13.2 Injection Techniques, Failures & Complications

Key Takeaways

  • Infiltration works best where cortical bone is thin (maxilla); IANB targets the mandibular foramen for mandibular molar pulpal anesthesia, often with a separate long buccal injection for molar buccal gingiva.
  • PSA anesthetizes maxillary molars but may miss the mesiobuccal root of the first molar and carries pterygoid plexus hematoma risk; mental blocks soft tissue, while incisive technique drives solution into the foramen for pulpal effect.
  • Prevent needle breakage by not bending or hubbing needles; retrieve visible fragments immediately and refer for imaging-guided removal if lost in tissue.
  • Facial nerve paralysis after IANB usually means LA entered the parotid—reassure, protect the eye, expect recovery with drug offset; manage hematoma and trismus supportively.
  • Systemic LA toxicity progresses from CNS prodromes (metallic taste, tinnitus, twitching) to seizures and cardiovascular collapse—prevent with aspiration, slow injection, and MRD limits; manage with oxygen, airway support, benzodiazepines for seizures, and advanced cardiac care.
Last updated: July 2026

13.2 Injection Techniques, Failures & Complications

Quick Answer: Match technique to anatomy: infiltration near apex for maxillary (and many mandibular) teeth; IANB for mandibular molars when dense cortical bone blocks infiltration; PSA for maxillary molars (mind the pterygoid plexus); mental/incisive for premolars/anterior mandible. Failures come from anatomy, infection, inadequate volume, or wrong nerve. Complications include needle breakage, hematoma, facial nerve paralysis, trismus, paresthesia, and systemic LA toxicity (CNS excitation → depression → cardiovascular collapse).

Technique questions on the AFK link head-and-neck anatomy to safe injection: where the needle tip should be, which teeth go numb, why a block fails, and how to manage the common adverse events. Review CN V divisions (V2, V3) alongside this section.

Infiltration Anesthesia

Supraperiosteal (infiltration) deposits LA near the apex of the target tooth so the solution diffuses through porous bone to terminal nerve branches.

FeatureDetail
Best sitesMaxillary teeth (thin cortical plate); mandibular incisors; often mandibular premolars; articaine infiltration may anesthetize many mandibular teeth that lidocaine infiltration cannot
Technique keysStretch mucosa, bevel toward bone, deposit near apex, aspirate when deep, slow injection
AdvantagesSimple, low complication rate, hemostasis if vaso used, limited soft-tissue numbness outside field
FailuresDense bone, infection/low pH, insufficient volume, deposition too far from apex, accessory innervation
Contraindication relativeAcute abscess at injection site—prefer block proximal to infection plus drainage/antibiotics as indicated

Intraseptal, PDL (intraligamentary), and intraosseous injections are supplemental when conventional infiltration/block fails—small volumes, slow injection, risk of post-op bite trauma or selective high-pressure effects; useful for “hot” teeth and endodontic emergencies.

Inferior Alveolar Nerve Block (IANB / Mandibular Block)

The inferior alveolar nerve (V3) enters the mandibular foramen on the medial ramus; LA near this site anesthetizes mandibular teeth to the midline on that side, plus typically lower lip and chin skin via mental nerve (continuation), with lingual nerve often anesthetized if solution spreads (tongue/floor of mouth).

ElementTeaching points
LandmarksCoronoid notch (greatest concavity on anterior ramus), pterygomandibular raphe, occlusal plane of mandibular teeth; height of injection ~6–10 mm above mandibular occlusal plane in adults (adjust for child/edentulous)
TargetSoft tissue superior to mandibular foramen, before nerve enters bone
NeedleLong (≈32 mm) 25- or 27-gauge common; advance until bone gently contacted, withdraw slightly, aspirate, deposit
Teeth anesthetizedAll mandibular teeth on side (pulpal) if successful; soft tissue: buccal mucosa anterior to mental foramen via mental nerve; buccal nerve separate for molar buccal gingiva
Need for long buccalYes for surgical procedures on mandibular molars’ buccal soft tissue
OnsetOften 3–5+ minutes; lip numbness is a useful (not infallible) sign

