Free MCAT Chem/Phys Exam Prep
MCAT Chemical and Physical Foundations of Biological Systems
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What You'll Study
14 chapters covering the exam topics in this guide
Introduction
2 sections
Chapter 1: Translational Motion, Forces, Work & Energy
6 sections
Chapter 2: Fluids & Gas Phase
4 sections
Chapter 3: Electrochemistry & Circuits
5 sections
Chapter 4: Light & Sound
4 sections
Chapter 5: Atomic Structure & the Periodic Table
5 sections
Chapter 6: Water, Solutions & Acid-Base Equilibria
4 sections
Chapter 7: Covalent Bonding & Intermolecular Forces
4 sections
Chapter 8: Separations & Purification Methods
2 sections
Chapter 9: Biomolecules I — Nucleic Acids, Amino Acids & Proteins
6 sections
Chapter 10: Biomolecules II — Carbohydrates & Organic Functional Groups
7 sections
Chapter 11: Enzymes & Bioenergetics
4 sections
Chapter 12: Thermodynamics, Kinetics & Chemical Equilibrium
5 sections
Chapter 13: Integration, Strategy & Final Review
4 sections
MCAT Chem/Phys Exam Details
MCAT Chemical and Physical Foundations of Biological Systems
Administered by Association of American Medical Colleges (AAMC)
Exam Content Breakdown
Based on the official Association of American Medical Colleges (AAMC) content outline
Atomic structure, electron configuration, periodic trends, chemical bonding (ionic, covalent, metallic), stoichiometry, ideal and real gases, solutions and colligative properties, acids and bases (Brønsted–Lowry, pKa, buffers), chemical equilibrium (Kc, Kp, Le Chatelier's principle), thermodynamics (ΔH, ΔS, ΔG, Hess's law), kinetics (rate laws, Arrhenius equation, half-life), and electrochemistry (galvanic/electrolytic cells, Nernst equation, Faraday's laws).
Translational kinematics and dynamics (Newton's laws, forces, friction), energy and work (conservation of energy, power), momentum and collisions, fluids (Bernoulli's equation, continuity, hydrostatic pressure, surface tension, buoyancy), thermodynamics (heat, PV work, heat capacity), waves and sound (wavelength, frequency, Doppler effect, standing waves), electrostatics (Coulomb's law, electric fields and potential), circuits (Ohm's law, series/parallel resistors, capacitance), and light/optics (reflection, refraction, Snell's law, lens equation, wave optics). Atomic and nuclear physics: radioactive decay, half-life, photoelectric effect, de Broglie wavelength.
Functional group identification and reactivity (alcohols, aldehydes, ketones, carboxylic acids, esters, amines, amides), stereochemistry (chirality, R/S, enantiomers, diastereomers, meso compounds), alkene and alkyne reactions (Markovnikov addition, electrophilic addition), substitution and elimination reactions (SN1, SN2, E1, E2), carbonyl chemistry, separations and purification (TLC, column chromatography, distillation, recrystallization), and spectroscopy (IR, ¹H NMR, mass spectrometry) as applied to biological molecules.
Amino acid structure, ionization (pKa, isoelectric point, zwitterion), protein structure and function, enzyme kinetics (Michaelis–Menten, Km, Vmax, competitive/noncompetitive/uncompetitive inhibition, Lineweaver–Burk plots), lipid structure and biological membranes, metabolic processes framed through physical and chemical principles (acid–base physiology, bicarbonate buffer system, osmotic pressure in biological contexts).
Biological systems contexts for physical/chemical principles: cardiovascular fluid dynamics, respiratory mechanics (surface tension, pulmonary surfactant), renal filtration (Starling equation), nerve conduction (membrane potential), and cellular chemistry — always tested through a physics or chemistry lens.
What's Included
14 Chapters
Complete exam coverage
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