Free Practice Questions for Pharmacist Pre-Registration Exam

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Sample Pharmacist Pre-Registration Exam Practice Questions

Try these sample questions to review concepts for the Pharmacist Pre-Registration Exam exam. Each question includes a detailed explanation. Start the interactive quiz above for the full 20+ question experience with AI tutoring.

1Which tablet excipient is primarily used as a superdisintegrant?

A.Croscarmellose sodium

B.Magnesium stearate

C.Ethylcellulose

D.Colloidal silicon dioxide

Explanation: Croscarmellose sodium promotes tablet breakup through water uptake and swelling. Its formulation role differs from lubrication, sustained-release coating and flow improvement.

2Which properties define BCS Class II drug substances?

A.High solubility and high permeability

B.Low solubility and high permeability

C.High solubility and low permeability

D.Low solubility and low permeability

Explanation: The Biopharmaceutics Classification System places low-solubility, high-permeability substances in Class II. Dissolution can therefore be an important limitation on absorption.

3A tablet assay is 88.5% of label claim against a specified range of 95.0–105.0%. What is the appropriate initial quality-control response?

A.Average the result with repeated tests until the mean passes

B.Blend the batch with stronger tablets

C.Start a documented investigation, preserving the original result and checking the laboratory work

D.Discard the original worksheet and repeat the assay

Explanation: An out-of-specification result requires investigation, including review for possible laboratory error. Retesting needs scientific justification and must not erase an unexplained failure.

4How many milligrams per millilitre are present in a 2% w/v lidocaine solution?

A.0.2 mg/mL

B.2 mg/mL

C.200 mg/mL

D.20 mg/mL

Explanation: Two percent w/v means 2 g in 100 mL of final solution. Converting gives 2,000 mg ÷ 100 mL = 20 mg/mL.

5In a simplified intravenous loading-dose calculation, a 70 kg patient has a drug volume of distribution of 0.6 L/kg and target concentration of 15 mg/L. Using dose = target concentration × total volume of distribution, what dose is calculated?

A.630 mg

B.420 mg

C.1,050 mg

D.350 mg

Explanation: The total volume of distribution is 70 × 0.6 = 42 L. Multiplying 42 L by 15 mg/L gives 630 mg under the stated model.

6A linear pharmacokinetic model uses oral maintenance dose = average target concentration × clearance × dosing interval ÷ bioavailability. With 20 mg/L, 3 L/hour, 8 hours and bioavailability 0.75, what dose is calculated?

A.480 mg every 8 hours

B.640 mg every 8 hours

C.360 mg every 8 hours

D.240 mg every 8 hours

Explanation: The systemically available amount needed per interval is 20 × 3 × 8 = 480 mg. Dividing by 0.75 gives an oral dose of 640 mg under the stated assumptions.

7After a 500 mg IV bolus, concentrations at 2 and 6 hours are 16 and 4 mg/L. Assume a one-compartment first-order model: k = ln(C1/C2)/(t2−t1), C0 = C1 × exp(k × t1), and Vd = dose/C0. Which pair is correct?

A.k = 0.693/hour; Vd = 10 L

B.k = 0.173/hour; Vd = 50 L

C.k = 0.347/hour; Vd = 15.6 L

D.k = 0.086/hour; Vd = 31.2 L

Explanation: The elimination constant is ln(16/4) ÷ 4 = 0.3466/hour. Extrapolation gives C0 = 32 mg/L, so Vd = 500 ÷ 32 = 15.625 L.

8In Tanzania's HIV treatment terminology, which medicines make up TLD?

A.Tenofovir, lopinavir and darunavir

B.Tenofovir, lamivudine and darunavir

C.Tenofovir, lopinavir and dolutegravir

D.Tenofovir disoproxil fumarate, lamivudine and dolutegravir

Explanation: TLD denotes tenofovir disoproxil fumarate, lamivudine and dolutegravir. Recognizing the components helps identify interactions, contraindications and duplication during medication review.

9Which authority receives Tanzania's healthcare-professional Yellow Form reports of suspected adverse drug reactions?

A.Tanzania Medicines and Medical Devices Authority

B.National Health Insurance Fund

C.Tanzania Nursing and Midwifery Council

D.Tanzania Revenue Authority

Explanation: TMDA operates the national medicine-safety reporting system. Reporting a suspected reaction supports pharmacovigilance and does not require the reporter to prove causality first.

10What is the specific antidote used for a clinically significant paracetamol overdose?

A.Naloxone

B.N-acetylcysteine

C.Flumazenil

D.Atropine

Explanation: N-acetylcysteine replenishes glutathione and helps limit paracetamol-related liver injury. Suspected overdose requires urgent assessment and timely treatment using the appropriate poisoning protocol.

