contaminated items.

StepPPEKey point
1GlovesGlove-to-glove, then skin-to-skin (peel without touching outside)
2Goggles or face shieldLift by the clean headband or earpieces, never the front
3GownUnfasten ties; roll inside-out away from the body; do not shake
4Mask or respiratorLift bottom strap first, then top - never touch the front
5Hand hygieneAlways the final step (soap and water if contaminated or for C. diff/norovirus)

Memory aid: "GGGG-H" to doff - Gloves, Goggles, Gown, mask (Goes off last with one hand on each strap), Hand hygiene.

Disposal

Single-use PPE is disposed of inside the resident's room in a lined trash can or, when contaminated with blood or OPIM, in a biohazard bag. Reusable eye protection is cleaned and disinfected per facility protocol. Never wear PPE out of the room into the hallway.

Test Your Knowledge

A North Carolina CNA is assigned to a resident newly admitted with pulmonary tuberculosis. The room has a sign reading 'Airborne Precautions.' Which combination of actions meets CDC and OSHA requirements?

A
B
C
D
Test Your Knowledge

Place these PPE doffing steps in the correct CDC sequence: (1) mask/respirator, (2) gloves, (3) hand hygiene, (4) gown, (5) goggles.

A
B
C
D