100+ Free SPLE (Pharmacist) Practice Questions
Pass your Saudi Pharmacist Licensure Examination (SPLE - Pharmacist) (CBT via Prometric) exam on the first try — instant access, no signup required.
A pharmacoepidemiology team wants the strongest design to establish that a drug causes a beneficial outcome, minimizing bias and confounding. Which study design provides the highest level of evidence for a causal effect?
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Sample SPLE (Pharmacist) Practice Questions
Try these sample questions to test your SPLE (Pharmacist) exam readiness. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.
1A pharmacist explains to a student that the loop of Henle in the nephron is the primary site responsible for generating the medullary concentration gradient that allows the kidney to produce concentrated urine. Which transporter in the thick ascending limb is the molecular target of loop diuretics such as furosemide?
2During a biochemistry review, a pharmacist is asked which enzyme catalyzes the rate-limiting and committed step of glycolysis, and is the key allosteric control point inhibited by ATP and citrate. Which enzyme is this?
3A patient with a known IgE-mediated penicillin allergy receives a beta-lactam and develops urticaria, bronchospasm and hypotension within minutes. According to the Gell and Coombs classification, what type of hypersensitivity reaction is this?
4A pharmacist counsels a patient that a live attenuated vaccine generates strong, long-lasting immunity. Which component of adaptive immunity is primarily responsible for producing neutralizing antibodies after vaccination?
5A microbiology lecture distinguishes bacteria by their cell wall structure using the Gram stain. Which structural feature is responsible for the endotoxin activity and the characteristic pink appearance of Gram-negative bacteria after Gram staining?
6A pharmacist reviews the central dogma of molecular biology with a pharmacogenomics fellow. Which process is correctly described as the synthesis of a complementary mRNA strand from a DNA template, carried out by RNA polymerase?
7A pharmacist explains autonomic physiology: stimulation of beta-1 adrenergic receptors in the heart increases heart rate and contractility. Through which second messenger does beta-1 receptor activation primarily exert this effect?
8A patient receiving an aminoglycoside develops fever, chills and hypotension, and laboratory cultures grow a Gram-negative rod. The clinical picture is driven by lipid A. Which term best describes this bacterial component responsible for the septic response?
9A clinical pharmacist reviews acid-base physiology. A patient with severe vomiting loses gastric hydrochloric acid. Which primary acid-base disturbance would you expect?
10A pharmacogenomics discussion notes that some patients are 'poor metabolizers' due to inherited variation in a gene encoding a drug-metabolizing enzyme. This is an example of which underlying molecular principle?
About the SPLE (Pharmacist) Exam
The SPLE is the mandatory licensure examination for pharmacists seeking to practice or enter postgraduate training in Saudi Arabia. It is a computer-based, multiple-choice exam of 200 scored questions (plus up to 10% pilot items) delivered by Prometric, and assesses readiness across four content areas weighted 10/35/20/35.
Assessment
200 scored MCQs delivered in two parts of 100 questions each, plus up to 10% pilot (unscored) items; recall and scenario-based question types.
Time Limit
4 hours 30 minutes total (two 120-minute parts with a 30-minute break)
Passing Score
536 on a 200-800 reporting scale (about 67%), set by the SCFHS Central Assessment Committee
Exam Fee
Prometric fee set by SCFHS and varies by location (commonly around USD 220-250 for SLE-titled exams); verify current fee on the official SCFHS/Prometric portal. (Saudi Commission for Health Specialties (SCFHS))
SPLE (Pharmacist) Exam Content Outline
Basic Biomedical Sciences
Physiology, biochemistry and enzymology, microbiology related to human disease, immunology, and molecular genetics that form the foundation for pharmacogenomics.
Pharmaceutical Sciences
Medicinal chemistry and ADME, pharmacology and toxicology, pharmacognosy and dietary supplements, pharmaceutics, pharmacokinetics, and sterile/nonsterile compounding with pharmaceutical calculations.
Social/Behavioral/Administrative Sciences
Saudi health care delivery and public health, pharmacoepidemiology and pharmacovigilance, pharmacoeconomics, pharmacy management, Saudi pharmacy law and regulatory affairs, biostatistics, ethics, communication, and dispensing systems.
Clinical Sciences
Drug information and evidence-based practice, clinical pharmacokinetics, clinical pharmacogenomics, disease prevention and immunization, patient assessment, and clinical pharmacology with therapeutic decision-making across special populations.
How to Pass the SPLE (Pharmacist) Exam
What You Need to Know
- Passing score: 536 on a 200-800 reporting scale (about 67%), set by the SCFHS Central Assessment Committee
- Assessment: 200 scored MCQs delivered in two parts of 100 questions each, plus up to 10% pilot (unscored) items; recall and scenario-based question types.
- Time limit: 4 hours 30 minutes total (two 120-minute parts with a 30-minute break)
- Exam fee: Prometric fee set by SCFHS and varies by location (commonly around USD 220-250 for SLE-titled exams); verify current fee on the official SCFHS/Prometric portal.
Keys to Passing
- Complete 500+ practice questions
- Score 80%+ consistently before scheduling
- Focus on highest-weighted sections
- Use our AI tutor for tough concepts
SPLE (Pharmacist) Study Tips from Top Performers
Frequently Asked Questions
How many questions are on the SPLE and how long is it?
The SPLE contains 200 scored multiple-choice questions (plus up to 10% pilot items), delivered in two 100-question parts. The total testing time is 4 hours 30 minutes, including a scheduled 30-minute break between the two parts.
What score do I need to pass the SPLE?
The SCFHS Central Assessment Committee set the passing score at 536 on a reporting scale of 200 to 800, which is approximately 67%. Results for SLE-titled exams are typically posted within 2 to 6 weeks of the end of the testing window.
What topics does the SPLE cover and how are they weighted?
The SPLE blueprint covers four areas: Basic Biomedical Sciences (10%), Pharmaceutical Sciences (35%), Social/Behavioral/Administrative Sciences (20%), and Clinical Sciences (35%). Distributions may vary by up to plus or minus 5% per area.
Who administers the SPLE and where is it taken?
The SPLE is administered by Prometric on behalf of the Saudi Commission for Health Specialties (SCFHS). It is a computer-based test taken at approved Prometric test centers inside Saudi Arabia and internationally, after obtaining an SCFHS eligibility number through Mumaris+.