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Sample KROK 2 Pharmacy Practice Questions

Try these sample questions to review concepts for the KROK 2 Pharmacy exam. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.

1An analytical chemist in a quality control laboratory performs an identification test for a substance containing a primary aromatic amino group (such as sulfacetamide sodium). According to the State Pharmacopoeia of Ukraine (SPhU), which reaction and resulting observation confirm this functional group?
A.Diazotization with sodium nitrite in hydrochloric acid followed by coupling with alkaline beta-naphthol, producing an intense red-orange azo dye
B.Reaction with ferric chloride solution in neutral medium, forming a deep violet coordinate complex
C.Oxidation with potassium permanganate in sulfuric acid medium, yielding a colorless solution with effervescence
D.Precipitation with barium chloride solution in hydrochloric acid, yielding a heavy white precipitate insoluble in acids
Explanation: Primary aromatic amines undergo diazotization with sodium nitrite ($NaNO_2$) in an acidic medium ($HCl$) at low temperature to form diazonium salts. Subsequent coupling with an alkaline solution of beta-naphthol (2-naphthol) produces an intensely colored red-orange azo dye, which is the pharmacopoeial identification test for sulfonamides, procaine, and related aromatic amines.
2A quality control pharmacist determines the quantitative content of ascorbic acid (Vitamin C) substance in accordance with the State Pharmacopoeia of Ukraine. Which titrimetric method and indicator are officially specified for this assay?
A.Direct iodometry using 0.05 M iodine solution with starch indicator until a persistent blue color appears
B.Acid-base titration with 0.1 M sodium hydroxide using phenolphthalein indicator until a faint pink color
C.Complexometric titration with 0.05 M disodium edetate using eriochrome black T indicator at pH 10
D.Argentometric titration according to Mohr using 0.1 M silver nitrate with potassium chromate indicator
Explanation: Ascorbic acid is a strong reducing agent that is quantitatively and stoichiometrically oxidized to dehydroascorbic acid by iodine. The SPhU specifies direct iodometric titration with 0.05 M iodine standard solution in the presence of starch indicator, where the equivalence point is recognized by the appearance of a persistent pale blue coloration from the first drop of excess iodine.
3During the incoming identity verification of salicylic acid substance, an analyst adds a few drops of neutral ferric chloride solution to an aqueous solution of the substance. Which visual change confirms the presence of the phenolic hydroxyl group?
A.Appearance of an intense violet coloration that persists upon dilution
B.Formation of a canary-yellow crystalline precipitate that dissolves in ammonia
C.Development of an emerald-green color that immediately turns bright scarlet
D.Evolution of dense brown nitrogen dioxide gas fumes
Explanation: Salicylic acid contains a phenolic hydroxyl group adjacent to a carboxylic group. Reaction with ferric chloride ($FeCl_3$) in neutral or weakly acidic aqueous media forms an iron(III) salicylate chelate complex exhibiting an intense violet coloration, which serves as a definitive pharmacopoeial identity test.
4A quality control specialist assays papaverine hydrochloride substance by non-aqueous acid-base titration using 0.1 M perchloric acid ($HClO_4$) in glacial acetic acid. Why must mercuric acetate solution $[Hg(CH_3COO)_2]$ be added to the titration mixture prior to the endpoint determination?
A.To bind the chloride ions as practically undissociated mercuric chloride, thereby releasing equivalent acetate ions for titration
B.To act as a redox catalyst accelerating the proton transfer between perchloric acid and the papaverine base
C.To precipitate insoluble papaverine perchlorate and prevent premature decomposition of the alkaloid nucleus
D.To neutralize trace amounts of water present in glacial acetic acid solvent
Explanation: In glacial acetic acid, chloride ions ($Cl^-$) are too weakly basic to react quantitatively with perchloric acid. Adding mercuric acetate converts ionic chloride into practically unionized, undissociated mercuric chloride $[HgCl_2]$, quantitatively displacing acetate ions ($CH_3COO^-$), which behave as strong bases in acetic acid and are cleanly titrated by perchloric acid.
5A pharmacy director wants to reduce average prescription waiting time from 15 minutes to 10 minutes within three months. Before work begins, she selects the target, estimates the resources needed and chooses actions to achieve it. Which management function is she primarily performing?
A.Control of completed performance
B.Planning of objectives and actions
C.Motivation through employee rewards
D.Organization of reporting relationships
Explanation: Planning establishes the objectives of a pharmaceutical organization and the actions needed to achieve them. Here the director specifies a measurable target, a deadline and an intended course of action before implementation. Control would compare actual results with the target, while organizing would allocate duties and authority and motivation would encourage employees to carry out the work.
