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100+ Free Psychiatry Shelf Practice Questions

Pass your NBME Clinical Science Subject Exam - Psychiatry exam on the first try — instant access, no signup required.

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A 26-year-old man with schizophrenia continues to have command auditory hallucinations despite adequate trials of risperidone and aripiprazole. He has no contraindication to blood monitoring. Which medication is most appropriate?

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2026 Statistics

Key Facts: Psychiatry Shelf Exam

110

Official NBME item count for Psychiatry

NBME Subject Examination Timing Chart

2:45

Official exam length

NBME Subject Examination Timing Chart

65%-70%

Behavioral Health systems weight

NBME Psychiatry Subject Exam Content Outline

30%-35%

Pharmacotherapy, intervention, and management task weight

NBME Psychiatry Subject Exam Content Outline

The Psychiatry shelf exam is a 110-item, 2 hour 45 minute NBME Clinical Science Subject Exam. NBME's public outline weights Behavioral Health at 65%-70%, diagnosis and foundational concepts at 65%-70% of physician tasks, and pharmacotherapy/intervention/management at 30%-35%. Passing thresholds and fees are institution-specific.

Sample Psychiatry Shelf Practice Questions

Try these sample questions to test your Psychiatry Shelf exam readiness. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.

1A 32-year-old intern has 5 weeks of depressed mood, anhedonia, early-morning awakening, poor concentration, guilt, low energy, and 12-lb weight loss. She has never had a manic or hypomanic episode and denies substance use. Which diagnosis is most likely?
A.Persistent depressive disorder
B.Major depressive disorder
C.Adjustment disorder with depressed mood
D.Bipolar II disorder
Explanation: Major depressive disorder requires at least 5 depressive symptoms for at least 2 weeks, including depressed mood or anhedonia, with impairment and no history of mania or hypomania.
2A 24-year-old man is brought to the emergency department after 8 days of sleeping 2 hours nightly, talking rapidly, spending thousands of dollars, and believing he has been chosen to advise the president. He is hospitalized for unsafe behavior. Which diagnosis is most appropriate?
A.Cyclothymic disorder
B.Bipolar II disorder
C.Bipolar I disorder
D.Substance-induced depressive disorder
Explanation: Bipolar I disorder is diagnosed after any manic episode lasting at least 1 week or requiring hospitalization. Grandiosity, decreased need for sleep, pressured speech, and dangerous spending are classic manic symptoms.
3A 29-year-old woman with recurrent depressive episodes describes a 5-day period last year when she felt unusually energetic, needed little sleep, was more talkative, and started several projects. Friends noticed the change, but she was not psychotic, hospitalized, or severely impaired. What is the best diagnosis?
A.Bipolar II disorder
B.Bipolar I disorder
C.Cyclothymic disorder
D.Borderline personality disorder
Explanation: Bipolar II disorder requires at least one hypomanic episode and one major depressive episode. Hypomania lasts at least 4 days and is observable but does not cause marked impairment, psychosis, or hospitalization.
4A 41-year-old man says he has felt down most days for 3 years with low self-esteem, fatigue, and poor concentration. He continues to work and has never had 2 months fully symptom-free. He has no history of mania. Which diagnosis best fits?
A.Persistent depressive disorder
B.Major depressive disorder with psychotic features
C.Cyclothymic disorder
D.Normal bereavement
Explanation: Persistent depressive disorder is chronic depressed mood for at least 2 years in adults plus associated symptoms such as low energy, low self-esteem, poor concentration, appetite or sleep changes, or hopelessness.
5A 30-year-old woman 6 days after delivery has not slept, says the baby is possessed, and tries to leave the nursery to protect the infant from imaginary attackers. She has a history of bipolar I disorder. What is the next step?
A.Schedule outpatient psychotherapy within 1 week
B.Reassure her that intrusive thoughts are common after delivery
C.Hospitalize her urgently and start treatment for postpartum psychosis
D.Start buspirone and discharge with family supervision
Explanation: Postpartum psychosis is a psychiatric emergency, especially with bipolar history, delusions, insomnia, and risk to the infant. Urgent hospitalization and antipsychotic or mood-stabilizing treatment are indicated.
6A 45-year-old man with severe major depression refuses food because he believes his intestines have stopped working and says he plans to die today. Which treatment is most appropriate in addition to safety measures?
A.Electroconvulsive therapy
B.Weekly supportive psychotherapy alone
C.Light therapy only
D.Methylphenidate monotherapy
Explanation: ECT is appropriate for severe depression with psychotic features, suicidality, refusal of food or fluids, catatonia, or need for rapid response.
7A 23-year-old graduate student has her first episode of moderate major depression without psychosis, mania, substance use, pregnancy, or acute suicidality. Which initial pharmacotherapy is most appropriate?
A.Sertraline
B.Haloperidol
C.Lithium monotherapy
D.Diazepam
Explanation: SSRIs such as sertraline are first-line medications for uncomplicated major depressive disorder and are commonly paired with psychotherapy.
8A 27-year-old woman with bipolar depression asks for a medication with relatively favorable reproductive safety compared with valproate. She is not acutely manic and has no rash history. Which option is most appropriate for bipolar depression maintenance?
A.Lamotrigine
B.Fluoxetine monotherapy
C.Tranylcypromine
D.Alprazolam
Explanation: Lamotrigine is useful for bipolar depression and maintenance, has lower teratogenic risk than valproate, and must be titrated slowly to reduce serious rash risk.
9A 38-year-old man taking lithium develops vomiting, diarrhea, coarse tremor, confusion, and ataxia after starting ibuprofen for back pain. His lithium level is 2.3 mEq/L. What is the best next step?
A.Continue lithium and add propranolol
B.Hold lithium, give isotonic IV fluids, and consider hemodialysis
C.Increase lithium because symptoms suggest relapse
D.Add hydrochlorothiazide to increase lithium clearance
Explanation: Lithium toxicity with neurologic findings requires stopping lithium, volume resuscitation, medication review, and nephrology consultation for possible hemodialysis depending on level, symptoms, and renal function.
10A woman with bipolar I disorder who is planning pregnancy asks which mood stabilizer should generally be avoided because of neural tube defects and adverse neurodevelopmental outcomes. Which medication is the concern?
A.Lamotrigine
B.Valproate
C.Sertraline
D.Quetiapine
Explanation: Valproate is highly teratogenic, associated with neural tube defects and neurodevelopmental harm, and should generally be avoided in pregnancy when alternatives exist.

