100+ Free GPhC CRA Part 1 (Calculations) Practice Questions

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A medicine is dosed at 1.5 mg/kg/day in three divided doses. The patient weighs 60 kg. What is the amount, in milligrams, of EACH divided dose?

90 mg

30 mg

45 mg

10 mg

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Sample GPhC CRA Part 1 (Calculations) Practice Questions

Try these sample questions to test your GPhC CRA Part 1 (Calculations) exam readiness. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.

1A 28 kg child is prescribed amoxicillin 30 mg/kg/dose to be given three times a day. What is the quantity, in milligrams, of amoxicillin in EACH dose?

A.840 mg

B.280 mg

C.2520 mg

D.93 mg

Explanation: Weight-based per-dose calculation: 30 mg/kg x 28 kg = 840 mg per dose. The 'three times a day' frequency is not used because the question asks for the amount in each individual dose, not the daily total.

2A patient requires gentamicin 5 mg/kg as a single daily dose. The patient weighs 72 kg. The injection is supplied as 40 mg/mL. What volume, in millilitres, should be drawn up for one dose?

A.7.2 mL

B.9 mL

C.14.4 mL

D.4.5 mL

Explanation: Dose required = 5 mg/kg x 72 kg = 360 mg. Volume = dose / concentration = 360 mg / 40 mg/mL = 9 mL. Always calculate the total dose in milligrams first, then convert to volume using the supplied strength.

3An adult is prescribed prednisolone 40 mg once daily for 5 days. Prednisolone is available as 5 mg tablets. What is the TOTAL number of tablets required to complete the full course?

A.8 tablets

B.200 tablets

C.40 tablets

D.20 tablets

Explanation: Tablets per dose = 40 mg / 5 mg = 8 tablets. Total course = 8 tablets x 5 days = 40 tablets. Calculate tablets per dose first, then multiply by the number of doses across the course.

4A child weighing 15 kg is prescribed paracetamol oral suspension 15 mg/kg every 6 hours. The suspension is 120 mg/5 mL. What volume, in millilitres, is needed for ONE dose?

A.7.5 mL

B.3.75 mL

C.15 mL

D.9.4 mL

Explanation: Dose = 15 mg/kg x 15 kg = 225 mg. Volume = 225 mg / 120 mg x 5 mL = 9.375 mL, which rounds to 9.4 mL. Work out the milligram dose, then convert to volume using the 120 mg/5 mL strength.

5A patient is prescribed ferrous sulfate 200 mg twice daily. Each tablet contains ferrous sulfate 200 mg, providing 65 mg of elemental iron. What is the TOTAL daily intake of elemental iron, in milligrams?

A.130 mg

B.400 mg

C.65 mg

D.260 mg

Explanation: Each tablet provides 65 mg elemental iron and the patient takes two tablets daily, so 65 mg x 2 = 130 mg elemental iron per day. The 200 mg refers to the ferrous sulfate salt, not the elemental iron content.

6An infant weighing 6 kg requires a loading dose of phenytoin 18 mg/kg followed by maintenance of 2.5 mg/kg twice daily. What is the loading dose, in milligrams?

A.15 mg

B.108 mg

C.150 mg

D.45 mg

Explanation: Loading dose = 18 mg/kg x 6 kg = 108 mg. The loading dose uses its own mg/kg figure; the maintenance dose (2.5 mg/kg) is a separate calculation and is not used here.

7A patient is prescribed methotrexate 15 mg ONCE WEEKLY. Tablets are available as 2.5 mg. How many tablets should be supplied for a 4-week (28-day) course?

A.6 tablets

B.168 tablets

C.24 tablets

D.42 tablets

Explanation: Tablets per dose = 15 mg / 2.5 mg = 6 tablets. Methotrexate is given once weekly, so over 4 weeks = 6 x 4 = 24 tablets. The once-weekly frequency is a high-risk feature and must not be mistaken for daily dosing.

8A patient requires a vancomycin dose of 20 mg/kg. The patient weighs 95 kg, but local guidance caps the dose at a maximum of 1500 mg. What dose, in milligrams, should be administered?

A.1900 mg

B.1000 mg

C.475 mg

D.1500 mg

Explanation: Calculated dose = 20 mg/kg x 95 kg = 1900 mg. Because this exceeds the 1500 mg maximum cap, the dose must be reduced to the capped maximum of 1500 mg. Always apply any stated maximum dose limit.

9A child weighing 22 kg is prescribed ibuprofen 10 mg/kg three times daily. The maximum recommended daily dose is 30 mg/kg. What is the maximum total amount of ibuprofen, in milligrams, this child may receive in 24 hours?

A.660 mg

B.220 mg

C.220 mg per dose only

D.2200 mg

Explanation: Maximum daily dose = 30 mg/kg x 22 kg = 660 mg in 24 hours. This is consistent with 10 mg/kg per dose x 3 doses = 30 mg/kg/day, confirming the regimen meets the maximum without exceeding it.

10A patient is started on warfarin and given a total of 15 mg over the first 3 days as follows: 6 mg, 5 mg, then 4 mg. Warfarin is available as 1 mg, 3 mg and 5 mg tablets. Using the FEWEST tablets, how many tablets in total are supplied across these 3 days?

