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Practice Questions100 questions

2026 Statistics

Key Facts: Internat Pharmacie (Côte d'Ivoire) Exam

4 Years

Duration of the hospital residency that successful pharmacy candidates enter

MSHPCMU / DEPPS, launch of the 2025 internat session

20 Posts

Pharmacy internship posts opened in the 2025 national session, alongside 90 in medicine

MSHPCMU communiqué, 2 July 2025

12–16 Oct 2026

Composition window for the 2026 pharmacy competition at UFR Sciences Pharmaceutiques et Biologiques, UFHB Cocody

DEPPS communiqué, 11 August 2026

2020

Year the internat competition in medicine and pharmacy became national under Arrêté n°0204 MSHP/CAB

Arrêté n°0204 MSHP/CAB du 18 août 2020

DEPPS / MSHPCMU

Official governmental authority that organises the competition

Ministère de la Santé de Côte d'Ivoire

Côte d'Ivoire's Concours National d'Internat en Pharmacie is the statutory national competition that recruits hospital resident pharmacists for the CHUs — 20 posts in the 2025 session — and opens the way to the DES in biologie médicale and pharmacie hospitalière. Covering medical biology, pharmacology and toxicology, analytical chemistry, and galenic and hospital pharmacy, this bank is a 100-question English-language MCQ study adaptation of that curriculum, not an official translation of the French-language papers.

Sample Internat Pharmacie (Côte d'Ivoire) Practice Questions

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1A complete blood count (CBC / NFS) of an anemic patient (Hb 7.8 g/dL) reveals: Mean Corpuscular Volume (MCV) 92 fL, Mean Corpuscular Hemoglobin (MCH) 30 pg, and an absolute reticulocyte count of 220,000/μL (regenerative index >2%). What is the physiological classification of this anemia?

A.Normocytic normochromic regenerative anemia (e.g., acute hemorrhage or acute hemolysis)

B.Microcytic hypochromic non-regenerative anemia (e.g., iron deficiency)

C.Macrocytic megaloblastic non-regenerative anemia (e.g., vitamin B12 deficiency)

D.Normocytic normochromic aregenerative anemia (e.g., bone marrow aplasia or chronic renal failure)

Explanation: An anemia with an MCV between 80–100 fL is normocytic, with an MCH between 27–32 pg is normochromic, and with an absolute reticulocyte count >120,000–150,000/μL is classified as regenerative. This reflects appropriate compensatory erythroid hyperplasia in the bone marrow, seen in peripheral red cell destruction (hemolysis) or acute blood loss.

2In the laboratory differential diagnosis of microcytic hypochromic anemia (MCV <80 fL), which biochemical iron profile distinguishes pure iron deficiency anemia from anemia of chronic disease (anémie inflammatoire)?

A.Iron deficiency anemia shows low serum ferritin (<15–30 μg/L) and elevated Total Iron-Binding Capacity (TIBC), whereas anemia of chronic disease shows normal/elevated ferritin and normal/low TIBC

B.Iron deficiency shows high serum ferritin (>300 μg/L) and low soluble transferrin receptors

C.Anemia of chronic disease shows low serum ferritin and elevated transferrin saturation (>50%)

D.Both conditions show high serum iron and high transferrin saturation

Explanation: Serum ferritin is the most reliable parameter reflecting total body iron stores. In iron deficiency anemia, ferritin is low (<30 μg/L) and transferrin synthesis increases (elevated TIBC). In chronic inflammatory anemia, inflammatory cytokines (IL-6) upregulate hepcidin, trapping iron inside macrophages, resulting in normal or elevated ferritin (>100 μg/L) and low transferrin/TIBC.

3Which combination of biological laboratory findings is pathognomonic for intravascular hemolytic anemia?

A.Collapsed (undetectable) serum haptoglobin, elevated serum unconjugated bilirubin, elevated serum lactate dehydrogenase (LDH), reticulocytosis, and hemoglobinuria

B.Elevated serum haptoglobin, elevated direct conjugated bilirubin, and low LDH

C.Elevated serum ferritin, normal haptoglobin, and severe reticulocytopenia

D.Isolated elevation of alkaline phosphatase (ALP) with normal bilirubin and normal haptoglobin

Explanation: During intravascular hemolysis, free hemoglobin released into the circulation binds irreversibly to serum haptoglobin, leading to rapid clearance by the reticuloendothelial system and resulting in undetectable (collapsed) haptoglobin. Excess free hemoglobin spills into urine (hemoglobinuria). Heme breakdown increases unconjugated bilirubin, cell lysis releases intracellular LDH, and bone marrow accelerates output (reticulocytosis).