About the Psychiatry Shelf Exam

The NBME Psychiatry Clinical Science Subject Exam is a secure end-of-clerkship assessment used by medical schools to evaluate knowledge and clinical reasoning in psychiatry. The public NBME outline emphasizes behavioral health, diagnosis, pharmacotherapy, intervention, and management across ambulatory, emergency, and inpatient settings. Students should be ready for clinical vignettes on mood, anxiety, trauma, psychotic, substance use, personality, somatic symptom, eating, sleep, neurocognitive, child and adolescent, emergency, and ethics or legal topics.

Assessment

110 one-best-answer multiple-choice clinical vignette items

Time Limit

2 hours, 45 minutes

Passing Score

Set locally by the medical school or clerkship using NBME equated scores and norms

Exam Fee

Varies by institution; usually ordered through the medical school (National Board of Medical Examiners (NBME))

Psychiatry Shelf Exam Content Outline

65%-70%

Behavioral Health Core

Mood, psychotic, anxiety, trauma, somatic symptom, factitious, eating, childhood-onset, personality, psychosocial, substance use, and medication adverse-effect topics.

65%-70% of physician task

Diagnosis and Clinical Reasoning

DSM-5-TR criteria, differential diagnosis, mental status findings, medical mimics, risk assessment, and selecting the most likely diagnosis from vignettes.

30%-35% of physician task

Treatment and Management

Medication selection, psychotherapy, acute stabilization, hospitalization decisions, monitoring, medication adverse effects, and follow-up planning.