6A pharmacy analyst conducts the Vitali-Morin reaction to confirm the identity of atropine sulfate substance. What sequence of reagents is added, and what is the characteristic observation?
A.Evaporation with fuming nitric acid followed by addition of ethanolic potassium hydroxide and acetone, yielding a violet-purple coloration
B.Treatment with Marquis reagent (formaldehyde in sulfuric acid), yielding an immediate crimson-red ring
C.Addition of potassium chlorate and hydrochloric acid followed by ammonia fumes, producing a purple murexide coloration
D.Heating with sulfuric acid and beta-naphthol, producing an intense green fluorescence
Explanation: The Vitali-Morin reaction is specific for tropane alkaloids containing tropic acid esters (atropine, hyoscyamine, scopolamine). Fuming nitric acid nitrates the benzene ring of tropic acid; upon evaporating to dryness and treating the residue with acetone and ethanolic potassium hydroxide, a quinoid resonant chromophore forms, generating an intense violet-purple coloration that gradually fades to brown-red.
7According to the State Pharmacopoeia of Ukraine limit test for chloride impurities, which reagent combination and visual assessment are used to compare the sample against standard chloride solution?
A.Silver nitrate in the presence of dilute nitric acid, comparing opalescence after 5 minutes against a standard opalescence
B.Barium chloride in the presence of dilute hydrochloric acid, comparing turbidity after 10 minutes
C.Ammonium thiocyanate in the presence of ferric alum, comparing red color intensity
D.Sodium cobaltinitrite in acetic acid, comparing crystalline yellow precipitate formation
Explanation: The pharmacopoeial limit test for chlorides relies on the reaction between chloride ions and silver nitrate ($AgNO_3$) in a dilute nitric acid medium: $Ag^+ + Cl^- \rightarrow AgCl\downarrow$. In dilute solutions, silver chloride forms a colloidal opalescence. After standing for 5 minutes protected from direct light, the opalescence of the test solution must not exceed that of a concurrently prepared standard chloride solution.
8A pharmacist measures the refractive index of a compounded aqueous glucose solution using an Abbe refractometer at 20°C. The measured refractive index of the solution is $n = 1.3584$, and the refractive index of purified water is $n_0 = 1.3330$. Given that the refractive index increment factor for glucose is $F = 0.00142$, what is the concentration of glucose in the solution?
A.17.89%
B.12.45%
C.25.40%
D.8.52%
Explanation: Refractometric concentration is calculated using the formula $C = \frac{n - n_0}{F}$, where $n$ is the refractive index of the solution (1.3584), $n_0$ is that of the solvent water (1.3330), and $F$ is the refractive index factor (0.00142). Performing the calculation: $C = \frac{1.3584 - 1.3330}{0.00142} = \frac{0.0254}{0.00142} \approx 17.89\%$.
9An analytical chemist determines the purity and quantitative content of isoniazid (isonicotinic acid hydrazide) substance by bromatometric titration in hydrochloric acid medium. What serves as the indicator, and how is the equivalence point signaled?
A.Methyl orange (or methyl red) indicator, which is irreversibly destroyed and decolorized by the first trace of free bromine at the endpoint
B.Starch indicator, which turns deep indigo blue due to the formation of an iodine-starch clathrate complex
C.Phenolphthalein indicator, which turns from colorless to pink upon the appearance of excess hydroxide ions
D.Diphenylamine indicator, which oxidizes from colorless to deep violet in the presence of excess bromide
Explanation: In the bromatometric assay of isoniazid, potassium bromate in the presence of potassium bromide generates bromine in situ in an acidic medium: $BrO_3^- + 5Br^- + 6H^+ \rightarrow 3Br_2 + 3H_2O$. Bromine quantitatively oxidizes the hydrazide moiety of isoniazid to isonicotinic acid, nitrogen gas, and water. An azo indicator such as methyl orange or methyl red is present; the first drop of excess unreacted bromine oxidatively brominates and bleaches the indicator dye, producing an irreversible disappearance of color at the endpoint.
10A quality control pharmacist verifies the identity of phenobarbital substance. Which reaction confirms the cyclic ureide/barbiturate structure, and which visual result is observed?
A.Reaction with cobalt nitrate and calcium chloride in the presence of sodium hydroxide (Parri reaction), producing a violet-blue coloration
B.Reaction with sodium nitroprusside in alkaline medium, producing an immediate blood-red coloration fading to yellow
C.Reaction with resorcinol in concentrated sulfuric acid, producing an intense red-orange fluorescence under ultraviolet light
D.Reaction with ninhydrin in neutral buffer, producing Ruhemann's purple complex
Explanation: Barbiturates are cyclic ureides containing an imide moiety capable of keto-enol tautomerism in alkaline media. In the Parri (Zwikker) reaction, phenobarbital reacts with cobalt(II) salts in the presence of an amine base or alkali, forming a coordination complex of cobalt with the ionized imide groups that exhibits a characteristic violet-blue coloration.