4A peripheral blood smear and bone marrow aspirate in a 45-year-old patient show 40% blast cells with folded nuclei, granular cytoplasm containing crystalline Auer rods, and intense positivity for Myeloperoxidase (MPO) and Sudan Black B on cytochemical staining. What is the diagnosis?

A.Acute Myeloid Leukemia (AML / Leucémie Aiguë Myéloblastique)

B.Acute Lymphoblastic Leukemia (ALL / B-ALL)

C.Chronic Lymphocytic Leukemia (CLL / LLC)

D.Multiple Myeloma (Myélome multiple)

Explanation: Auer rods are pathognomonic crystalline aggregates of fused azurophilic granules found exclusively in malignant myeloid lineage blasts. Strong cytochemical positivity for Myeloperoxidase (MPO) confirms the myeloid lineage, establishing the diagnosis of Acute Myeloid Leukemia (AML).

5What is the hallmark reciprocal chromosomal translocation and resulting fusion oncogene diagnostic of Chronic Myeloid Leukemia (CML / LMC), which serves as the therapeutic target for tyrosine kinase inhibitors (e.g., imatinib)?

A.t(9;22)(q34;q11) translocation creating the BCR-ABL1 fusion gene on the Philadelphia (Ph) chromosome

B.t(15;17)(q22;q12) translocation creating the PML-RARA fusion gene

C.t(8;14)(q24;q32) translocation involving the c-MYC and IgH genes

D.t(11;14)(q13;q32) translocation creating the CCND1-IgH fusion gene

Explanation: Chronic Myeloid Leukemia (CML) is defined by the t(9;22)(q34;q11) reciprocal translocation, which transposes the ABL1 proto-oncogene from chromosome 9 to the BCR gene on chromosome 22, creating the shortened Philadelphia (Ph) chromosome. The BCR-ABL1 chimeric gene encodes a constitutively active tyrosine kinase driving granulocytic proliferation, targeted by imatinib.

6A patient presents with recurrent mucosal bleeding, epistaxis, and menorrhagia. Coagulation panel shows: normal platelet count (250,000/μL), normal Prothrombin Time (PT / TP), prolonged activated Partial Thromboplastin Time (aPTT / TCA), prolonged closure time on PFA-100, and decreased ristocetin cofactor activity (VWF:RCo). What is the diagnosis?

A.von Willebrand Disease (Maladie de Willebrand)

B.Hemophilia B (Factor IX deficiency)

C.Factor VII deficiency

D.Glanzmann Thrombasthenia

Explanation: von Willebrand disease is the most common inherited bleeding disorder, caused by quantitative or qualitative defects in von Willebrand factor (VWF). Because VWF mediates platelet adhesion to subendothelial collagen (tested by PFA-100 and ristocetin agglutination) and protects Factor VIII from degradation, VWF deficiency impairs primary hemostasis and causes secondary Factor VIII deficiency with a prolonged aPTT.

7In the clinical laboratory evaluation of hemostasis, which coagulation factors are specifically explored by the Prothrombin Time (PT / Taux de Prothrombine / Quick's test)?

A.Extrinsic and common pathway factors: Factors VII, X, V, II (prothrombin), and I (fibrinogen)

B.Intrinsic pathway factors: Factors XII, XI, IX, and VIII

C.Factors VIII and IX only

D.Protein C and Protein S exclusively

Explanation: The Prothrombin Time (PT / TP) measures the clotting time of plasma in the presence of tissue factor (thromboplastin) and calcium, exploring the extrinsic pathway (Factor VII) and the common pathway (Factors X, V, II, and I). It is standardized internationally using the International Normalized Ratio (INR).

8A 4-year-old boy presents with painful spontaneous hemarthrosis of the right knee following minor trauma. Coagulation screen reveals: normal platelet count, normal PT/TP (100%), prolonged aPTT/TCA (ratio 2.5) that corrects completely when mixed 1:1 with normal control plasma (Rosner index <11). Specific factor assays reveal Factor VIII activity <1% and normal Factor IX activity (100%). What is the diagnosis and inheritance pattern?

