A 70-year-old female presents with severe right upper quadrant pain, high fever (39.0 C), confusion, and hypotension (BP 85/50 mmHg). Labs reveal elevated bilirubin and leukocytosis. Right upper quadrant ultrasound shows a distended gallbladder with stones, gallbladder wall thickening (5 mm), and a sonographic Murphy's sign. According to the Tokyo Guidelines 2018 (TG18), what is the severity grade of her acute cholecystitis, and what is the most appropriate initial management?
- AGrade I (Mild); Early laparoscopic cholecystectomy
- BGrade II (Moderate); Delayed laparoscopic cholecystectomy after 6 weeks
- CGrade III (Severe); Urgent percutaneous cholecystostomy tube drainage and stabilization
- DGrade III (Severe); Immediate emergency open cholecystectomy