Free Practice Questions for EPLE

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Exam Review

Key Facts: EPLE Exam

Official MCQs

2 Hours

Maximum Sitting Time

Pass/Fail

Result Reporting

Competency Domains

The Egypt Pharmacist Licensure Examination (EPLE) is administered by the Egyptian Health Council (EHC) in accordance with Law No. 12 of 2022. Passing the examination is legally mandatory for all pharmacy graduates (BPharm / PharmD) to secure a license to practice and register with the Egyptian Syndicate of Pharmacists. The computer-based test consists of 70 MCQs sat within a maximum of two hours, testing Clinical Pharmacy (25%), Pharmacy Practice (25%), Pharmaceutical Competencies (25%), Calculations (15%), and Egyptian Pharmacy Laws and Ethics (10%). Results are issued as pass or fail with no published numeric cut score, and the licence granted on passing runs for a renewable five years. The 100 practice questions on this page are an independent study aid written to the published EPLE blueprint, not official EHC items.

Sample EPLE Practice Questions

Try these sample questions to review concepts for the EPLE exam. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.

1A 58-year-old male with acute anterior ST-elevation myocardial infarction (STEMI) undergoes primary percutaneous coronary intervention (PCI) with a drug-eluting stent. He has no history of stroke or bleeding. Which dual antiplatelet therapy (DAPT) regimen is recommended as first-line according to clinical guidelines?

A.Aspirin 81-100 mg daily plus Ticagrelor 90 mg twice daily for at least 12 months

B.Aspirin 325 mg daily alone without a P2Y12 inhibitor for 6 months

C.Clopidogrel 75 mg daily monotherapy without aspirin for 30 days

D.Aspirin 81 mg daily plus Warfarin with target INR 2.0-3.0 as primary antiplatelet therapy

Explanation: Current ACS guidelines recommend aspirin combined with a potent P2Y12 inhibitor (ticagrelor 90 mg twice daily or prasugrel 10 mg once daily) over clopidogrel for at least 12 months following PCI for STEMI, in the absence of excessive bleeding risk or contraindications.

2A 64-year-old female with heart failure with reduced ejection fraction (HFrEF, LVEF 28%, NYHA Class II) is currently taking carvedilol 25 mg twice daily, empagliflozin 10 mg once daily, and spironolactone 25 mg once daily. She remains mildly symptomatic with blood pressure 126/78 mmHg and serum potassium 4.4 mEq/L. Which medication addition completes the guideline-directed medical therapy (GDMT) four-pillar foundation?

A.Amlodipine 5 mg once daily

B.Sacubitril/valsartan (ARNI) starting at 24/26 mg or 49/51 mg twice daily

C.Digoxin 0.25 mg once daily as first-line therapy

D.Furosemide 80 mg twice daily in the absence of fluid retention

Explanation: Guideline-directed medical therapy (GDMT) for HFrEF consists of four foundational pillars: a beta-blocker (carvedilol, metoprolol succinate, or bisoprolol), an SGLT2 inhibitor, a mineralocorticoid receptor antagonist (MRA), and a renin-angiotensin system inhibitor with ARNI (sacubitril/valsartan) preferred over ACE inhibitors or ARBs.

3A 72-year-old male with non-valvular atrial fibrillation has a history of hypertension and type 2 diabetes mellitus. His CHA2DS2-VASc score is calculated as 3. What is the most appropriate stroke prevention strategy?

A.Aspirin 81 mg daily monotherapy

B.Dual antiplatelet therapy with aspirin and clopidogrel

C.A direct-acting oral anticoagulant (DOAC) such as apixaban or rivaroxaban

D.No antithrombotic therapy because he has no history of prior stroke

Explanation: In male patients with non-valvular atrial fibrillation and a CHA2DS2-VASc score of 2 or higher, oral anticoagulation is strongly recommended. DOACs (apixaban, rivaroxaban, dabigatran, edoxaban) are preferred over warfarin due to superior efficacy in preventing embolic stroke and significantly lower rates of intracranial hemorrhage.

4A 52-year-old woman with type 2 diabetes mellitus presents with blood pressure 148/92 mmHg on two separate visits. Laboratory tests show serum creatinine 1.1 mg/dL, eGFR 78 mL/min/1.73m2, and urine albumin-to-creatinine ratio (UACR) 180 mg/g. Which antihypertensive medication class is the first-line choice for this patient?