A.15 tablets

B.5 tablets

C.7 tablets

D.4 tablets

Explanation: Day 1: 6 mg = 5 mg + 1 mg = 2 tablets. Day 2: 5 mg = one 5 mg tablet = 1 tablet. Day 3: 4 mg = 3 mg + 1 mg = 2 tablets. Total = 2 + 1 + 2 = 5 tablets using the fewest tablets available.

About the GPhC CRA Part 1 (Calculations) Exam

Part 1 of the GPhC Common Registration Assessment tests pharmacy and healthcare calculations through 40 multi-step, numerical free-entry questions in 120 minutes. All questions reflect realistic UK pharmacy practice scenarios and are aligned with the BNF and BNF for Children, requiring candidates to apply unit conversions, formulae and rounding correctly. Trainee pharmacists must pass Part 1 and Part 2 in the same sitting to be eligible for registration.

Assessment

Part 1 of the two-part Common Registration Assessment: 40 pharmacy and healthcare calculation questions with numerical free-entry responses; an approved calculator is permitted.

Time Limit

120 minutes (2 hours)

Passing Score

Pass mark is set per sitting using Angoff standard-setting rather than a fixed percentage (24/40 in June 2025). A candidate must meet the pass mark for both Part 1 and Part 2 in the same sitting; compensation between parts is not allowed.

Exam Fee

Included in the GBP 182 Common Registration Assessment registration fee; the assessment may be sat a maximum of three times. (General Pharmaceutical Council (GPhC), UK)

GPhC CRA Part 1 (Calculations) Exam Content Outline

22%

Dose and dosage regimens

Weight-based and paediatric dosing, loading and maintenance doses, divided doses, maximum-dose checks, and opioid and insulin conversions.

15%

Concentrations

Percentage strengths (w/v and w/w), ratio strengths (1 in x), parts per million, millimoles, and mg/mL conversions.

12%

Infusion rates

mL/hour and drops/minute calculations, drop factors, weight-based and unit-based infusions, and infusion duration.

11%

Dilutions

C1V1 = C2V2 problems, serial and parts dilutions, mixing of products, and water-to-add calculations.

10%

Displacement volumes

Reconstitution of injectable powders, diluent and final volumes, and final concentrations using displacement values.

10%

Quantities to supply

Course quantities for tablets, liquids, creams, inhalers, eye drops and insulin, with whole-pack rounding and fingertip units.

Pharmacokinetics

Half-life, steady state, volume of distribution, clearance, bioavailability, and creatinine clearance via Cockcroft-Gault.

Medical statistics

Incidence, prevalence, absolute and relative risk reduction, and number needed to treat.

Pharmacoeconomics

Cost per unit and per dose, cost comparison and savings, and incremental cost-effectiveness ratios per QALY.

How to Pass the GPhC CRA Part 1 (Calculations) Exam

What You Need to Know

Passing score: Pass mark is set per sitting using Angoff standard-setting rather than a fixed percentage (24/40 in June 2025). A candidate must meet the pass mark for both Part 1 and Part 2 in the same sitting; compensation between parts is not allowed.
Assessment: Part 1 of the two-part Common Registration Assessment: 40 pharmacy and healthcare calculation questions with numerical free-entry responses; an approved calculator is permitted.
Time limit: 120 minutes (2 hours)
Exam fee: Included in the GBP 182 Common Registration Assessment registration fee; the assessment may be sat a maximum of three times.

Keys to Passing

Complete 500+ practice questions
Score 80%+ consistently before scheduling
Focus on highest-weighted sections
Use our AI tutor for tough concepts

GPhC CRA Part 1 (Calculations) Study Tips from Top Performers

1Practise every one of the nine official calculation types, because each Part 1 paper guarantees at least one question from each category - including the less familiar pharmacoeconomics and medical statistics.

2Build speed and accuracy with multi-step problems: convert units first, round only at appropriate stages, and become fluent with your approved calculator since you have roughly 3 minutes per question.

3Memorise the everyday formulae the GPhC expects you to know unaided (such as BMI, displacement adjustments and Cockcroft-Gault), and learn to read BNF and BNFC extracts quickly to extract the figures you need.

Frequently Asked Questions

How many questions are in GPhC CRA Part 1 and how long is it?

Part 1 has 40 pharmacy and healthcare calculation questions to be completed in 120 minutes (about 3 minutes per question). Answers are entered as numerical free text, and an approved calculator is permitted.

What is the pass mark for GPhC Part 1?

There is no fixed percentage pass mark. The GPhC sets the pass mark for each sitting using Angoff standard-setting based on question difficulty; for example, the Part 1 pass mark was 24 out of 40 in the June 2025 sitting. Part 1 and Part 2 must both be passed in the same sitting.

What types of calculations are tested in Part 1?

Each Part 1 paper includes at least one question from each of nine categories: concentrations, dilutions, displacement volumes, dose and dosage regimens, infusion rates, medical statistics, pharmacoeconomics, pharmacokinetics and quantities to supply.

Where and how is the assessment delivered?

The Common Registration Assessment is a computer-based exam delivered at UK test centres using the Surpass platform, jointly run by the GPhC and the Pharmaceutical Society Northern Ireland. It can be sat a maximum of three times within the registration time limit.