100+ Free PEBC OSCE Practice Questions

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A 70-year-old presents with a prescription for ramipril and reports a dry, persistent cough that started two weeks after beginning the drug. The MOST appropriate clinical action is to:

Reassure her the cough is unrelated and continue ramipril

Identify the ACE-inhibitor cough and recommend the prescriber consider switching to an ARB

Recommend an over-the-counter cough suppressant indefinitely

Double the ramipril dose to control blood pressure faster

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Sample PEBC OSCE Practice Questions

Try these sample questions to test your PEBC OSCE exam readiness. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.

1At an interactive OSCE station, a 58-year-old man newly started on warfarin for non-valvular atrial fibrillation asks what his blood test target should be. According to standard Canadian practice, what INR target and range should you counsel?

A.Target INR 2.5 (range 2.0-3.0)

B.Target INR 3.5 (range 3.0-4.0)

C.Target INR 1.5 (range 1.0-2.0)

D.Target INR 4.0 (range 3.5-4.5)

Explanation: For most indications including non-valvular atrial fibrillation and venous thromboembolism, the standard target INR is 2.5 with an acceptable range of 2.0-3.0. Counselling the correct target lets the patient understand monitoring goals and recognize out-of-range values.

2A patient at a counselling station is starting metformin 500 mg twice daily for type 2 diabetes. Which counselling point is MOST important to improve tolerability and adherence?

A.Take it on an empty stomach to maximize absorption

B.Take it with meals to reduce gastrointestinal upset

C.Stop the drug permanently if any loose stools occur

D.Avoid all carbohydrate-containing foods while on metformin

Explanation: Gastrointestinal side effects (nausea, diarrhea) are the most common cause of metformin intolerance and are reduced by taking it with food and titrating the dose slowly. This counselling supports adherence to first-line therapy.

3At an interactive station, a simulated patient hands you a new prescription for sumatriptan and mentions she also takes a daily SSRI for depression. What drug therapy problem should you prioritize when assessing this combination?

A.Risk of hypoglycemia

B.Risk of QT shortening

C.Risk of serotonin syndrome

D.Risk of hyperkalemia

Explanation: Triptans and SSRIs both increase serotonergic activity, so the combination carries a theoretical risk of serotonin syndrome. The pharmacist should assess symptoms, counsel the patient on warning signs (agitation, tremor, hyperthermia), and document the assessment.

4A 70-year-old presents with a prescription for ramipril and reports a dry, persistent cough that started two weeks after beginning the drug. The MOST appropriate clinical action is to:

A.Reassure her the cough is unrelated and continue ramipril

B.Recommend an over-the-counter cough suppressant indefinitely

C.Double the ramipril dose to control blood pressure faster

D.Identify the ACE-inhibitor cough and recommend the prescriber consider switching to an ARB

Explanation: A dry cough is a well-recognized ACE-inhibitor class effect mediated by bradykinin accumulation. The appropriate response is to recognize the adverse effect and recommend the prescriber consider an angiotensin receptor blocker (ARB), which does not cause cough.

5At a non-interactive station you receive a prescription: "Amoxicillin 500 mg PO TID x 10 days" for a patient whose chart documents a history of anaphylaxis to penicillin. What is the BEST course of action?

A.Dispense as written since the dose is appropriate

B.Dispense but add an auxiliary allergy label

C.Withhold dispensing and contact the prescriber to address the documented penicillin anaphylaxis

D.Substitute cephalexin without contacting the prescriber

Explanation: Amoxicillin is a penicillin; dispensing it to a patient with documented penicillin anaphylaxis could be fatal. The pharmacist must withhold dispensing and contact the prescriber to clarify and select a safe alternative. This reflects core patient-safety competency.

6A patient picking up a new salbutamol metered-dose inhaler asks how to use it. Which step sequence reflects correct technique you should demonstrate?

A.Inhale first, then actuate after holding breath

B.Actuate twice rapidly while exhaling, then inhale

C.Place inhaler in mouth, breathe normally, and actuate at the end of exhalation

D.Shake, exhale fully, actuate while inhaling slowly and deeply, hold breath ~10 seconds

Explanation: Correct MDI technique is to shake the canister, exhale fully, then actuate at the start of a slow deep inhalation and hold the breath about 10 seconds to allow drug deposition. Demonstrating and teaching back this technique is a common OSCE counselling task.

7During a Best Possible Medication History (BPMH) interview at an OSCE station, which source combination provides the MOST reliable medication history?

A.At least two sources, e.g., patient interview plus a pharmacy/provincial medication profile

B.The patient's memory alone

C.A single pharmacy fill record only

D.The hospital admission note only

Explanation: A BPMH should be based on more than one source, typically a structured patient or caregiver interview combined with at least one other source such as a community pharmacy profile or provincial drug record, to reconcile discrepancies and capture over-the-counter and as-needed medications.

8A simulated patient with newly diagnosed type 2 diabetes (A1C 7.2%, eGFR 80, no cardiovascular disease) asks about first-line drug therapy. Reflecting current Canadian guidance, which agent is the usual first-line pharmacologic choice?

A.Glyburide

B.Metformin

C.Insulin glargine

D.Pioglitazone

Explanation: For most patients with type 2 diabetes and adequate renal function, metformin is the standard first-line pharmacotherapy after lifestyle measures because of its efficacy, weight neutrality, low hypoglycemia risk, and cost. The OSCE expects the pharmacist to recommend evidence-based first-line therapy.