A.Non-dihydropyridine calcium channel blocker (e.g., verapamil)

B.Beta-1 selective adrenergic blocker (e.g., atenolol)

C.Loop diuretic (e.g., furosemide)

D.Angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB)

Explanation: In patients with diabetes, hypertension, and persistent microalbuminuria (UACR 30-299 mg/g) or macroalbuminuria (>= 300 mg/g), an ACE inhibitor or ARB is the preferred first-line antihypertensive because it reduces intraglomerular hydrostatic pressure and slows diabetic kidney disease progression.

5A 61-year-old male with type 2 diabetes mellitus and established atherosclerotic cardiovascular disease (prior myocardial infarction 3 years ago) has an HbA1c of 8.2% despite metformin 1,000 mg twice daily. His eGFR is 55 mL/min/1.73m2. According to ADA and EASD consensus recommendations, which antidiabetic agent should be added next?

A.A GLP-1 receptor agonist with proven cardiovascular benefit or an SGLT2 inhibitor

B.A sulfonylurea such as glimepiride 4 mg daily

C.A dipeptidyl peptidase-4 (DPP-4) inhibitor such as sitagliptin

D.A thiazolidinedione such as pioglitazone 45 mg daily

Explanation: In patients with type 2 diabetes and established ASCVD, heart failure, or CKD, international guidelines recommend adding an SGLT2 inhibitor or a GLP-1 receptor agonist with demonstrated cardiovascular benefit regardless of baseline HbA1c or individualized HbA1c target.

6A 24-year-old female is admitted to the intensive care unit with diabetic ketoacidosis (DKA). Initial blood tests reveal plasma glucose 480 mg/dL, arterial pH 7.15, serum bicarbonate 10 mEq/L, and serum potassium 3.1 mEq/L. What is the immediate priority regarding insulin administration?

A.Administer an immediate IV bolus of regular insulin at 0.14 units/kg followed by continuous infusion

B.Withhold insulin infusion and administer IV potassium repletion until serum potassium exceeds 3.3 mEq/L

C.Administer rapid-acting insulin subcutaneously every 2 hours while giving IV sodium bicarbonate

D.Start continuous regular insulin infusion at 0.1 units/kg/hour immediately without potassium replacement

Explanation: In DKA management, insulin drives potassium intracellularly and will exacerbate existing hypokalemia. If baseline serum potassium is below 3.3 mEq/L, insulin administration must be withheld while IV potassium chloride (20-30 mEq/hour) is infused until potassium rises above 3.3 mEq/L to prevent fatal cardiac arrhythmias and respiratory muscle paralysis.

7A 35-year-old male with persistent asthma has daytime symptoms 4 days per week and awakens with cough and wheezing twice per month. According to GINA recommendations (Track 1 preferred approach), what is the optimal maintenance and reliever therapy?

A.Short-acting beta-2 agonist (albuterol) as-needed alone without anti-inflammatory therapy

B.High-dose oral prednisone daily combined with as-needed ipratropium bromide

C.Low-dose inhaled corticosteroid (ICS) combined with formoterol taken as both daily controller and as-needed reliever (SMART/MART)

D.Oral theophylline extended-release tablets plus as-needed salmeterol monotherapy

Explanation: GINA guidelines recommend an inhaled corticosteroid (ICS) combined with formoterol (a rapid-onset, long-acting beta-2 agonist) as the preferred reliever across all asthma stages, and as combined maintenance and reliever therapy (SMART/MART) for persistent disease to reduce severe exacerbations.

8A 68-year-old male with COPD (GOLD Group E) experiences an acute exacerbation with increased dyspnea, increased sputum volume, and increased sputum purulence. He is afebrile and his SpO2 is 90% on room air. In addition to short-acting bronchodilators, which pharmacotherapy regimen is indicated?

A.A 30-day course of high-dose intravenous dexamethasone with prophylactic antifungal therapy

B.Inhaled fluticasone monotherapy without oral corticosteroids or antibiotics

C.Intravenous aminophylline infusion plus long-term macrolide monotherapy for 6 months

D.Oral prednisone 40 mg daily for 5 days plus an empiric oral antibiotic for 5-7 days

Explanation: GOLD guidelines recommend oral systemic corticosteroids (prednisone 40 mg daily for 5 days) to accelerate recovery and reduce relapse risk. Antibiotics (such as amoxicillin/clavulanate, azithromycin, or doxycycline for 5-7 days) are indicated when all three cardinal symptoms (dyspnea, sputum volume, sputum purulence) are present.

9A 56-year-old female with chronic heart failure and type 2 diabetes is diagnosed with mild community-acquired pneumonia (CAP) suitable for outpatient treatment. She has no drug allergies. Which empiric antimicrobial regimen is recommended by ATS/IDSA guidelines?

