Free Practice Questions for Morocco Pharmacy Residency Exam

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Key Facts: Morocco Pharmacy Residency Exam Exam

4 written papers

Written admissibility examinations covering Fundamental Sciences, Drug Sciences I & II, and Clinical Biology

Facultés de Médecine et de Pharmacie du Maroc official regulations

Jury-set threshold

The jury determines the minimum admissibility mark; no fixed national pass mark is stated

Arrêté conjoint n° 2116-95, Article 10

4 attempt limit

Maximum allowable lifetime sittings under national university training statutes

Arrêté conjoint n° 2116-95, Article 1

Loi 17-04

Moroccan national legal framework governing pharmaceutical practice, drugs, and poison scheduling

Code du Médicament et de la Pharmacie (Bulletin Officiel)

2 hours each

Each admissibility composition has at least four questions and lasts two hours

Arrêté conjoint n° 2116-95, Article 9

A free 100-question English MCQ practice bank for Morocco's Concours de Résidanat en Pharmacie. It covers basic sciences, medicinal chemistry, galenics, pharmacology, toxicology, pharmacy legislation, and clinical biology for Moroccan pharmacy residency preparation.

Sample Morocco Pharmacy Residency Exam Practice Questions

Try these sample questions to review concepts for the Morocco Pharmacy Residency Exam exam. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.

1According to the Beer-Lambert law (A = epsilon * c * l) utilized in pharmaceutical UV-visible spectrophotometric assays, what is the mathematical relationship between absorbance (A) and percent transmittance (%T)?

A.A = 2 - log10(%T)

B.A = log10(%T) - 2

C.A = 100 / %T

D.A = -ln(%T / 10)

Explanation: Transmittance T is defined as I / I0, and percent transmittance is %T = 100 * (I / I0). Absorbance is defined as A = -log10(T) = -log10(%T / 100) = log10(100) - log10(%T) = 2 - log10(%T). This fundamental equation allows spectrophotometers to convert measured transmitted light directly into linear absorbance values.

2In pharmaceutical analytical chemistry, which chromatographic parameter directly measures the efficiency of a high-performance liquid chromatography (HPLC) column in terms of theoretical plate count (N)?

A.N = 16 * (tR / W)^2

B.N = (tR2 - tR1) / W

C.N = tR * k'

D.N = alpha / (1 - alpha)

Explanation: Theoretical plate count (N), a fundamental index of chromatographic column efficiency, is calculated from the retention time (tR) and baseline peak width (W) by the equation N = 16 * (tR / W)^2, or alternatively N = 5.545 * (tR / W0.5)^2 using peak width at half-height (W0.5). A higher number of theoretical plates indicates sharper peaks and superior column efficiency.

3In reversed-phase high-performance liquid chromatography (RP-HPLC), what is the typical nature of the stationary phase and mobile phase, and what is the elution order of analytes?

A.Non-polar hydrophobic stationary phase (e.g., C18 octadecylsilyl) and polar aqueous-organic mobile phase; polar analytes elute first, followed by lipophilic analytes

B.Polar hydrophilic stationary phase (e.g., unmodified silica) and non-polar organic mobile phase; lipophilic analytes elute first

C.Ion-exchange resin stationary phase with a pure non-polar mobile phase; neutral compounds elute last

D.Immobilized chiral stationary phase with supercritical CO2; racemic enantiomers elute simultaneously

Explanation: In reversed-phase HPLC (RP-HPLC), the stationary phase is non-polar and hydrophobic (most commonly bonded silica functionalized with octadecyl hydrocarbon chains, C18 or C8), while the mobile phase is polar (a mixture of water/buffer and organic modifiers such as acetonitrile or methanol). Consequently, polar solutes have lower affinity for the stationary phase and elute first, whereas lipophilic solutes partition strongly into the non-polar chains and elute later.

4During a compendial non-aqueous acid-base titration of a weak organic basic drug such as codeine or diazepam, which solvent and standard titrant are classically selected?

A.Glacial acetic acid (acide acétique glacial) as solvent and perchloric acid (acide perchlorique, HClO4) in glacial acetic acid as titrant

B.Distilled water as solvent and standardized sodium hydroxide (NaOH) as titrant

C.Liquid ammonia as solvent and hydrochloric acid (HCl) as titrant

D.Pure chloroform as solvent and sulfuric acid (H2SO4) in ethanol as titrant

Explanation: Weak organic bases with pKa < 4 cannot be accurately titrated in aqueous medium due to the leveling effect and basicity of water. Non-aqueous titration in glacial acetic acid (an acidic protogenic solvent that enhances the basicity of weak bases) titrated with perchloric acid (HClO4, the strongest known protic acid in glacial acetic acid) generates sharp potentiometric or visual (crystal violet indicator) endpoints.

5What is the Henderson-Hasselbalch equation used to calculate the pH of an aqueous buffer solution composed of a weak acid (HA) and its conjugate base (A-)?

