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100+ Free PPB Pharmacist Pre-registration Exam Practice Questions

Prepare for the Pharmacy and Poisons Board Pharmacist Pre-registration Examination (Stage I and Stage II) exam with instant access — no signup required.

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Sample PPB Pharmacist Pre-registration Exam Practice Questions

Try these sample questions to test your PPB Pharmacist Pre-registration Exam exam readiness. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.

1A candidate reviews lipid pharmacology for the PPB pharmacist pre-registration exam. Which enzyme is the rate-limiting target inhibited by statins?
A.HMG-CoA reductase
B.Squalene epoxidase
C.Acetyl-CoA carboxylase
D.Cholesterol 7-alpha-hydroxylase
Explanation: HMG-CoA reductase catalyzes the rate-limiting step in cholesterol synthesis. Statins competitively inhibit this enzyme, lowering hepatic cholesterol synthesis and increasing LDL receptor expression.
2A patient with known G6PD deficiency is prescribed an antimalarial. Which medicine is most likely to precipitate oxidative haemolysis?
A.Amoxicillin
B.Primaquine
C.Metformin
D.Omeprazole
Explanation: Primaquine is an oxidant drug that can trigger haemolysis in G6PD deficiency. Pharmacists should identify this risk before dispensing antimalarial therapy that includes primaquine or related oxidant medicines.
3A medicine undergoes extensive first-pass metabolism. What is the most likely effect after oral administration?
A.No change in plasma concentration
B.Increased oral bioavailability
C.Reduced amount reaching systemic circulation
D.Immediate renal excretion before absorption
Explanation: First-pass metabolism in the gut wall or liver reduces the fraction of an oral dose that reaches systemic circulation unchanged. This can require higher oral doses or alternative routes for some medicines.
4Beta-lactam antibiotics primarily kill susceptible bacteria by interfering with which process?
A.Bacterial DNA gyrase inhibition
B.Folate synthesis at dihydropteroate synthase
C.Protein synthesis at the 50S ribosome
D.Bacterial cell-wall peptidoglycan cross-linking
Explanation: Beta-lactams bind penicillin-binding proteins and inhibit peptidoglycan cross-linking, weakening the bacterial cell wall. This mechanism underpins their selective toxicity against actively dividing bacteria.
5Which finding is most consistent with muscarinic cholinergic stimulation?
A.Salivation, bronchoconstriction and bradycardia
B.Mydriasis and constipation
C.Dry mouth and urinary retention
D.Bronchodilation and tachycardia
Explanation: Muscarinic stimulation produces parasympathetic effects such as salivation, lacrimation, bronchoconstriction, bradycardia, miosis, increased gut motility, and urination.
6Alkalinising the urine can increase renal elimination of which type of drug?
A.Highly protein-bound monoclonal antibodies
B.Weak acids
C.Neutral lipids
D.Strong bases only
Explanation: Urine alkalinisation ionises weak acids, reducing tubular reabsorption and increasing excretion. This principle is used in selected toxicology situations under appropriate medical supervision.
7Type 1 diabetes mellitus is primarily caused by which pathophysiologic process?
A.Overproduction of incretin hormones
B.Insulin resistance from adiposity alone
C.Autoimmune destruction of pancreatic beta cells
D.Excess glucagon receptor blockade
Explanation: Type 1 diabetes is caused by autoimmune beta-cell destruction, leading to absolute insulin deficiency. Pharmacists should distinguish this from insulin resistance-dominant type 2 diabetes.
8Non-steroidal anti-inflammatory drugs reduce pain and inflammation mainly by inhibiting formation of which mediators?
A.Insulin-like growth factors
B.Thyroid hormones
C.Catecholamines
D.Prostaglandins
Explanation: NSAIDs inhibit cyclo-oxygenase enzymes and reduce prostaglandin synthesis. This explains their analgesic and anti-inflammatory effects and also many adverse effects such as gastric irritation and renal risk.
9Which immunoglobulin is most important for mucosal immunity in secretions such as saliva, tears and breast milk?
A.IgA
B.IgE
C.IgG
D.IgM
Explanation: Secretory IgA is the dominant immunoglobulin at mucosal surfaces and in secretions. It helps neutralise pathogens at entry sites before systemic infection develops.
10Rifampicin can reduce the effect of many medicines because it has which property?
A.It strongly inhibits gastric emptying
B.It induces hepatic drug-metabolising enzymes
C.It chelates calcium in the gut
D.It blocks renal tubular secretion of penicillins
Explanation: Rifampicin is a potent enzyme inducer and can reduce exposure to many medicines, including some antiretrovirals, anticoagulants and hormonal contraceptives. Interaction screening is essential.

About the PPB Pharmacist Pre-registration Exam Exam

Kenya's pharmacist registration route is administered by the Pharmacy and Poisons Board (PPB), the statutory drug regulatory authority under the Pharmacy and Poisons Act, Cap 244. The relevant public exam route is the PPB Pre-registration Examination for pharmacists, organized as Stage I and Stage II. Public PPB pages confirm eligibility criteria for pre-registration examination, online application through the PPB online services portal, online delivery at designated centres, paper duration, current exam-window notices, mandatory rehearsal, mock exam logistics, and resit limits.

Assessment

The pharmacist route is publicly described as PPB Pre-registration Exams, Stage I and Stage II. Current PPB exam schedules list Paper I and Paper II for Stage I and Stage II, administered online at designated examination centres. The PPB registration page describes evaluation and assessment of locally and foreign-trained pharmacists for registration to practise in Kenya.

