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6.3 HCPCS Level II

Key Takeaways

  • HCPCS Level II codes are alphanumeric (one letter plus four digits) and report products, supplies, and services not described by CPT — durable medical equipment, drugs, ambulance transport, orthotics, and prosthetics.
  • The leading letter signals the code section: E for durable medical equipment, J for injectable drugs, L for orthotics and prosthetics, A for transportation and medical/surgical supplies, and V for vision and hearing.
  • Modifier JW reports the discarded amount of a single-use drug vial, and modifier JZ attests that zero units were discarded; Medicare requires one of the two on applicable single-dose drug claims.
  • Therapy modifiers identify the discipline delivering the service: GP for physical therapy, GO for occupational therapy, and GN for speech-language pathology.
  • HCPCS Level II is maintained by CMS and updated quarterly, so billers must use the code set in effect on the date of service.
Last updated: May 2026

What HCPCS Level II Covers

HCPCS stands for the Healthcare Common Procedure Coding System. It has two levels: Level I is CPT (the AMA code set), and Level II is the alphanumeric code set maintained by the Centers for Medicare & Medicaid Services (CMS). HCPCS Level II reports items and services CPT does not describe — primarily products, supplies, and non-physician services.

A HCPCS Level II code is one letter followed by four digits (for example, J1885 for injectable ketorolac). Billers encounter these codes on durable medical equipment (DME) claims, drug claims, ambulance claims, and orthotic and prosthetic claims.

Letter Sections

The leading letter tells you the category of the item or service:

LetterSection
ATransportation services (ambulance), and medical/surgical supplies
BEnteral and parenteral therapy
COutpatient Prospective Payment System (OPPS) pass-through items
EDurable medical equipment (DME)
JDrugs administered other than by the oral method (injectable/infused)
KTemporary DME codes assigned by the DME MAC
LOrthotic and prosthetic procedures and devices
VVision services and hearing services

Knowing the letter section helps a biller route a claim to the correct payer or contractor — for example, E and K codes typically go to the DME Medicare Administrative Contractor (DME MAC) rather than the local Part B carrier.

Drug Waste Modifiers: JW and JZ

When a single-use (single-dose) drug vial is larger than the dose administered, the unused portion is discarded drug waste. Medicare requires the discarded amount to be accounted for:

  • JW — appended to a separate claim line reporting the number of units discarded.
  • JZ — attests that no amount was discarded (zero waste).

On applicable single-dose drug claims, Medicare expects either JW or JZ on every line; a missing waste modifier can trigger a denial or a refund request.

Therapy Discipline Modifiers: GP, GO, GN

When rehabilitative therapy services are billed, the payer needs to know which discipline performed the service. These modifiers identify the plan of care:

  • GP — services delivered under a physical therapy plan of care
  • GO — services delivered under an occupational therapy plan of care
  • GN — services delivered under a speech-language pathology plan of care

Missing or mismatched therapy modifiers cause denials, because the payer cannot tie the service to the correct benefit category or therapy cap tracking.

A Biller's Quarterly Discipline

CMS updates HCPCS Level II quarterly, with the largest release effective January 1. Drug codes (J codes) and DME codes change frequently. A biller must always apply the code set in effect on the date of service, not the date the claim is keyed.

Test Your Knowledge

A physician administers an injectable drug from a single-dose vial. The full vial was used and nothing was discarded. Which HCPCS modifier should the biller append to the drug line?

A
B
C
D
Test Your KnowledgeMatching

Match each HCPCS Level II section letter to the category of item or service it represents.

Match each item on the left with the correct item on the right

1
E
2
J
3
L
4
V