A.Severe Hemophilia A (Hémophilie A sévère); X-linked recessive inheritance

B.Hemophilia B (Christmas disease); Autosomal dominant inheritance

C.Factor XIII deficiency; Autosomal recessive inheritance

D.Acquired Factor VIII inhibitor; Autoimmune non-hereditary disorder

Explanation: Hemophilia A is an X-linked recessive bleeding disorder caused by mutations in the F8 gene on the X chromosome leading to deficiency of coagulation Factor VIII. Severe hemophilia is defined by baseline factor activity <1%, presenting with spontaneous joint hemorrhages (hemarthroses). The 1:1 mixing study corrects because normal plasma supplies the missing factor (unlike circulating inhibitors).

9What is the most prevalent hereditary thrombophilia in Caucasian and mixed populations, characterized by resistance of activated Factor V to proteolytic inactivation by Activated Protein C (APC)?

A.Factor V Leiden mutation (G1691A point mutation in the F5 gene replacing Arg506 with Gln)

B.Prothrombin G20210A gene mutation

C.Congenital Antithrombin III deficiency

D.Homozygous Protein S deficiency

Explanation: Factor V Leiden (a single point mutation at nucleotide 1691 G->A in the F5 gene resulting in Arg506Gln substitution) eliminates the primary cleavage site for Activated Protein C (APC). The mutated Factor Va resists APC-mediated degradation, leading to continuous prothrombinase activity and a 3- to 8-fold increased relative risk of venous thromboembolism in heterozygotes.

10In clinical nephrology and pharmacokinetics, what is the classic Cockcroft-Gault formula used to estimate creatinine clearance (CrCl in mL/min) in adult males, and what correction factor is applied for female patients?

A.CrCl = [(140 - Age in years) × Weight in kg] / [72 × Serum Creatinine in mg/dL]; Multiply by 0.85 for females

B.CrCl = [Age × Serum Creatinine] / [140 × Weight]; Multiply by 1.15 for females

C.CrCl = [140 - Age] / [Weight × Serum Creatinine]; Multiply by 0.50 for females

D.CrCl = Serum Creatinine × 186 × (Age)^(-0.203); Multiply by 0.742 for females

Explanation: The Cockcroft-Gault equation estimates creatinine clearance: CrCl (mL/min) = [(140 - Age) × Weight (kg)] / [72 × Serum Creatinine (mg/dL)], or / [0.814 × Creatinine (μmol/L)]. For females, the result is multiplied by 0.85 to account for their lower average muscle mass relative to total body weight.

About the Internat Pharmacie (Côte d'Ivoire) Exam

The Concours National d'Internat en Pharmacie is the premier national competitive examination in Côte d'Ivoire organized by the DEPPS/MSHPCMU to recruit hospital resident pharmacists for public hospital laboratories, clinical pharmacy departments, and academic careers.

Assessment

Written competitive examination instituted by Arrêté n°0204 MSHP/CAB du 18 août 2020 (which created a national internat competition in both medicine and pharmacy) and governed by Décret n°2018-345 du 21 mars 2018 on the recruitment and status of hospital interns. Sat over a multi-day composition window at the UFR des Sciences Pharmaceutiques et Biologiques, UFHB Cocody, with rank-order merit admission into the CHU pharmacy residency posts opened by decree. The DEPPS does not publish the paper list or their coefficients.

Time Limit

5-day composition window (12–16 October 2026 for the 2026 session)

Passing Score

Rank-order merit selection (concours classant) against the posts opened by decree — 20 pharmacy posts in the 2025 session. No statutory pass mark is published for the pharmacy competition.

Exam Fee

Not published for pharmacy; the two published 2025-2026 internat decrees set the candidacy fee at 50,000 FCFA — confirm with the DEPPS (Ministère de la Santé / DEPPS & MESRS (Côte d'Ivoire))

Internat Pharmacie (Côte d'Ivoire) Exam Content Outline

Study area

Biologie Médicale

Clinical hematology, hemostasis, clinical biochemistry, metabolic diseases, bacteriology, antibiograms, medical parasitology-mycology, virology (HIV/Hepatitis), and clinical immunology.

Study area

Pharmacologie & Toxicologie

Pharmacokinetics (Vd, clearance, half-life), pharmacodynamics, antimicrobial agents, antimalarials (ACT), cardiovascular drugs, acute poisonings (paracetamol, opioids, organophosphates), and therapeutic drug monitoring.

Study area

Chimie Analytique & Sciences Fondamentales

UV-Visible spectrophotometry, Beer-Lambert law, HPLC, gas chromatography, mass spectrometry, IR spectroscopy, titrimetric methods, and ICH analytical validation.

