Cheat sheet

a-IPC Cheat Sheet

Quick Facts

Exam
a-IPC (CBIC)
Items
100 total, 85 scored
Pretest
15 unscored items
Testing time
2 hours
Appointment
2.5 hours total
Pass
700 scaled (300-900)
Score report
Pass = no number
Fee
$335 USD
Pass rate
63% (2025 testers)
Navigation
Forward-only, no review
Delivery
Prometric or ProProctor
Eligibility
None required
Valid
Five years
Retake
Once every six months
Blueprint
Effective May 2026

Chain of Infection

Agent | Reservoir | Exit | Mode | Entry | Host

Break one linkHand hygiene = modeVaccine = hostReprocessing = reservoir

Colonization vs Infection

Colonization

  • Organism present
  • No tissue damage
  • Usually not treated

Infection

  • Tissue damage
  • Clinical signs present
  • Counted in surveillance

Presence vs harm

Chain of Infection

Infectious agent
The pathogen itself
Reservoir
Where the agent lives
Portal of exit
How it leaves
Mode of transmission
How it travels
Portal of entry
How it enters
Susceptible host
Who it infects
Break any link
Transmission stopsRule
Hand hygiene breaks
Mode of transmission
Vaccination breaks
Susceptible host

Prophylactic vs Empiric

Prophylactic

  • Before infection exists
  • Preoperative dosing
  • Prevention goal

Empiric

  • Infection suspected
  • Cultures pending
  • Guided by antibiogram

Prevent vs treat blind

Infection Status Terms

Colonization
Present, no tissue damage
Infection
Damage plus clinical response
Contamination
Organism on surface/specimen
Pseudo-infection
False positive, no disease
Pseudo-outbreak
Cluster of pseudo-infections
Incubation period
Exposure to symptom onset
Communicable period
When spread is possible
Only infections count
Colonization is excludedTrap

Lab and Diagnostic Signals

Gram stain
Minutes, presumptive only
Culture + AST
Days, gives susceptibility
MALDI-TOF
Rapid organism identification
Multiplex PCR
Hours, detects nucleic acid
Whole genome sequencing
Confirms outbreak relatedness
Antibiogram
Facility susceptibility summary
Leukocytosis + left shift
Suggests bacterial infection
Fever threshold
NHSN uses >38.0°C
Read susceptibility panel
Not organism name alone

Antimicrobial Use Categories

Prophylactic
Given before infection occurs
Empiric
Before cultures return
Therapeutic/definitive
Organism and susceptibility known
Surgical prophylaxis timing
Within 60 min before incision
Vancomycin/fluoroquinolone window
120 minutes before incision
After wound closure
No additional doses
De-escalation
Narrow after culture results

Host Risk Factors

Extremes of age
Neonates and elderly
Neutropenia
Low neutrophil defense
Transplant/chemotherapy
Drug-induced immunosuppression
Chronic corticosteroids
Blunted inflammatory response
Indwelling devices
Bypass skin barrier
Recent surgery
Breached tissue planes
Prior antimicrobials
Selects resistant flora
Travel + exposure history
Shapes plausible pathogens

Alert Organisms

MRSA
Methicillin-resistant Staphylococcus aureus
VRE
Vancomycin-resistant Enterococcus
CRE
Carbapenem-resistant Enterobacterales
C. difficile
Spore-forming, toxin-mediated colitis
Candida auris
Multidrug-resistant, environmentally persistent yeast
M. tuberculosis
Airborne, requires AIIR
Legionella pneumophila
Water system pathogen
Aspergillus fumigatus
Construction dust mold
Norovirus
Alcohol-resistant, explosive gastroenteritis

Outbreak Order

Verify | Define | Find | Describe | Hypothesize | Control | Report

Control can start earlyDefinition before case findingTime, place, person

Incidence vs Prevalence

Incidence

  • New cases only
  • Measures risk
  • Needs a period

Prevalence

  • New plus existing
  • Measures burden
  • Point in time

Risk vs burden

Rate Picker

  1. New cases over periodIncidence
  2. All cases at oncePrevalence
  3. Outbreak among exposedAttack rate(Times 100)
  4. Comparing device infectionsRate per 1,000 device-days
  5. Comparing surgical infectionsRate per 100 procedures
  6. Measuring device exposureDevice utilization ratio
  7. Comparing to national baselineSIR(Risk-adjusted)
  8. Predicted below 1.0Rates instead(No SIR calculated)