10%-15%

Neurocognitive and Neurologic Psychiatry

Delirium, Alzheimer disease, dementia with Lewy bodies, frontotemporal and vascular dementia, sleep disorders, movement disorders, seizures, and neurologic causes of psychiatric symptoms.

20%-30% ED site of care

Emergency Psychiatry

Suicide and violence risk, agitation, intoxication, withdrawal, catatonia, serotonin syndrome, neuroleptic malignant syndrome, involuntary commitment, and safety planning.

1%-5%

Ethics, Legal, and Communication

Capacity, confidentiality, minor consent, mandated reporting, duty to protect, informed consent, therapeutic boundaries, motivational interviewing, and patient-centered communication.

10%-15% birth to 12 years

Child and Adolescent Psychiatry

ADHD, autism spectrum disorder, tic disorders, enuresis, disruptive behavior disorders, separation anxiety, pediatric depression, eating disorders, and developmental considerations.

5%-10% other systems

Medical and Multisystem Interfaces

Endocrine, neurologic, pregnancy/postpartum, nutritional, medication-induced, and substance-induced causes of psychiatric presentations.

How to Pass the Psychiatry Shelf Exam

What You Need to Know

  • Passing score: Set locally by the medical school or clerkship using NBME equated scores and norms
  • Assessment: 110 one-best-answer multiple-choice clinical vignette items
  • Time limit: 2 hours, 45 minutes
  • Exam fee: Varies by institution; usually ordered through the medical school

Keys to Passing

  • Complete 500+ practice questions
  • Score 80%+ consistently before scheduling
  • Focus on highest-weighted sections
  • Use our AI tutor for tough concepts

Psychiatry Shelf Study Tips from Top Performers

1Tie every diagnosis to a duration, impairment threshold, exclusion, and key distinguishing feature.
2For mood questions, always screen for past mania or hypomania before choosing antidepressant monotherapy.
3Memorize emergency syndromes: serotonin syndrome, neuroleptic malignant syndrome, lithium toxicity, alcohol withdrawal, opioid overdose, and catatonia.
4Know first-line treatments: SSRIs for depression and many anxiety disorders, ERP for OCD, trauma-focused therapy for PTSD, stimulants for school-age ADHD, and CBT-I for chronic insomnia.
5For psychosis, use duration to separate brief psychotic disorder, schizophreniform disorder, schizophrenia, mood disorder with psychotic features, and schizoaffective disorder.
6Review antipsychotic adverse effects, including acute dystonia, akathisia, parkinsonism, tardive dyskinesia, metabolic syndrome, clozapine agranulocytosis, and myocarditis.
7Use safety first in emergency psychiatry: assess plan, intent, means, intoxication, psychosis, supports, prior attempts, and ability to collaborate on safety.
8Capacity questions require understanding, appreciation, reasoning, and communication of a choice; psychiatric diagnosis alone does not remove capacity.
9For neurocognitive cases, separate delirium from dementia by acute fluctuating attention impairment versus chronic progressive decline.
10Practice with timed clinical vignettes because the shelf rewards fast recognition of the decisive clue and the safest next step.

Frequently Asked Questions

How many questions are on the NBME Psychiatry shelf exam?

The NBME Subject Examination Timing Chart lists Psychiatry as 110 items with an exam length of 2 hours and 45 minutes.

What content is emphasized on the Psychiatry Clinical Science Subject Exam?

NBME's public Psychiatry outline lists Behavioral Health as 65%-70% of systems content, with diagnosis and foundational concepts 65%-70% of physician tasks and pharmacotherapy, intervention, and management 30%-35%.

Is there one national passing score for the Psychiatry shelf?

No single public national passing cutoff applies to all students. NBME provides equated scores, norms, and grading guidance, while each medical school or clerkship sets local grading thresholds.

What question style should I expect?

Expect one-best-answer clinical vignettes that ask for diagnosis, next best step, treatment selection, adverse effect recognition, risk assessment, or an ethics/legal action.

How should I study in the last week?

Do mixed timed sets, review missed questions by diagnosis and management principle, memorize high-yield adverse effects and emergencies, and practice pacing close to 1.5 minutes per item.