Free Practice Questions for NPC B.Pharm

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Nepal Pharmacy Council Pharmacy Assistant Licensure Examination

Practice Questions100 questions

Exam Review

Key Facts: NPC B.Pharm Exam

150

MCQs on the exam

150 min

Session length (NPC timetables)

50%

Reported pass mark

NPR 3,000

Examination fee

The NPC pharmacist name registration exam is a 150-question MCQ test sat in a 150-minute session, with a reported pass mark of 50%. The 31st examination's results were published in Bhadra 2083 (September 2026). Pharmacology, pharmaceutical technology, pharmacognosy/medicinal chemistry and community/social pharmacy each carry about 25 questions.

Sample NPC B.Pharm Practice Questions

Try these sample questions to review concepts for the NPC B.Pharm exam. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.

1Which pharmacokinetic parameter relates the total amount of drug in the body to its plasma concentration?

A.Total body clearance

B.Elimination half-life

C.Volume of distribution

D.Area under the curve (AUC)

Explanation: Vd = amount of drug in the body ÷ plasma concentration. A large Vd (well above total body water) means the drug is extensively bound in tissues, and Vd is used to calculate loading doses.

2How do ACE inhibitors such as enalapril lower blood pressure?

A.By blocking angiotensin II at AT1 receptors

B.By blocking vascular L-type calcium channels

C.By directly inhibiting the enzyme renin

D.By reducing angiotensin II formation

Explanation: ACE inhibitors reduce formation of the vasoconstrictor angiotensin II and also slow bradykinin breakdown. Accumulated bradykinin explains the dry cough and, rarely, angioedema.

3Which antibiotic binds the D-Ala-D-Ala end of peptidoglycan precursors, blocking cell wall synthesis?

A.Penicillin G

B.Vancomycin

C.Ciprofloxacin

D.Gentamicin

Explanation: Vancomycin, a glycopeptide, caps the D-alanyl-D-alanine terminus and prevents transglycosylation and transpeptidation. Enterococci that change the terminus to D-Ala-D-Lac become vancomycin-resistant.

4Which toxicities of aminoglycosides such as gentamicin make therapeutic drug monitoring important?

A.Nephrotoxicity and ototoxicity

B.Aplastic anaemia and grey baby syndrome

C.Tendon rupture and QT prolongation

D.Pulmonary fibrosis and corneal deposits

Explanation: Aminoglycosides accumulate in proximal tubular cells and inner ear fluids, causing kidney injury and cochlear or vestibular damage. Levels, renal function and duration of therapy are monitored.

5A patient stable on warfarin starts rifampicin for tuberculosis. What is the expected effect?

A.INR rises because rifampicin inhibits CYP2C9

B.Warfarin is displaced from albumin, causing acute toxicity

C.Renal excretion of warfarin is blocked

D.INR falls because rifampicin induces warfarin metabolism

Explanation: Rifampicin is a strong inducer of CYP enzymes, including CYP2C9 and CYP3A4, so warfarin is cleared faster and the INR drops. The INR must be monitored closely and the dose adjusted, including when rifampicin is stopped.

6Which class of oral antidiabetic drugs lowers glucose by blocking sodium-glucose cotransporter 2 in the proximal tubule?

A.Gliptins, such as sitagliptin

B.Sulfonylureas, such as gliclazide

C.Gliflozins, such as empagliflozin

D.Glitazones, such as pioglitazone

Explanation: SGLT2 inhibitors reduce renal glucose reabsorption, causing glycosuria. They also have heart failure and kidney benefits, but can cause genital infections and, rarely, euglycaemic ketoacidosis.

7What is the antidote for paracetamol overdose, given to restore glutathione and detoxify NAPQI?

A.Naloxone

B.N-acetylcysteine

C.Flumazenil

D.Pralidoxime

Explanation: N-acetylcysteine replenishes hepatic glutathione, which conjugates the toxic metabolite NAPQI. It is most effective when started within about 8 hours of ingestion, guided by the plasma level where available.

8How does digoxin increase the force of contraction of the failing heart?

A.It stimulates cardiac beta-1 adrenoceptors

B.It inhibits phosphodiesterase-3 in myocytes

C.It inhibits the sodium-potassium pump

D.It opens potassium channels in the myocardium

Explanation: Inhibiting the sodium pump raises intracellular sodium, which reduces calcium removal by the Na+/Ca2+ exchanger and increases calcium available for contraction. Hypokalaemia increases digoxin binding and toxicity.

9Dolutegravir, part of the TLD first-line HIV regimen used in Nepal, belongs to which drug class?

A.Integrase strand transfer inhibitors

B.Nucleoside reverse transcriptase inhibitors

C.Non-nucleoside reverse transcriptase inhibitors

D.Protease inhibitors

Explanation: Dolutegravir blocks HIV integrase, preventing viral DNA from being inserted into the host genome. In TLD it is combined with tenofovir and lamivudine, which are NRTIs.

10Which first-line antitubercular drug causes peripheral neuropathy that is prevented by giving pyridoxine?