A.pH = pKa + log10([A-] / [HA])

B.pH = pKa - log10([A-] / [HA])

C.pH = pKa * ([A-] / [HA])

D.pH = 14 - pKa + log10([HA] / [A-])

Explanation: The Henderson-Hasselbalch equation is derived from the acid dissociation constant Ka = ([H+][A-]) / [HA]. Taking the negative base-10 logarithm yields -log[H+] = -log(Ka) - log([HA] / [A-]), which simplifies to pH = pKa + log10([A-] / [HA]). Maximum buffering capacity occurs when [A-] = [HA], at which point pH = pKa.

6In nuclear magnetic resonance (1H-NMR) spectroscopy, what structural information is provided by the spin-spin coupling constant (J value, expressed in Hertz)?

A.The spatial and dihedral angle relationship (Karplus relationship) and number of bonds separating interacting non-equivalent neighboring nuclei, independent of magnetic field strength

B.The total absolute number of protons present in the molecule

C.The exact molecular weight and elemental composition of the unknown fragment

D.The electron density and chemical shielding tensor dependent directly on spectrometer field frequency

Explanation: The coupling constant (J, in Hz) represents the scalar interaction through chemical bonds between nuclear magnetic spins of non-equivalent neighboring protons. Crucially, J is strictly independent of the applied external magnetic field strength (unlike chemical shift delta in Hz, which scales with field frequency) and its magnitude depends on the dihedral bond angle theta (as modeled by the Karplus equation), revealing stereochemical orientation (e.g., trans vs. cis J couplings).

7In pharmaceutical mass spectrometry (MS), which ionization technique operates under atmospheric pressure, generates quasimolecular ions ([M+H]+ or [M-H]-) with minimal fragmentation ('soft ionization'), and is ideally suited for liquid chromatography coupling (LC-MS) of polar, thermolabile macromolecular pharmaceuticals?

A.Electrospray ionization (ESI)

B.Electron impact ionization (EI at 70 eV)

C.Fast atom bombardment (FAB)

D.Inductively coupled plasma ionization (ICP)

Explanation: Electrospray ionization is an atmospheric-pressure soft-ionization technique in which a liquid analyte solution is sprayed through a high-voltage capillary to produce charged droplets. Solvent evaporation and Coulombic fission release often multiply charged quasimolecular ions with limited fragmentation, making ESI well suited to LC-MS analysis of polar and thermally labile drugs, peptides, and proteins.

8In the Michaelis-Menten kinetic model of single-substrate enzymatic reactions (v = (Vmax * [S]) / (Km + [S])), how is the Michaelis constant (Km) biochemically defined?

A.The substrate concentration [S] at which the initial reaction velocity reaches half of the maximum velocity (Vmax / 2)

B.The maximum rate of catalysis when the enzyme active sites are completely saturated

C.The reciprocal of the catalytic turnover number (1 / kcat)

D.The equilibrium association constant for enzyme-inhibitor complex formation

Explanation: The Michaelis constant (Km) is operationally defined as the substrate concentration at which reaction rate is exactly half of Vmax. When [S] = Km, the equation becomes v = (Vmax * Km) / (2 * Km) = Vmax / 2. Km reflects the affinity of the enzyme for its substrate under Briggs-Haldane steady-state assumptions: a smaller Km indicates higher apparent substrate affinity.

9How does a classic competitive enzyme inhibitor alter the apparent Michaelis constant (Km) and maximum velocity (Vmax) in Lineweaver-Burk double-reciprocal plots (1/v versus 1/[S])?

A.Km is increased (apparent affinity decreased) while Vmax remains unchanged

B.Vmax is decreased while Km remains unchanged

C.Both Km and Vmax are decreased by an identical factor (parallel lines)

D.Both Km and Vmax are increased proportionally

Explanation: A competitive inhibitor binds reversibly to the free enzyme active site, directly competing with the substrate. High concentrations of substrate can displace the inhibitor, meaning that maximum velocity (Vmax) remains achievable and unchanged. However, higher substrate concentrations are required to reach half-maximal velocity, causing an apparent increase in Km (1/Km intercept moves closer to zero on Lineweaver-Burk plot).

10In the citric acid cycle (Krebs cycle), which mitochondrial enzyme catalyzes the only reaction that directly couples substrate-level phosphorylation to the generation of a high-energy nucleoside triphosphate (GTP or ATP)?

A.Succinyl-CoA synthetase (succinate thiokinase)

B.Citrate synthase

C.Isocitrate dehydrogenase

D.Malate dehydrogenase

Explanation: Succinyl-CoA synthetase (also called succinate thiokinase) cleaves the high-energy thioester bond of succinyl-CoA to produce succinate and coenzyme A-SH, coupling this exergonic cleavage to the phosphorylation of GDP to GTP (or ADP to ATP in certain tissues) by substrate-level phosphorylation. This is the sole substrate-level phosphorylation step within the Krebs cycle.

About the Morocco Pharmacy Residency Exam Exam

The Concours de Résidanat en Pharmacie is a faculty-organized Moroccan postgraduate competition for doctors of pharmacy seeking specialty training. The official assessment uses written compositions in pharmaceutical sciences and clinical biology. This 100-question English MCQ bank is independent study practice, not an official translation or format simulation and not a substitute for written-response practice.