Study area

Pharmacie Galénique, Hospitalière & Clinique

Tablet and capsule formulation, parenteral preparations, autoclave sterilization, cleanrooms (ZAC), cytotoxic compounding, hospital inventory management, medication reconciliation, and Ivorian pharmacy laws (AIRP). No official coefficients are published for the pharmacy internat, so this split is our editorial choice.

How to Pass the Internat Pharmacie (Côte d'Ivoire) Exam

What You Need to Know

Passing score: Rank-order merit selection (concours classant) against the posts opened by decree — 20 pharmacy posts in the 2025 session. No statutory pass mark is published for the pharmacy competition.
Assessment: Written competitive examination instituted by Arrêté n°0204 MSHP/CAB du 18 août 2020 (which created a national internat competition in both medicine and pharmacy) and governed by Décret n°2018-345 du 21 mars 2018 on the recruitment and status of hospital interns. Sat over a multi-day composition window at the UFR des Sciences Pharmaceutiques et Biologiques, UFHB Cocody, with rank-order merit admission into the CHU pharmacy residency posts opened by decree. The DEPPS does not publish the paper list or their coefficients.
Time limit: 5-day composition window (12–16 October 2026 for the 2026 session)
Exam fee: Not published for pharmacy; the two published 2025-2026 internat decrees set the candidacy fee at 50,000 FCFA — confirm with the DEPPS

Keys to Passing

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Internat Pharmacie (Côte d'Ivoire) Study Tips from Top Performers

1Master the interpretation of clinical laboratory panels: differentiate regenerative from non-regenerative anemias, calculate LDL-C using the Friedewald formula, and know coagulation cascade pathways (TP vs aPTT).

2Memorize key toxicological mechanisms and specific antidotes: paracetamol (N-acetylcysteine), organophosphates (atropine + pralidoxime), opioids (naloxone), benzodiazepines (flumazenil), and digoxin (Fab fragments).

3Review chromatographic parameters thoroughly: understand HPLC capacity factor (k'), resolution (Rs ≥1.5), plate count (N), and retention mechanisms in reverse-phase chromatography.

4Thoroughly review parenteral formulation requirements, including isotonicity calculations, pyrogen testing (LAL assay), and autoclave sterilization parameters (121°C for 15 minutes).

5Focus on clinical pharmacy protocols: medication reconciliation, therapeutic drug monitoring of narrow therapeutic index drugs (aminoglycosides, vancomycin, lithium), and drug-drug interactions mediated by Cytochrome P450.

Frequently Asked Questions

What is the Concours National d'Internat de Pharmacie in Côte d'Ivoire?

The Concours National d'Internat de Pharmacie is the official state competitive examination organized by the Direction des Établissements Privés et des Professions Sanitaires (DEPPS) under the Ministère de la Santé, de l'Hygiène Publique et de la Couverture Maladie Universelle (MSHPCMU). It selects elite pharmacy students to become hospital pharmacy interns (Internes en Pharmacie des Hôpitaux) in public university hospital centers (CHU) and specialized laboratories.

Who is eligible to sit the pharmacy internat competition?

Candidates are pharmacy students who have not yet defended their Doctorat d'État en Pharmacie thesis. The precise academic milestone is set in the pharmacy opening decree, which the DEPPS has not published online — the sibling 2025-2026 decrees require the 11th semester in medicine and Master 1 in odonto-stomatologie. Confirm the current pharmacy requirement directly with the DEPPS.

What disciplines are tested during the competition?

The competition draws on the Ivorian pharmacy curriculum: medical biology (haematology, clinical biochemistry, bacteriology, parasitology, virology, immunology), pharmacology and toxicology, analytical chemistry, and galenic, hospital and clinical pharmacy. The DEPPS does not publish a paper list or coefficients, so this bank's split across those areas is our editorial choice rather than an official weighting.

What career opportunities follow success in the Internat en Pharmacie?

Successful candidates are appointed as Internes en Pharmacie for a four-year residency program, receiving specialized clinical and laboratory training, a public hospital salary, and direct eligibility for academic hospital careers (Assistanat / Maîtrise de Conférences) and Diplôme d'Études Spécialisées (DES) in Medical Biology or Hospital Pharmacy.

Why is this question bank presented in English?

While the official examination in Côte d'Ivoire is sat in French, this question bank provides an English-language MCQ study adaptation aligned with the official national syllabus. It is designed to reinforce core biological, analytical, toxicological, and galenic concepts for candidates preparing for clinical assessments and international pharmaceutical standards.