A.Rifampicin

B.Pyrazinamide

C.Ethambutol

D.Isoniazid

Explanation: Isoniazid interferes with pyridoxine (vitamin B6) metabolism, so pyridoxine is given especially to people at risk, such as those with malnutrition, diabetes, HIV or alcohol use, and during pregnancy.

About the NPC B.Pharm Exam

The NPC Pharmacist Licensure Examination is the Nepal Pharmacy Council's Name Registration Examination for B.Pharm graduates; passing it is required for registration as a pharmacist in Nepal. NPC publishes the syllabus and English-language model MCQs, and this free practice bank follows the seven syllabus areas in proportion.

Exam sponsor: Nepal Pharmacy Council. The requirements and fees below concern the certification or admission exam, separate from our free practice resources.

Assessment

150 multiple-choice questions in 150 minutes. The NPC pharmacist syllabus covers seven areas: pharmacognosy and medicinal chemistry; analysis and instrumentation; pharmaceutical technology and biopharmaceutics; pharmacology and therapeutics; clinical and hospital pharmacy; forensic pharmacy; and community, social pharmacy and public health. Candidates complete biometric verification and may bring only the admit card and a photo ID.

Time Limit

150 minutes (2 hours 30 minutes)

Passing Score

50% (75 of 150), as reported by published exam guides

Exam / Certification Fees

NPR 3,000

Exam sponsor website

Fees, eligibility, and exam policies can change. Confirm them with the exam sponsor before applying or paying.

Official sources

Our practice resources: topics covered

We aim to reflect publicly available exam outlines and topic information in our study resources. Coverage, format, and difficulty may differ from the actual exam, and we cannot guarantee that every detail is accurate or current. Confirm exam requirements, fees, and policies with the official exam sponsor.

About 25 of 150 questions

Pharmacognosy, Medicinal Chemistry & Natural Product Chemistry

Crude drugs and phytochemistry, medicinal plants of Nepal, structure-activity relationships and drug synthesis.

About 15 of 150 questions

Pharmaceutical Analysis & Instrumentation

Titrimetry, spectroscopy, chromatography, validation and quality control.

About 25 of 150 questions

Pharmaceutical Technology, Biopharmaceutics & Dosage Form Design

Unit operations, solid, liquid, semisolid and sterile dosage forms, stability, packaging and pharmacokinetics.

About 25 of 150 questions

Pharmacology & Therapeutics

Drug mechanisms, adverse effects, interactions and evidence-based therapy across organ systems.

About 20 of 150 questions

Clinical Pharmacy & Hospital Pharmacy

Pharmaceutical care, therapeutic drug monitoring, pharmacovigilance, formulary and hospital store management.

About 15 of 150 questions

Forensic Pharmacy (Pharmacy laws & ethics)

Drugs Act 2035 and its regulations, Narcotic Drugs (Control) Act 2033, Nepal Pharmacy Council Act 2057, National Drug Policy and professional ethics.

About 25 of 150 questions

Community pharmacy, social pharmacy & public health

Dispensing and counselling, Good Pharmacy Practice, primary health care, pharmacoeconomics and pharmacoepidemiology.

Preparing for the NPC B.Pharm Exam

What You Need to Know

Passing score: 50% (75 of 150), as reported by published exam guides
Assessment: 150 multiple-choice questions in 150 minutes. The NPC pharmacist syllabus covers seven areas: pharmacognosy and medicinal chemistry; analysis and instrumentation; pharmaceutical technology and biopharmaceutics; pharmacology and therapeutics; clinical and hospital pharmacy; forensic pharmacy; and community, social pharmacy and public health. Candidates complete biometric verification and may bring only the admit card and a photo ID.
Time limit: 150 minutes (2 hours 30 minutes)
Exam / certification fees: NPR 3,000 Official sources

Using Our Practice Resources

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NPC B.Pharm: Suggested Study Strategy

1Start from the NPC syllabus and model MCQs: four of the seven areas carry about 25 questions each, so pharmacology, pharmaceutical technology, pharmacognosy/medicinal chemistry and community/social pharmacy deserve the most time.

2Read the English text of the Drugs Act 2035 rather than summaries: drug categories (Ka, Kha, Ga), registration and certificate validity, inspectors and analysts, and penalties.

3Practise calculations such as loading and maintenance doses, creatinine clearance, Beer-Lambert assays and pharmacoeconomic ratios.

4Know Nepal-specific content such as major medicinal plants, the DDA and National Medicines Laboratory, the National List of Essential Medicines and the hospital pharmacy guideline.

Frequently Asked Questions

How many questions are on the NPC pharmacist exam and how long is it?

Published guides based on the NPC syllabus describe 150 MCQs. NPC timetables for recent sittings scheduled 150-minute sessions (for example 11:00 to 1:30 for the 30th examination).

What is the passing score?

Exam guides report a pass mark of 50%, or 75 correct answers out of 150. Check the current NPC notice and admit card for the rules that apply to your sitting.

What can I bring on exam day?

NPC notices allow only the admit card and a government-issued photo ID. Candidates complete biometric verification, and those who do not are not allowed to sit the exam.

Does Nepal Pharmacy Council publish model questions?

Yes. The NPC syllabus page provides the B.Pharm syllabus and a set of English-language model MCQs.