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100+ Free SMC Qualifying Exam Practice Questions

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Key Facts: SMC Qualifying Exam Exam

The SMC Qualifying Examination is a two-part statutory exam (Written MCQ + Clinical OSCE) for overseas medical graduates seeking conditional registration in Singapore. Administered by NUS on behalf of the Singapore Medical Council, it is benchmarked to the NUS final MBBS standard and covers six core disciplines: internal medicine, surgery, obstetrics and gynaecology, paediatrics, psychiatry, and community medicine. Candidates must hold an overseas medical degree and obtain SMC approval before sitting the examination. The registration application fee is S$300 and the annual Practising Certificate costs S$550.

Sample SMC Qualifying Exam Practice Questions

Try these sample questions to test your SMC Qualifying Exam exam readiness. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.

1A 55-year-old man presents to a polyclinic with exertional chest tightness for the past 2 weeks. The pain is substernal, radiates to the left arm, and is relieved by rest within 5 minutes. His ECG shows ST depression in leads V4-V6 during a treadmill stress test. What is the most likely diagnosis?
A.Stable angina pectoris
B.Unstable angina
C.Acute ST-elevation myocardial infarction
D.Prinzmetal (variant) angina
Explanation: Stable angina presents as predictable exertional chest pain that is relieved by rest, typically lasting less than 10 minutes. The ST depression on stress testing confirms inducible myocardial ischaemia. Unstable angina would present with pain at rest or a crescendo pattern, while STEMI shows ST elevation rather than depression.
2A 68-year-old woman with a history of hypertension and diabetes presents with sudden onset breathlessness and bilateral leg oedema. On examination, she has elevated JVP, bibasal crepitations, and a third heart sound (S3). Her chest X-ray shows bilateral pulmonary oedema. What is the most appropriate initial management?
A.Intravenous furosemide with supplemental oxygen
B.Oral amlodipine
C.Immediate coronary angiography
D.Intravenous normal saline bolus
Explanation: This patient is in acute decompensated heart failure with pulmonary oedema. The immediate priorities are reducing preload with IV loop diuretics (furosemide) and maintaining oxygenation. The S3 gallop, elevated JVP, bilateral crepitations, and peripheral oedema are classic signs of congestive cardiac failure.
3A 45-year-old man presents to the emergency department with sudden onset palpitations and dizziness. His ECG shows a narrow complex tachycardia at 180 bpm with no visible P waves. Carotid sinus massage transiently slows the rate before it abruptly terminates. What is the most likely arrhythmia?
A.Atrial fibrillation
B.Atrioventricular nodal re-entrant tachycardia (AVNRT)
C.Atrial flutter with 2:1 block
D.Ventricular tachycardia
Explanation: AVNRT is the most common regular narrow complex supraventricular tachycardia. It typically presents with abrupt onset and termination, absent visible P waves (buried in QRS), and responds to vagal manoeuvres or adenosine by abruptly terminating the circuit. The re-entrant circuit involves dual AV nodal pathways.
4A 60-year-old smoker presents with a 3-month history of progressive breathlessness. Spirometry shows FEV1/FVC ratio of 0.55 with minimal bronchodilator reversibility. His chest X-ray shows hyperinflated lungs and flattened diaphragms. What is the most likely diagnosis?
A.Bronchial asthma
B.Chronic obstructive pulmonary disease
C.Idiopathic pulmonary fibrosis
D.Bronchiectasis
Explanation: COPD is characterised by persistent airflow limitation that is not fully reversible, typically in patients with significant smoking history. The FEV1/FVC ratio below 0.70 post-bronchodilator confirms obstructive airways disease, and the minimal reversibility distinguishes it from asthma. Hyperinflated lungs and flattened diaphragms on CXR support the diagnosis.
5A 30-year-old woman presents with a 2-day history of right-sided pleuritic chest pain and breathlessness. She is on combined oral contraceptive pills. Her D-dimer is elevated and CT pulmonary angiography reveals a filling defect in the right lower lobe pulmonary artery. What is the most appropriate next step in management?
A.Start therapeutic anticoagulation with low-molecular-weight heparin