About the Pharmacist Pre-Registration Exam Exam

The Pharmacy Council conducts this examination for eligible intern pharmacists seeking registration in Mainland Tanzania. Its applied scope includes formulations, pharmacokinetics, clinical pharmacy, supply management and pharmacy law. This independent collection is focused practice across the three papers, not exhaustive preparation for every listed topic.

Exam sponsor: Pharmacy Council. The requirements and fees below concern the certification or admission exam, separate from our free practice resources.

Assessment

Three written papers: applied pharmaceutical compounding/calculations/formulations; applied hospital and community practice; and laws/regulations/ethics/conduct. Sections include MCQs, true/false or matching, and short/long answers. Internship and its logbook are separate professional-training requirements; a separate mandatory examination oral, practical or case-study submission was not established by the cited examination guidelines.

Time Limit

Up to three hours per paper under the 2019 guidelines; consult the current sitting timetable.

Passing Score

60% in every paper; passing an aggregate alone does not satisfy the three-paper requirement.

Exam / Certification Fees

TZS 160,000 for new applicants; TZS 50,000 per resit paper (April 2026 notice).

Exam sponsor website

Fees, eligibility, and exam policies can change. Confirm them with the exam sponsor before applying or paying.

Official sources

Council examination contents, current linked 2025 document · Source checked 2026-10-23
Council examination guidelines, 2019 · Source checked 2026-10-23
Council examination notice, 10 April 2026 · Source checked 2026-10-23
Current application requirements · Source checked 2026-10-23
Council regulations and guidelines, including 2024 ethics and 2026 CPD guidance · Source checked 2026-10-23
TMDA current regulatory publications · Source checked 2026-10-23Check publication status; draft texts are not enacted rules.
Council examination notice, 24 September 2026 · Source checked 2026-10-23
FDA guidance on investigating out-of-specification test results · Source checked 2026-10-23Technical quality-control reference.
WHO Shake Test procedure for eligible adsorbed vaccines · Source checked 2026-10-23
TMDA promotion and advertisement guidance, 2015 · Source checked 2026-10-23
Prescription Handling and Control Regulations, 2020 · Source checked 2026-10-23

Our practice resources: topics covered

We aim to reflect publicly available exam outlines and topic information in our study resources. Coverage, format, and difficulty may differ from the actual exam, and we cannot guarantee that every detail is accurate or current. Confirm exam requirements, fees, and policies with the official exam sponsor.

Separate paper

Paper I: Applied Compounding, Calculations and Formulations

Formulation science, quality, GMP and pharmaceutical calculations.

Separate paper

Paper II: Applied Hospital and Community Practice

Patient care, interactions, pharmacovigilance, stewardship and supply management.

Separate paper

Paper III: Laws, Regulations, Ethics and Conduct

Professional obligations and current pharmacy and medicine-control requirements.

Preparing for the Pharmacist Pre-Registration Exam Exam

What You Need to Know

Passing score: 60% in every paper; passing an aggregate alone does not satisfy the three-paper requirement.
Assessment: Three written papers: applied pharmaceutical compounding/calculations/formulations; applied hospital and community practice; and laws/regulations/ethics/conduct. Sections include MCQs, true/false or matching, and short/long answers. Internship and its logbook are separate professional-training requirements; a separate mandatory examination oral, practical or case-study submission was not established by the cited examination guidelines.
Time limit: Up to three hours per paper under the 2019 guidelines; consult the current sitting timetable.
Exam / certification fees: TZS 160,000 for new applicants; TZS 50,000 per resit paper (April 2026 notice). Official sources

Using Our Practice Resources

Work through all 20 available questions
Review every answer and explanation
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Pharmacist Pre-Registration Exam: Suggested Study Strategy

1Use the current contents for all three papers and practice written explanations as well as calculations.

2Check current Tanzanian laws, the 2024 ethics code and subsequent TMDA notices.

3Apply product-specific labeling and patient-specific factors during clinical medicine review.

Frequently Asked Questions

How much internship is required?

The Council FAQ and 2019 guidelines refer to at least nine months for examination eligibility. The April 2026 notice requests evidence of internship completion. Follow the current sitting's requirements and confirm eligibility with the Council; passing the examination does not replace completion of required training and logbook obligations.

When are the examinations held?

Dates are announced by the Council. Do not treat the 2019 February/June/October pattern as guaranteed: 2026 notices document March and July sittings.

What language can candidates use?

An explicit examination-language policy was not verified. Check permitted response languages with the Council. English application requirements and Swahili announcements do not by themselves establish assessment-language availability.