A.A beta-lactam plus a macrolide, or respiratory fluoroquinolone monotherapy

B.Oral amoxicillin 500 mg three times daily alone as monotherapy

C.Oral ciprofloxacin 500 mg twice daily monotherapy for 14 days

D.Intravenous vancomycin 15 mg/kg every 12 hours administered at home

Explanation: For outpatient CAP in patients with chronic comorbidities (heart failure, diabetes, lung/renal disease), ATS/IDSA guidelines recommend either combination therapy (beta-lactam e.g. amoxicillin/clavulanate or cefuroxime plus a macrolide or doxycycline) or respiratory fluoroquinolone monotherapy (levofloxacin 750 mg or moxifloxacin 400 mg) to cover Streptococcus pneumoniae and atypical pathogens.

10A 62-year-old intubated patient develops ventilator-associated pneumonia (VAP) 6 days after ICU admission. Hospital antibiograms indicate high rates of MRSA and multidrug-resistant Pseudomonas aeruginosa. Which empiric antibiotic combination is most appropriate?

A.Oral ampicillin plus oral azithromycin

B.Intravenous vancomycin or linezolid plus two antipseudomonal agents from different classes

C.Intravenous ceftriaxone monotherapy at 2 g once daily

D.Intravenous clindamycin plus metronidazole

Explanation: IDSA/ATS hospital-acquired and ventilator-associated pneumonia guidelines recommend empiric therapy covering MRSA (vancomycin or linezolid) plus two antipseudomonal agents from different pharmacological classes (such as an antipseudomonal beta-lactam like piperacillin/tazobactam or cefepime, plus an aminoglycoside like amikacin or an antipseudomonal fluoroquinolone like ciprofloxacin) in settings with high resistance risks.

About the EPLE Exam

The EPLE is Egypt's mandatory national licensing examination for pharmacy graduates, established under Law No. 12 of 2022 to assess clinical competency, safe medication practice, pharmaceutical sciences, calculations, and legal compliance prior to professional registration.

Exam sponsor: Egyptian Health Council (EHC). The requirements and fees below concern the certification or admission exam, separate from our free practice resources.

Assessment

The Egypt Pharmacist Licensure Examination (EPLE / اختبار مزاولة مهنة الصيدلة) is administered by the Egyptian Health Council (EHC) under Law No. 12 of 2022. It is a mandatory national licensure assessment required for all pharmacy graduates before obtaining a license to practice pharmacy from the Ministry of Health and Population and registering with the Egyptian Syndicate of Pharmacists. The live examination features 70 single-best-answer MCQs mapped to the published EPLE Blueprint across five competency domains: Clinical Pharmacy Competencies (25%, 18 items), Pharmacy Practice Competencies (25%, 18 items), Pharmaceutical Competencies (25%, 17 items), Pharmaceutical Calculations (15%, 10 items), and Laws, Legislations, Ethics and Professionalism (10%, 7 items). The EHC pharmacy exam page sets a maximum of two hours; each round announcement fixes the actual sitting length, most recently 75 minutes. Each round runs a mock exam, a simulation exam, and multiple real exams, and the candidate's result is taken from the last real exam attempted.

Time Limit

Up to 2 hours per the EHC exam page; recent round announcements set 75 minutes

Passing Score

Reported as pass or fail without grades; EHC does not publish a numeric cut score.

Exam / Certification Fees

EGP 200 for Egyptian candidates for the first attempt, plus electronic payment service charges; EHC round announcements do not publish a fee figure for non-Egyptian candidates.

Exam sponsor website

Reported exam pass rate: Not publicly published as a continuous official series by the Egyptian Health Council.. EHC publishes eligibility rules, scheduling notices, and the EPLE blueprint, but official national pass rate statistics are not released publicly. Exam sponsor website

Fees, eligibility, and exam policies can change. Confirm them with the exam sponsor before applying or paying.

Official sources

Our practice resources: topics covered

We aim to reflect publicly available exam outlines and topic information in our study resources. Coverage, format, and difficulty may differ from the actual exam, and we cannot guarantee that every detail is accurate or current. Confirm exam requirements, fees, and policies with the official exam sponsor.

25% of exam (18 of 70 official items)

Clinical Pharmacy Competencies

Pathophysiology and pharmacotherapy of cardiovascular, respiratory, endocrine, infectious, gastrointestinal, renal, and neurologic diseases.

25% of exam (18 of 70 official items)

Pharmacy Practice Competencies

Medication therapy management, clinical drug interactions, contraindications, adverse drug reactions, patient education, cold chain storage, and community pharmacy dispensing.

25% of exam (17 of 70 official items)

Pharmaceutical Competencies

Physicochemical principles of dosage forms, stability testing, drug delivery systems, bioavailability, bioequivalence, excipients, sterilization methods, and packaging.