About the KROK 2 Pharmacy Exam

Independent practice questions for KROK 2 Pharmacy, the professional licensing examination for graduating pharmacy students administered by the Testing Center of the Ministry of Health of Ukraine.

Exam sponsor: ДНТ «Центр якості освіти МОЗ» (Testing Center of the Ministry of Health of Ukraine). The requirements and fees below concern the certification or admission exam, separate from our free practice resources.

Assessment

Stage 2 Unified State Qualification Examination (ЄДКІ) test of 150 single-best-answer MCQs covering medicine chemistry, rational use and pharmaceutical care, medicinal plants, pharmacy organization and accounting, pharmaceutical management and marketing, and medicine technology.

Time Limit

150 min (180 min for foreign students)

Passing Score

64.0%

Exam / Certification Fees

Ordinary exam costs are covered by state funding for state-funded students or included in tuition for fee-paying students. Universities arrange payment to the Testing Center. During martial law, up to two retakes are allowed at the learner's expense. Overseas certification centres set their own sitting charges, payable by the learner. Confirm the applicable amount with your university and test centre.

Exam sponsor website

Fees, eligibility, and exam policies can change. Confirm them with the exam sponsor before applying or paying.

Our practice resources: topics covered

We aim to reflect publicly available exam outlines and topic information in our study resources. Coverage, format, and difficulty may differ from the actual exam, and we cannot guarantee that every detail is accurate or current. Confirm exam requirements, fees, and policies with the official exam sponsor.

20%

Chemical Foundations of Medicine Quality and Rational Use

Drug structure and properties, identification, impurity testing, quantitative analysis, and chemical stability.

20%

Rational Use of Medicines and Pharmaceutical Care

Rational pharmacotherapy, patient counseling, drug interactions, adverse reactions, and referral decisions.

14%

Medicinal Plant Materials and Medicines Derived from Them

Identification, constituents, quality control, processing, and uses of medicinal plant materials.

14%

Pharmacy Organization, Economics and Accounting

Pharmacy operations, stock control, dispensing, compounding quality control, accounting, taxation, and financial analysis.

14%

Management of Pharmaceutical Organizations in Market Conditions

Pharmaceutical management, entrepreneurship, management processes, and pharmaceutical marketing.

18%

Technology of Medicines

Pharmacy compounding and industrial manufacture of dosage forms, including sterile preparations.

Preparing for the KROK 2 Pharmacy Exam

What You Need to Know

  • Passing score: 64.0%
  • Assessment: Stage 2 Unified State Qualification Examination (ЄДКІ) test of 150 single-best-answer MCQs covering medicine chemistry, rational use and pharmaceutical care, medicinal plants, pharmacy organization and accounting, pharmaceutical management and marketing, and medicine technology.
  • Time limit: 150 min (180 min for foreign students)
  • Exam / certification fees: Ordinary exam costs are covered by state funding for state-funded students or included in tuition for fee-paying students. Universities arrange payment to the Testing Center. During martial law, up to two retakes are allowed at the learner's expense. Overseas certification centres set their own sitting charges, payable by the learner. Confirm the applicable amount with your university and test centre. Official sources

Using Our Practice Resources

  • Work through all 100 available questions
  • Review every answer and explanation
  • Track weak areas and revisit them
  • Use our AI tutor for tough concepts

KROK 2 Pharmacy: Suggested Study Strategy

1Review functional group reactions and quantitative assay equations according to the State Pharmacopoeia of Ukraine (SPhU).
2Master extemporaneous compounding calculations, including triturations, displacement values, and isotonic equivalents.
3Memorize prescription dispensing rules under MOH Order No. 360 and e-prescription requirements in the eHealth system.
4Study microscopic diagnostic features and chemical identification tests for major medicinal plant families.
5Practice OTC patient counseling protocols, identifying threatening symptoms that mandate immediate physician referral.

Frequently Asked Questions

What is KROK 2 Pharmacy in Ukraine?

KROK 2 Pharmacy is the mandatory state licensing integrated test taken by graduating Master of Pharmacy students (specialty 226 'Pharmacy, Industrial Pharmacy') as part of Stage 2 of the Unified State Qualification Examination (ЄДКІ) under the Ministry of Health of Ukraine.

What is the passing score for KROK 2 Pharmacy?

The passing threshold established by the Ministry of Health of Ukraine (Order No. 1898) is 64.0% of correct answers.

How many questions are on the official KROK 2 Pharmacy examination?

The official exam contains 150 single-best-answer MCQs, with 150 minutes for Ukrainian citizens and 180 minutes for foreign citizens and stateless candidates.

What subjects are tested on KROK 2 Pharmacy?

The 2026 outline has six domains: chemical foundations of medicine quality and rational use (20%); rational use and pharmaceutical care (20%); medicinal plant materials and derived medicines (14%); pharmacy organization, economics and accounting (14%); pharmaceutical management and marketing (14%); and technology of medicines (18%).

Is this practice bank an official test booklet?

No. This is an independent English-language MCQ study adaptation, not an official translation or format simulation. It does not replace preparation for separate practical or written qualification assessments.