Free Practice Questions for LF UK Medicine Entrance Exam

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Key Facts: LF UK Medicine Entrance Exam Exam

The LF UK natural sciences test has 100 biology and 100 chemistry questions.

The natural sciences test lasts 3 hours and is held only in person.

Each question has four options, of which 0 to 4 may be correct.

Each option is scored +1 if judged correctly and -1 if judged wrongly, for a maximum of 800 points.

The overall result weights biology 42%, chemistry 42% and the Scio VŠP test 16%.

Up to 40 bonus points are available for competition results or a C1/C2 English certificate.

For 2026/2027 entry the fee was 99 EUR per study programme, including one Scio VŠP test.

The planned intake for 2026/2027 was 375 students in general medicine and 32 in dentistry (Slovak-language programmes).

The test content does not exceed the secondary-school biology and chemistry curriculum.

The LF UK natural sciences test has 100 biology and 100 chemistry questions in 3 hours, each with 0–4 correct options scored +1/−1 per option (maximum 800 points); it counts 84% of the admission result alongside the Scio VŠP test (16%).

Sample LF UK Medicine Entrance Exam Practice Questions

Try these sample questions to review concepts for the LF UK Medicine Entrance Exam exam. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.

1Which organelle is primarily responsible for the synthesis of ribosomal RNA (rRNA) and the assembly of ribosomal subunits in eukaryotic cells?

A.Nucleolus

B.Rough endoplasmic reticulum

C.Golgi apparatus

D.Centrosome

Explanation: The nucleolus is a non-membrane-bound dense subnuclear structure where rRNA transcription and initial ribosome subunit assembly occur. Completed subunits are subsequently exported through nuclear pore complexes into the cytosol.

2How many chromatids does a human diploid somatic cell contain during the G2 phase of the cell cycle?

A.23

B.46

C.92

D.184

Explanation: A human somatic cell has 46 chromosomes (2n = 46). During the S phase each chromosome is replicated, so in G2 every chromosome consists of two sister chromatids joined at the centromere: 46 × 2 = 92 chromatids. The chromosome number stays 46 until the sister chromatids separate in anaphase.

3Which component of the eukaryotic plasma membrane is primarily responsible for maintaining fluidity across fluctuating physiological temperatures?

A.Sphingomyelin head groups

B.Peripheral proteins

C.Glycocalyx oligosaccharides

D.Cholesterol

Explanation: Cholesterol acts as a bidirectional membrane fluidity buffer. At high temperatures, its rigid steroid ring restricts excessive phospholipid fatty acyl chain mobility, while at low temperatures it prevents dense chain packing and crystallization.

4Which mechanism describes the active transport of glucose across the apical membrane of human intestinal enterocytes against its concentration gradient?

A.Primary active transport via ATP-binding cassette transporter

B.Secondary active transport via sodium-glucose symport

C.Facilitated diffusion through GLUT2 transporter

D.Simple passive diffusion across lipid bilayer

Explanation: The sodium-glucose cotransporter 1 (SGLT1) couples the downhill influx of two sodium ions down their electrochemical gradient to the uphill transport of one glucose molecule into the enterocyte. The sodium gradient is continuously maintained by the basolateral Na+/K+ ATPase pump.

5What is the primary role of the lysosome in eukaryotic cell biology?

A.Oxidation of very-long-chain fatty acids producing hydrogen peroxide

B.Post-translational O-linked glycosylation of secretory proteins

C.Enzymatic degradation of macromolecules via acid hydrolases

D.Synthesis of steroid hormones from cholesterol esters

Explanation: Lysosomes are acidic membrane-bound organelles maintaining an internal pH of approximately 4.5 to 5.0 via vacuolar H+-ATPases. They contain over 50 acid hydrolases that degrade endocytosed material, damaged organelles, and cellular debris.

6In which substage of prophase I of meiosis does crossing-over between non-sister chromatids of homologous chromosomes take place?

A.Leptotene

B.Zygotene

C.Pachytene

D.Diplotene

Explanation: Crossing-over occurs during pachytene once synapsis is fully established by the synaptonemal complex. Recombination nodules mediate physical genetic exchange between non-sister chromatids.