Time Limit

Each paper is currently listed as 2 hours 30 minutes. Candidates use the PPB online examinations portal and Safe Exam Browser at designated centres; PPB also publishes mock and mandatory rehearsal logistics.

Passing Score

Not published in the current PPB June 2026 public exam notice. A legacy PPB professional-exam manual for pharmaceutical technologists states a 50% aggregate pass mark, but a current pharmacist-specific public cut score was not found.

Exam Fee

Not published in the current public PPB exam notice. The PPB exams page says the online application generates an invoice and prompts payment after relevant documents are uploaded. (Pharmacy and Poisons Board (PPB), Kenya)

PPB Pharmacist Pre-registration Exam Exam Content Outline

12 questions

basic-medical-chemical-sciences

Biomedical and chemical foundations: microbiology, immunology, physiology, medicinal chemistry, pharmacology principles, metabolism, and antimicrobial resistance.

14 questions

pharmaceutics-and-physical-pharmacy

Dosage-form design, excipients, suspensions, emulsions, sterile preparation concepts, stability, modified release, cold-chain handling, and compatibility.

12 questions

pharmaceutical-calculations-and-biopharmaceutics

Dose, concentration, dilution, ratio-strength, infusion-rate, reconstitution, bioavailability, and bioequivalence calculations and concepts.

14 questions

pharmacology-and-toxicology

Drug mechanisms, adverse effects, contraindications, interactions, antidotes, poisoning, and therapeutic monitoring.

20 questions

clinical-pharmacotherapy-and-patient-care

Applied care for common conditions and Kenya-relevant public-health burdens including malaria, TB, HIV, diarrhoeal illness, hypertension, diabetes, asthma, pregnancy, and emergencies.

12 questions

pharmacy-practice-dispensing-and-counselling

Prescription screening, labelling, counselling, adherence, confidentiality, referral, cold chain, stock rotation, and error management.

10 questions

kenya-pharmacy-law-ethics-and-regulation

PPB mandate, Cap 244, registration, practice licences, premises, title protection, poisons rules, online applications, and resits.

6 questions

supply-chain-quality-and-public-health-pharmacy

Product registration, pharmacovigilance, substandard medicine reporting, antimicrobial stewardship, essential medicines, and representative conduct.

How to Pass the PPB Pharmacist Pre-registration Exam Exam

What You Need to Know

  • Passing score: Not published in the current PPB June 2026 public exam notice. A legacy PPB professional-exam manual for pharmaceutical technologists states a 50% aggregate pass mark, but a current pharmacist-specific public cut score was not found.
  • Assessment: The pharmacist route is publicly described as PPB Pre-registration Exams, Stage I and Stage II. Current PPB exam schedules list Paper I and Paper II for Stage I and Stage II, administered online at designated examination centres. The PPB registration page describes evaluation and assessment of locally and foreign-trained pharmacists for registration to practise in Kenya.
  • Time limit: Each paper is currently listed as 2 hours 30 minutes. Candidates use the PPB online examinations portal and Safe Exam Browser at designated centres; PPB also publishes mock and mandatory rehearsal logistics.
  • Exam fee: Not published in the current public PPB exam notice. The PPB exams page says the online application generates an invoice and prompts payment after relevant documents are uploaded.

Keys to Passing

  • Work through all 100 available questions
  • Review every answer and explanation
  • Track weak areas and revisit them
  • Use our AI tutor for tough concepts

PPB Pharmacist Pre-registration Exam Study Tips from Top Performers

1Study Stage I and Stage II as one registration pathway: foundations first, then applied clinical pharmacy, pharmacy practice, Kenya law, and ethics.
2Anchor law revision in Kenyan sources: Pharmacy and Poisons Act Cap 244, the Pharmacy and Poisons Rules, PPB licensing/practice pages, and PPB public notices.
3Prioritize Kenya-specific public-health practice: malaria ACT use and referral, TB adherence and rifampicin interactions, HIV ART counselling, pharmacovigilance through PPB systems, antimicrobial stewardship, and safe handling of registered health products.

Frequently Asked Questions

What is the official name of this Kenya pharmacy exam route?

The current public source label should be normalized to the Pharmacy and Poisons Board (PPB) Pharmacist Pre-registration Examination, Stage I and Stage II. PPB is the official administrator; 'PCK' is not the official Kenyan pharmacy regulator name for this route.

Who is eligible to undertake the pre-registration exams?

PPB's registration page lists criteria including basic O-level education with C+ or equivalent, a minimum four-year pharmacy degree from a college or university recognized by the country's pharmacy regulator, a B.Pharm curriculum acceptable to PPB, command of English and basic Kiswahili, and registrability with the pharmacy regulator in the country offering the degree.

What logistics are public for the June 2026 exam series?

PPB's June 2026 notice states that Pre-registration Exams (Stage I and II) and Enrolment Exams (Level I and II) run June 8-12, 2026, are online at designated centres, require application through the PPB online services portal by May 22, 2026, and include mandatory rehearsal and mock-exam preparation.

How many questions, how much time, and what pass mark?

The public PPB exams page states that each paper lasts 2 hours 30 minutes. Current public PPB pharmacist notices do not publish a pharmacist-specific item count, fee, or numeric pass mark; legacy PPB professional-exam material for technologists used 100 MCQs plus 20 SAQs per paper and a 50% aggregate pass mark.

What is the published resit rule?

PPB's exams page states that a candidate who fails any PPB examination, including Stage I or Stage II, may be allowed to resit up to a maximum of two times within five years.