15% of exam (10 of 70 official items)

Pharmaceutical Calculations

Clinical and compounding calculations: Cockcroft-Gault renal clearance, milliequivalents, osmolarity, percentage concentrations, alligation, pediatric dosing rules, and IV flow rates.

10% of exam (7 of 70 official items)

Laws, Legislations, Ethics, and Professionalism

Egyptian Pharmacy Law No. 127 of 1955, EDA Law No. 151 of 2019, EHC Law No. 12 of 2022, Anti-Narcotics Law No. 182 of 1960 schedules, prescription storage rules, and ethical duties.

Preparing for the EPLE Exam

What You Need to Know

Passing score: Reported as pass or fail without grades; EHC does not publish a numeric cut score.
Assessment: The Egypt Pharmacist Licensure Examination (EPLE / اختبار مزاولة مهنة الصيدلة) is administered by the Egyptian Health Council (EHC) under Law No. 12 of 2022. It is a mandatory national licensure assessment required for all pharmacy graduates before obtaining a license to practice pharmacy from the Ministry of Health and Population and registering with the Egyptian Syndicate of Pharmacists. The live examination features 70 single-best-answer MCQs mapped to the published EPLE Blueprint across five competency domains: Clinical Pharmacy Competencies (25%, 18 items), Pharmacy Practice Competencies (25%, 18 items), Pharmaceutical Competencies (25%, 17 items), Pharmaceutical Calculations (15%, 10 items), and Laws, Legislations, Ethics and Professionalism (10%, 7 items). The EHC pharmacy exam page sets a maximum of two hours; each round announcement fixes the actual sitting length, most recently 75 minutes. Each round runs a mock exam, a simulation exam, and multiple real exams, and the candidate's result is taken from the last real exam attempted.
Time limit: Up to 2 hours per the EHC exam page; recent round announcements set 75 minutes
Exam / certification fees: EGP 200 for Egyptian candidates for the first attempt, plus electronic payment service charges; EHC round announcements do not publish a fee figure for non-Egyptian candidates. Official sources

Using Our Practice Resources

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EPLE: Suggested Study Strategy

1Master the five blueprint domains according to their weight: Clinical Pharmacy (25%), Pharmacy Practice (25%), and Pharmaceutical Competencies (25%) form 75% of your score.

2Practice exact pharmaceutical calculations repeatedly: Cockcroft-Gault CrCl calculations, mEq to mg conversions, osmolarity, percentage solutions, and alligation alternate.

3Review Egyptian pharmacy regulations thoroughly: Law No. 127 of 1955 governing pharmacy practice, Law No. 182 of 1960 on narcotics and psychotropics, and EDA Law No. 151 of 2019.

4Focus on high-yield pharmacotherapy guidelines: hypertension, type 2 diabetes mellitus, asthma/COPD, antimicrobials, anticoagulation, and acute coronary syndromes.

5Understand proper medication counseling and safety checks: identifying major CYP450 drug interactions, drug-food interactions, narrow therapeutic index drugs, and pregnancy contraindications.

Frequently Asked Questions

What is the Egypt Pharmacist Licensure Examination (EPLE)?

The EPLE (اختبار مزاولة مهنة الصيدلة) is Egypt's mandatory national computer-based licensing examination conducted by the Egyptian Health Council (EHC) under Law No. 12 of 2022 for all pharmacy graduates seeking licensure to practice.

Who is required to take the EPLE?

All graduates holding a Bachelor of Pharmacy (BPharm) or Doctor of Pharmacy (PharmD) from Egyptian universities, or equalized foreign pharmacy degrees, who have completed their mandatory training period must pass the EPLE before receiving a practice license.

What is the format and duration of the EPLE?

The official exam consists of 70 multiple-choice questions sat on a remote proctored computer-based platform. The EHC exam page sets a maximum of two hours, and each round announcement fixes the actual sitting length, most recently 75 minutes.

What topics and domain weights are tested on the EPLE?

The blueprint comprises five domains: Clinical Pharmacy Competencies (25%), Pharmacy Practice Competencies (25%), Pharmaceutical Competencies (25%), Pharmaceutical Calculations (15%), and Laws, Legislations, Ethics, and Professionalism (10%).

What is the passing score for the EPLE?

EHC reports the EPLE result as pass or fail without grades and does not publish a numeric cut score. Each round includes several real exam sittings, and the candidate is assessed on the last attempt taken.

Are these practice questions official EHC exam items?

No. These are original, high-yield practice questions authored strictly according to the official EHC blueprint, Egyptian statutory laws, and pharmaceutical clinical guidelines for study and revision.