7Which cytoskeletal filament is composed of actin subunits and generates contractile forces in non-muscle animal cells?

A.Microtubules

B.Intermediate filaments

C.Neurofilaments

D.Microfilaments

Explanation: Microfilaments (actin filaments) are polar, two-stranded helical polymers of globular G-actin subunits that form F-actin. Interacting with myosin motor proteins, they drive cytokinesis furrowing, amoeboid motility, and cortical tension.

8What is the primary function of the rough endoplasmic reticulum in mammalian cells?

A.Oxidative phosphorylation and generation of ATP

B.Synthesis and initial folding of secretory and transmembrane proteins

C.Lipid catabolism and detoxification of lipid-soluble xenobiotics

D.Degradation of unneeded cytosolic proteins via polyubiquitination

Explanation: The rough endoplasmic reticulum possesses surface-bound 80S ribosomes that translocate nascent polypeptide chains into the lumen. These proteins undergo signal peptide cleavage, chaperone-assisted folding, and N-linked core glycosylation.

9Which cellular junction forms an impermeable belt around epithelial cells, preventing the paracellular transit of solutes across tissue barriers?

A.Adherens junctions (zonula adherens)

B.Desmosomes (macula adherens)

C.Gap junctions (nexus)

D.Tight junctions (zonula occludens)

Explanation: Tight junctions (zonula occludens) consist of claudin and occludin transmembrane proteins that fuse adjacent cell membranes near the apical pole. They establish a selective paracellular barrier and preserve epithelial cell polarity.

10During which phase of mitosis do sister chromatids synchronously separate and move toward opposite spindle poles?

A.Prophase

B.Metaphase

C.Anaphase

D.Telophase

Explanation: Anaphase begins when the anaphase-promoting complex triggers the proteolytic cleavage of cohesin complexes by separase. Kinetochore microtubules depolymerize, drawing sister chromatids toward opposite centrosomal poles.

About the LF UK Medicine Entrance Exam Exam

Independent study practice for the natural sciences admission test (test prírodných vied) of the Faculty of Medicine of Comenius University in Bratislava (LF UK), used for the Slovak-language programmes general medicine (MUDr., 6 years) and dentistry (MDDr., 5 years). For 2026/2027 entry the admission examination combined the Scio general study aptitude test (VŠP, 16%) with the in-person natural sciences test (84%: biology 42%, chemistry 42%). The natural sciences test has 100 biology and 100 chemistry questions in 3 hours, its content does not exceed the secondary-school curriculum, and each question has four options of which 0 to 4 may be correct, scored +1 or -1 per option for a maximum of 800 points. Up to 40 bonus points are awarded for olympiad and competition results or a C1/C2 English certificate. The 2026 test dates were 9 May (general medicine; Bratislava, Nitra, Žilina, Košice and Prešov) and 10 May (dentistry), and the fee was 99 EUR. Up to 30% of general-medicine places can go to top students admitted without the examination. The 100 practice questions are split evenly between biology and chemistry. This bank is an English-language, four-option study adaptation with one correct answer per question; it does not reproduce the official multiple-true scoring.

Exam sponsor: Lekárska fakulta Univerzity Komenského v Bratislave (LF UK). The requirements and fees below concern the certification or admission exam, separate from our free practice resources.

Assessment

Part 1: Scio general study aptitude test (VŠP), online or in person, repeatable, weighted 16%. Part 2: natural sciences test, in person only, 100 biology + 100 chemistry questions in 3 hours, maximum 800 points, weighted 84% (biology 42%, chemistry 42%). Up to 40 bonus points are available for olympiad and competition results or a C1/C2 English certificate.

Time Limit

3 hours (natural sciences test)

Passing Score

No fixed pass mark; competitive ranking by the weighted combination of the natural sciences test (84%) and the Scio VŠP test (16%), plus up to 40 bonus points.

Exam / Certification Fees

99 EUR per study programme (2026/2027 entry), including one Scio VŠP test

Exam sponsor website

Fees, eligibility, and exam policies can change. Confirm them with the exam sponsor before applying or paying.