B.Prescribe antibiotics for pneumonia
C.Arrange outpatient spirometry in 2 weeks
D.Perform surgical embolectomy immediately
Explanation: This patient has a confirmed pulmonary embolism (PE) on CTPA. Combined oral contraceptives are a well-established risk factor for venous thromboembolism. Therapeutic anticoagulation with LMWH (or unfractionated heparin) should be initiated immediately, followed by transition to oral anticoagulant therapy. The OCP should be discontinued.
6A 50-year-old man presents with recurrent epigastric pain that worsens after meals. Upper GI endoscopy reveals a gastric ulcer on the lesser curvature. Biopsy shows Helicobacter pylori infection. What is the most appropriate treatment?
A.Proton pump inhibitor (PPI) monotherapy for 8 weeks
B.Triple therapy: PPI plus amoxicillin plus clarithromycin
C.Surgical vagotomy with antrectomy
D.Antacid therapy alone
Explanation: H. pylori eradication is the cornerstone of treatment for peptic ulcer disease associated with H. pylori infection. Standard triple therapy consists of a PPI with two antibiotics (typically amoxicillin and clarithromycin) for 14 days. Eradication dramatically reduces ulcer recurrence rates and should be confirmed post-treatment.
7A 40-year-old Chinese man presents with a 6-month history of intermittent bloody diarrhoea, abdominal cramping, and tenesmus. Colonoscopy reveals continuous mucosal inflammation extending from the rectum to the splenic flexure with pseudopolyps. What is the most likely diagnosis?
A.Crohn disease
B.Ulcerative colitis
C.Colorectal carcinoma
D.Amoebic colitis
Explanation: Ulcerative colitis characteristically affects the rectum and extends proximally in a continuous pattern. Key features include bloody diarrhoea, tenesmus, and continuous mucosal inflammation with pseudopolyps on colonoscopy. Unlike Crohn disease, it is limited to the mucosa and submucosa and does not produce skip lesions or transmural inflammation.
8A 52-year-old woman with poorly controlled type 2 diabetes mellitus has an HbA1c of 9.5% despite maximum-dose metformin. Her estimated GFR is 65 mL/min/1.73m². She has a BMI of 34 kg/m² and a history of atherosclerotic cardiovascular disease. Which add-on agent provides the greatest cardiovascular benefit?
A.Glipizide (sulphonylurea)
B.Empagliflozin (SGLT2 inhibitor)
C.Acarbose (alpha-glucosidase inhibitor)
D.Pioglitazone (thiazolidinedione)
Explanation: SGLT2 inhibitors such as empagliflozin have demonstrated significant reduction in cardiovascular mortality and heart failure hospitalisation in large outcome trials (EMPA-REG OUTCOME). They also offer renal protection and modest weight loss, making them particularly suitable for obese patients with established cardiovascular disease.
9A 35-year-old woman presents with weight loss, heat intolerance, tremor, and a diffusely enlarged thyroid gland. Blood tests show suppressed TSH and elevated free T4. What investigation would best confirm the aetiology?
A.Fine needle aspiration cytology of the thyroid
B.Thyroid-stimulating hormone receptor antibodies (TRAb)
C.Serum calcitonin level
D.CT scan of the neck
Explanation: The clinical features and biochemistry suggest thyrotoxicosis, and the diffuse goitre points to Graves disease as the most likely cause. TRAb (also known as TSI) is highly specific for Graves disease and confirms the autoimmune aetiology. It distinguishes Graves disease from toxic multinodular goitre and thyroiditis.
10A 58-year-old man with chronic kidney disease stage 4 (eGFR 22 mL/min/1.73m²) presents with fatigue, pallor, and a normocytic normochromic anaemia (Hb 8.5 g/dL). Iron studies are normal. What is the most likely cause of his anaemia?
A.Iron deficiency anaemia
B.Erythropoietin deficiency due to renal failure
C.Vitamin B12 deficiency
D.Myelodysplastic syndrome
Explanation: Anaemia of chronic kidney disease is primarily caused by reduced erythropoietin production by the failing kidneys. It typically presents as a normocytic normochromic anaemia with normal iron studies. Erythropoiesis-stimulating agents (ESAs) are the mainstay of treatment once iron stores are confirmed adequate.

About the SMC Qualifying Exam Practice Questions

Verified exam format metadata for Singapore Medical Council Qualifying Examination is pending. The practice questions above remain available while official exam length, timing, passing score, fee, and administrator details are reviewed.