9At a station, a patient on simvastatin reports new, diffuse muscle aches and dark urine. What is the MOST appropriate immediate pharmacist action?

A.Tell the patient this is a normal statin effect and continue

B.Recommend doubling the statin dose to override the symptom

C.Add a second statin to improve cholesterol control

D.Suspect myopathy/rhabdomyolysis, advise stopping the statin, and arrange urgent medical assessment with CK testing

Explanation: Diffuse myalgia with dark urine suggests statin-induced myopathy and possible rhabdomyolysis, a medical emergency. The pharmacist should recommend stopping the statin and seeking urgent assessment including a creatine kinase (CK) measurement.

10A pregnant patient (first trimester) at a counselling station asks for a recommendation for occasional mild headache. Which analgesic is generally considered the preferred non-prescription option in pregnancy?

A.Ibuprofen

B.Acetylsalicylic acid (ASA)

C.Acetaminophen

D.Naproxen

Explanation: Acetaminophen at recommended doses is generally regarded as the preferred first-line non-prescription analgesic during pregnancy. NSAIDs and ASA are generally avoided, particularly in the third trimester, due to fetal risks.

About the PEBC OSCE Exam

The PEBC Qualifying Examination Part II (OSCE) is the objective structured clinical examination required for pharmacist licensure in Canada. It uses 11 stations (9 interactive with simulated participants and 2 non-interactive) to assess clinical care, patient counselling, communication, drug-therapy decisions, dispensing accuracy, and ethical and legal practice against the 2024 NAPRA entry-to-practice competencies.

Assessment

11 OSCE stations: 9 interactive stations with Simulated Participants plus 2 non-interactive (written) stations, organized into two sessions; 7 minutes per station.

Time Limit

Approximately 6.5 hours at the exam centre; 7 minutes per station with timed transitions and rest stations

Passing Score

Criterion-referenced pass/fail standard established for each exam through a standard-setting (borderline-candidate) process; results reported as Pass/Fail

Exam Fee

CAD $1,915 for Qualifying Examination Part II (OSCE), 2026 (Pharmacy Examining Board of Canada)

PEBC OSCE Exam Content Outline

40%

Providing Care: Clinical Care

Obtaining patient information, assessing health status, and developing, implementing and monitoring patient care plans, including identifying and resolving drug therapy problems.

28%

Communication and Collaboration

Effective verbal and written communication, partnering with patients, collaborating with the health care team, and documenting care and records.

14%

Professionalism

Adhering to legislation and regulation, applying ethics, promoting equity, diversity and inclusion, and supporting a culture of patient safety and quality improvement.

Providing Care: Distribution

Reviewing and processing prescriptions, preparing and verifying dispensed products, releasing verified products, and managing inventory.

Knowledge and Expertise

Using professional judgment to make evidence-informed decisions in the best interests of the patient.

Leadership and Stewardship

Promoting public and community health and wellness, including immunization, health promotion, and antimicrobial stewardship.

How to Pass the PEBC OSCE Exam

What You Need to Know

Passing score: Criterion-referenced pass/fail standard established for each exam through a standard-setting (borderline-candidate) process; results reported as Pass/Fail
Assessment: 11 OSCE stations: 9 interactive stations with Simulated Participants plus 2 non-interactive (written) stations, organized into two sessions; 7 minutes per station.
Time limit: Approximately 6.5 hours at the exam centre; 7 minutes per station with timed transitions and rest stations
Exam fee: CAD $1,915 for Qualifying Examination Part II (OSCE), 2026

Keys to Passing

Complete 500+ practice questions
Score 80%+ consistently before scheduling
Focus on highest-weighted sections
Use our AI tutor for tough concepts

PEBC OSCE Study Tips from Top Performers

1Practice short, structured patient encounters under a 7-minute timer: gather information, assess, make a clear recommendation, counsel, and confirm understanding with teach-back.

2Master Canadian-specific knowledge: NAPRA drug schedules, Narcotic Control Regulations, privacy legislation, and common drug-therapy problems, since these appear across interactive and non-interactive stations.

3Because Communication and Collaboration is weighted far higher on the OSCE (28%) than on the MCQ, rehearse empathy, open-ended questioning, conflict de-escalation, and interprofessional communication such as SBAR.

Frequently Asked Questions

How many stations are on the PEBC OSCE (Part II)?

The PEBC Pharmacist Qualifying Examination Part II consists of 11 examination stations: 9 interactive stations with Simulated Participants and 2 non-interactive written stations, plus rest stations. Each station is 7 minutes long.

What is the passing score for the PEBC OSCE?

There is no fixed percentage. PEBC uses a criterion-referenced pass/fail standard set through a standard-setting process based on the performance expected of a borderline-qualified candidate, and results are reported only as Pass or Fail.

How much does the PEBC Qualifying Exam Part II (OSCE) cost in 2026?

The 2026 fee for the Qualifying Examination Part II (OSCE) is CAD $1,915, payable to the Pharmacy Examining Board of Canada. Part I (MCQ) is a separate exam with its own fee.

What competencies does the PEBC OSCE assess?

The OSCE is based on the 2024 NAPRA entry-to-practice competencies. In the May 2026 blueprint, OSCE weightings are Clinical Care 40%, Communication and Collaboration 28%, Professionalism 14%, Distribution 8%, Knowledge and Expertise 7%, and Leadership and Stewardship 3%.