Official sources

Our practice resources: topics covered

We aim to reflect publicly available exam outlines and topic information in our study resources. Coverage, format, and difficulty may differ from the actual exam, and we cannot guarantee that every detail is accurate or current. Confirm exam requirements, fees, and policies with the official exam sponsor.

Biology counts 42% of the overall result; 34 of 100 practice questions

Cytológia a biológia človeka (Cytology and Human Biology)

Cell structure and organelles, membranes and transport, the cell cycle and cell division, and human organ systems, regulation, immunity and reproduction.

Biology counts 42% of the overall result; 16 of 100 practice questions

Genetika človeka a mikrobiológia (Human Genetics and Microbiology)

Molecular genetics, Mendelian and sex-linked inheritance, chromosomal disorders, population genetics, bacteria and viruses, and immunization.

Chemistry counts 42% of the overall result; 26 of 100 practice questions

Všeobecná a anorganická chémia (General and Inorganic Chemistry)

Atomic structure and the periodic table, chemical bonding, thermodynamics and kinetics, equilibrium, acids, bases and buffers, redox reactions, solutions and inorganic compounds.

Chemistry counts 42% of the overall result; 24 of 100 practice questions

Organická chémia a biochémia (Organic Chemistry and Biochemistry)

Hydrocarbons and their derivatives, isomerism and reaction mechanisms, lipids, saccharides, amino acids and proteins, enzymes, and metabolic pathways.

Preparing for the LF UK Medicine Entrance Exam Exam

What You Need to Know

Passing score: No fixed pass mark; competitive ranking by the weighted combination of the natural sciences test (84%) and the Scio VŠP test (16%), plus up to 40 bonus points.
Assessment: Part 1: Scio general study aptitude test (VŠP), online or in person, repeatable, weighted 16%. Part 2: natural sciences test, in person only, 100 biology + 100 chemistry questions in 3 hours, maximum 800 points, weighted 84% (biology 42%, chemistry 42%). Up to 40 bonus points are available for olympiad and competition results or a C1/C2 English certificate.
Time limit: 3 hours (natural sciences test)
Exam / certification fees: 99 EUR per study programme (2026/2027 entry), including one Scio VŠP test Official sources

Using Our Practice Resources

Work through all 100 available questions
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LF UK Medicine Entrance Exam: Suggested Study Strategy

1Practise judging every option as true or false on its own, because the real test can have anywhere from zero to four correct answers per question.

2Remember that a wrongly judged option costs a point, so think twice before marking statements you are unsure about.

3Work through the faculty's published question books in biology and chemistry, which are the standard preparation material.

4Give chemistry the same attention as biology: each counts 42% of the overall result.

5Prepare for the Scio VŠP test as well; it can be repeated, and the best result is sent to the faculty.

Frequently Asked Questions

What does the LF UK admission examination consist of?

For 2026/2027 entry it had two parts: the Scio general study aptitude test (VŠP), taken online or in person and repeatable, and the natural sciences test, taken only in person, with 100 biology and 100 chemistry questions in 3 hours. The examination is valid only if both tests are taken, and the result for one study programme cannot be used for the other.

How is the natural sciences test scored?

Each question has four options, and any number of them, from none to all four, may be correct. Every option you mark or leave unmarked correctly earns 1 point, and every option judged wrongly loses 1 point, so each question is worth from -4 to +4 points and the maximum is 800. In the overall result the natural sciences test counts 84% (biology 42%, chemistry 42%) and the VŠP test 16%.

Are bonus points or admission without the examination possible?

Up to 40 bonus points are awarded for results in secondary-school olympiads and competitions (40 for an international round, 30 for a top-10 national place, 25 for a top-3 regional place) or a C1/C2 English certificate (25). For general medicine only, up to 30% of the planned places can go to applicants admitted without the examination, who must meet strict conditions including an average of 1.100 or better.

Is this practice bank an official LF UK test?

No. This is independent practice by OpenExamPrep: an English-language, four-option study adaptation of secondary-school biology and chemistry topics with one correct answer per question. It is not an official test or translation, and it does not reproduce the official format in which each option is judged true or false independently.