Exam sponsor: Facultés de Médecine et de Pharmacie du Maroc under the Ministère de la Santé et de la Protection Sociale and Ministère de l'Enseignement Supérieur. The requirements and fees below concern the certification or admission exam, separate from our free practice resources.

Assessment

Two written stages: admissibility combines the épreuve des titres (coefficient 2) with four equal-coefficient written compositions in Fundamental Sciences, Drug Sciences I, Drug Sciences II, and Clinical Biology. Definitive admission contains four equal-coefficient compositions across two Drug Sciences and two Clinical Biology groups.

Time Limit

Two hours for each admissibility composition; two hours total for the definitive-admission written stage

Passing Score

The jury sets the minimum admissibility mark; the governing regulation does not publish a fixed universal pass mark. Final admission is ranked using results from both stages.

Exam / Certification Fees

100 MAD dossier fee in the Rabat faculty's 2026 notice; verify the current organizing-faculty notice

Exam sponsor website

Fees, eligibility, and exam policies can change. Confirm them with the exam sponsor before applying or paying.

Official sources

Our practice resources: topics covered

We aim to reflect publicly available exam outlines and topic information in our study resources. Coverage, format, and difficulty may differ from the actual exam, and we cannot guarantee that every detail is accurate or current. Confirm exam requirements, fees, and policies with the official exam sponsor.

25%

Sciences Fondamentales

Analytical chemistry, chromatography and spectroscopy, physical chemistry, structural biochemistry, and pharmaceutical statistics.

25%

Sciences du Médicament I

Therapeutic chemistry, structure-activity relationships, pharmacognosy, plant natural products, and industrial pharmaceutical galenics.

25%

Sciences du Médicament II

Systemic pharmacology, mechanism-based therapeutics, clinical toxicology, antidotes, and Moroccan pharmaceutical legislation (Loi 17-04).

25%

Biologie Clinique

Biological hematology, hemostasis, medical bacteriology, virology, clinical biochemistry, and diagnostic immunology.

Preparing for the Morocco Pharmacy Residency Exam Exam

What You Need to Know

Passing score: The jury sets the minimum admissibility mark; the governing regulation does not publish a fixed universal pass mark. Final admission is ranked using results from both stages.
Assessment: Two written stages: admissibility combines the épreuve des titres (coefficient 2) with four equal-coefficient written compositions in Fundamental Sciences, Drug Sciences I, Drug Sciences II, and Clinical Biology. Definitive admission contains four equal-coefficient compositions across two Drug Sciences and two Clinical Biology groups.
Time limit: Two hours for each admissibility composition; two hours total for the definitive-admission written stage
Exam / certification fees: 100 MAD dossier fee in the Rabat faculty's 2026 notice; verify the current organizing-faculty notice Official sources

Using Our Practice Resources

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Morocco Pharmacy Residency Exam: Suggested Study Strategy

1Master analytical instrumentation: principles of HPLC, gas chromatography, mass spectrometry, UV-visible spectrophotometry, and acid-base potentiometric titrations.

2Thoroughly review medicinal chemistry structure-activity relationships (SAR) for major therapeutic classes: beta-lactams, quinolones, statins, ACE inhibitors, and NSAIDs.

3Understand galenical formulation science: bioavailability, dissolution kinetics, tablet excipients, sterile injectable preparation, and modified-release dosage forms.

4Memorize key toxicology antidotes and intoxication syndromes: paracetamol (N-acetylcysteine), organophosphates (atropine/pralidoxime), carbon monoxide, and digoxin (DigiFab).

5Master Moroccan pharmacy law (Loi 17-04): classification of scheduled poisons (Tableau A, B, C), marketing authorization (AMM) requirements, and dispensary ownership rules.

Frequently Asked Questions

What is Morocco's Concours de Résidanat en Pharmacie?

It is a competitive postgraduate examination organized by Moroccan university faculties of medicine and pharmacy that qualifies and ranks doctors of pharmacy for hospital residency positions and specialized post-graduate diplomas (DES).

What are the four written papers in the Moroccan pharmacy residency competition?

Candidates sit four written papers: Sciences fondamentales (coeff 1), Sciences du médicament I (coeff 1: chimie thérapeutique, pharmacognosie, galénique), Sciences du médicament II (coeff 1: pharmacologie, toxicologie, législation pharmaceutique), and Biologie clinique (coeff 1: hématologie, bactériologie, biochimie clinique).

What is the qualifying passing score?

Arrêté conjoint n° 2116-95 does not publish a fixed universal pass mark. The jury sets the minimum admissibility mark, and definitive admission is determined by merit ranking across the written stages.

How many times may a candidate sit the pharmacy residency exam?

Under Moroccan regulations governing postgraduate health sciences training, a doctor of pharmacy is permitted a maximum of four (4) attempts.

How does this practice bank differ from the official assessment?

The official notices and programs reviewed are published in French, but they do not separately state the permitted response language. The official assessment uses written compositions. This bank uses English four-option MCQs as independent study practice, not as an official translation or format simulation.