Common IANB failures and fixes

CauseFix / note
Deposition too lowRe-inject higher toward mandibular foramen level
Deposition too far anteriorDeeper approach toward bone of ramus; check medial direction
Accessory innervation (mylohyoid, cervical)Supplemental infiltration, Gow-Gates, Akinosi-Vazirani, or PDL/intraosseous
Bifid IAN / anatomic variationAlternate block techniques; imaging if chronic failure
“Hot” irreversible pulpitisVolume, wait time, articaine infiltration supplement, intraosseous, sedation adjuncts
Cross-innervation of midline incisorsContralateral infiltration

Gow-Gates (higher V3 trunk) and Akinosi-Vazirani (closed-mouth) are alternative mandibular blocks for failures or trismus—recognize names and indications more than millimeter recipes on AFK.

Positive aspiration on IANB is relatively common (inferior alveolar vessels)—redirect and re-aspirate; never inject if blood aspirated into cartridge without repositioning.

Posterior Superior Alveolar (PSA) Nerve Block

The PSA nerves supply maxillary molars (often except mesiobuccal root of first molar, which may need MSA or infiltration).

FeatureDetail
IndicationMultiple maxillary molars; when infiltration inadequate
Needle pathMucobuccal fold over second molar; upward, inward, backward (~45° each plane teaching) along posterior maxilla
DepthShort needle often preferred to reduce over-insertion risk; ~16 mm typical adult teaching depth—do not hub
Major riskHematoma from pterygoid plexus of veins (± maxillary artery) → rapid cheek swelling
AspirationCritical; high vascularity
MB root of #16/26Often needs additional infiltration or MSA block

Management of PSA hematoma: stop injection, apply firm pressure, ice, reassure (self-limiting discoloration over days), postpone further deep injections in area, document, analgesics as needed; rare airway threat only if massive—monitor.

Mental / Incisive Nerve Block and Other Maxillary Blocks

BlockTarget / use
Mental nerve blockMental foramen (usually between apices of mandibular premolars); soft tissue of lip/chin/buccal gingiva anteriorly—not reliable pulpal for teeth unless solution enters foramen as incisive block
Incisive nerve blockMental block + digital pressure to drive LA into canal → pulpal anesthesia of premolars ± anterior teeth on that side
MSAPremolars and MB root of maxillary first molar when present
ASA / infraorbitalMaxillary anterior teeth and supporting tissues
Greater palatine / nasopalatinePalatal soft tissue for surgery; very painful if not topped up carefully—topical + slow pressure
Maxillary (V2) blockEntire maxillary quadrant; advanced technique (high tuberosity or greater palatine canal approaches)—specialist comfort zone

Needle Breakage

Breakage is rare with modern disposable needles but still tested.

Risk factorPrevention / response
Bending needle before insertionNever intentionally bend; change direction by withdrawing almost fully
Hubbing the needle (insertion to hub)Leave a visible portion outside tissue for retrieval if fracture
Sudden patient movementStable hand rests; warn patient; good communication
Using 30-gauge long needles for deep blocksPrefer appropriate gauge/length for depth (25/27 long for IANB)
If needle breaks and is visibleRetrieve with hemostat immediately if end protrudes
If needle lost in tissueDo not dig blindly; calm patient, map location, refer for surgical removal (often imaging-guided); document thoroughly

Hematoma, Trismus, Facial Nerve Paralysis, Paresthesia

Hematoma

Extravasation of blood into tissues after vessel nicking. PSA and IANB/infraorbital regions classic. Swelling may be rapid. Manage with pressure, ice first 4–6 hours, then heat after 24–48 h in many protocols, analgesics, warn about ecchymosis lasting 7–14 days, infection rare.

Trismus

Limited opening from spasm/inflammation of medial pterygoid (IANB path) or hematoma/infection. Manage with heat, analgesics/NSAIDs, soft diet, gentle physiotherapy/opening exercises; rule out infection if delayed worsening with fever.

Facial nerve paralysis

If LA is deposited into the parotid gland (too far posterior on IANB, missing bone contact), CN VII branches may be anesthetized → unilateral facial droop, inability to close eye.

ActionDetail
ReassureTemporary—duration of soft-tissue anesthesia hours
Eye careTape eye closed or use lubricant if blink lost; protect cornea
DocumentExplain transient motor block vs stroke (no other neuro deficits; recent dental injection context)
PreventionAlways contact bone on IANB before depositing full volume; correct depth/angulation

Paresthesia / dysesthesia

Prolonged altered sensation after LA (especially reported with some 4% solutions near lingual/IAN—association debated). Most resolve over weeks–months; persistent cases need specialist evaluation, mapping, and possible microsurgical referral. Always document pre-existing neuropathy.

Other local complications

  • Soft-tissue injury (lip/tongue chewing) especially children after long-acting blocks—warn caregivers
  • Infection rare with sterile technique; avoid injecting through infected tissue when possible
  • Epithelial desquamation / sterile abscess from topical or high concentration
  • Ocular signs (diplopia, temporary blindness rare) from intra-arterial injection or diffusion—stop, monitor, ophthalmology if persistent

Local Anesthetic Systemic Toxicity (LAST)

Toxicity follows intravascular injection or absolute overdose (especially children). Severity scales with plasma concentration and rate of rise.

Classic progression (CNS then CV)

StageClinical features
Early CNS excitationCircumoral numbness, metallic taste, tinnitus, lightheadedness, visual/auditory disturbance, anxiety, muscle twitching
Later CNSSeizures, then CNS depression: drowsiness, unconsciousness, respiratory arrest
CardiovascularInitially hypertension/tachycardia possible; then myocardial depression, bradycardia, vasodilation, hypotension, ventricular arrhythmias, asystole—bupivacaine especially cardiotoxic
Biphasic teachingExcitation → depression; not every patient shows a neat sequence

Prevention

  • Know and respect MRD (Section 13.1)
  • Aspirate in two planes when indicated; inject slowly
  • Use lowest effective dose and concentration
  • Fractionate doses; communicate with patient during injection
  • Extra caution: small children, elderly, heart failure, liver disease, hypoxia, acidosis (lower seizure threshold)

Management principles (AFK-level)

  1. Stop injection; call for help / activate emergency response as needed
  2. ABC: airway, breathing, circulation; 100% oxygen; ventilatory support
  3. Position supine; monitor vitals
  4. Seizures: benzodiazepines per emergency protocol (e.g., midazolam/diazepam—know office emergency kit contents)
  5. Cardiovascular collapse: ACLS-based care; lipid emulsion therapy is a modern antidote concept for severe LAST (know existence; hospital-level)
  6. Avoid excess vasopressin/local further LA; follow current emergency algorithms

Differentiate from epinephrine reaction: epi causes brief anxiety, tachycardia, palpitations, ↑ BP soon after injection, usually self-limited; toxicity has sensory prodromes, seizures, progressive CV collapse. Allergy/anaphylaxis has urticaria, bronchospasm, hypotension with distributive shock pattern—epinephrine IM is treatment, opposite of withholding catecholamines for pure LAST.

Rapid review list

  • Infiltration: maxilla + porous bone; blocks when cortex dense or multi-tooth
  • IANB: mandibular foramen landmarks; long buccal separate for molar gingiva
  • PSA: molars ± miss MB root of first molar; pterygoid plexus hematoma
  • Mental = soft tissue; incisive = drive into foramen for pulpal
  • Never hub needles; retrieve visible broken needle; refer if lost
  • Facial palsy after IANB → parotid injection; protect eye; temporary
  • LAST: tinnitus/metallic taste → seizures → coma/CV collapse; O₂, benzos, ACLS, lipids

Section 13.3 covers systemic analgesics, nitrous oxide, oral sedation principles, and ASA physical status for safe case selection.

Test Your Knowledge

Which statement about the posterior superior alveolar (PSA) nerve block is most accurate?

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B
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D
Test Your Knowledge

A patient develops unilateral facial paralysis within minutes after an inferior alveolar nerve block. The most likely mechanism and immediate management emphasis are:

A
B
C
D
Test Your Knowledge

Early systemic local anesthetic toxicity is most likely to present with which constellation?

A
B
C
D
Test Your Knowledge

Which practice best reduces the risk of needle breakage and facilitates retrieval if breakage occurs?

A
B
C
D