Epidemiology Formulas

Incidence
New cases / population at risk
Prevalence
All cases / population, point
Attack rate
Ill / at risk x 100
Device-associated rate
Infections / device-days x 1,000
SSI rate
SSIs / procedures x 100
DUR
Device-days / patient-days
SIR
Observed / predicted infections
SUR
Observed / predicted device-days
SIR floor rule
Not calculated below 1.0 predictedNHSN
SIR under 1.0
Fewer infections than predicted

Rate vs SIR

Rate

  • Per 1,000 device-days
  • Not risk-adjusted
  • Good for trending

SIR

  • Observed / predicted
  • Risk-adjusted
  • Needs 1.0 predicted

Local trend vs benchmark

Test Accuracy Metrics

Sensitivity
TP / (TP + FN)
Specificity
TN / (TN + FP)
PPV
TP / (TP + FP)
NPV
TN / (TN + FN)
Sensitivity finds cases
Few missed infections
PPV depends on prevalence
Falls in low-prevalence populationsTrap
Mean, median, mode
Measures of central tendency
Standard deviation
Spread around the mean

Sensitivity vs PPV

Sensitivity

  • TP / (TP + FN)
  • Property of the test
  • Prevalence independent

PPV

  • TP / (TP + FP)
  • Depends on prevalence
  • Answers: is it real

Test property vs result meaning

NHSN HAI Definitions

CLABSI line rule
In place >2 consecutive days
CLABSI eligibility starts
Central line day 3
Central line
Ends at/near the heart
CAUTI catheter rule
IUC >2 consecutive days
CAUTI removal rule
In place or removed yesterday
CAUTI culture threshold
100,000 CFU/ml, max 2 species
SSI default window
30 days post-procedure
SSI 90-day list
Implant-heavy procedure categories
Superficial incisional SSI
Always 30 days
VAC baseline
>=2 days stable oxygenation
VAC worsening
PEEP +3 or FiO2 +20
Secondary BSI
Not counted as CLABSI

SSI 90-Day Categories

BRST
Breast surgery
CARD / CBGB / CBGC
Cardiac and bypass procedures
CRAN
Craniotomy
FUSN
Spinal fusion
FX
Open fracture reduction
HER
Herniorrhaphy
HPRO / KPRO
Hip and knee prosthesis
PACE
Pacemaker surgery
PVBY
Peripheral vascular bypass
VSHN
Ventricular shunt

Outbreak Investigation Steps

Verify the diagnosis
Confirm laboratory results first
Confirm the outbreak
Compare against baseline rate
Notify stakeholders
Leadership, providers, public health
Write case definition
Clinical criteria plus time/place/person
Conduct case finding
Apply definition uniformly
Describe by epidemiology
Time, place, and person
Form hypothesis
Source and transmission mode
Implement control measures
Do not waitPriority
Test hypothesis
Case-control or cohort study
Evaluate and report
Confirm rates returned to baseline

Epidemic Curve Patterns

Point source
One sharp peak
Continuous common source
Plateau while exposure persists
Intermittent common source
Irregular repeated peaks
Propagated
Successive person-to-person peaks
Peak spacing
Roughly one incubation period
X axis
Onset date or time
Y axis
Number of cases

Surveillance Design Terms

Targeted surveillance
Selected units or procedures
Housewide surveillance
Whole facility, resource heavy
Process measure
Was the practice done
Outcome measure
Did infection occur
Numerator
Cases meeting the definition
Denominator
Population or device-days
Risk assessment
Drives the annual plan
Validation
Re-review records for accuracy
Benchmark rule
Same definitions and risk adjustment

WHO 5 Moments

Before patient | Before aseptic | After fluids | After patient | After surroundings

1 and 2 protect patient3, 4, 5 protect workerApplies to gloves too

Standard vs Transmission-Based

Standard

  • All patients always
  • Diagnosis irrelevant
  • PPE by task

Transmission-Based

  • Known or suspected pathogen
  • Added on top
  • Contact, droplet, airborne

Universal vs pathogen-specific

Precaution Picker

  1. Every patient, alwaysStandard Precautions(Baseline)
  2. Pulmonary tuberculosisAirborne(AIIR plus N95)
  3. Measles or varicellaAirborne(Immune staff preferred)
  4. Suspected disseminated zosterAirborne plus contact
  5. Influenza or pertussisDroplet(Surgical mask)
  6. Neisseria meningitidisDroplet(Until 24 hours therapy)
  7. MRSA, VRE, CREContact(Gown and gloves)
  8. C. difficileContact(Soap, sporicidal cleaning)
  9. Candida aurisContact(EPA List P)
  10. RSV or rotavirusContact(Pediatric units)
  11. Severely immunocompromised transplantProtective environment(Positive pressure)

Standard Precautions

Applies to
Every patient, every timeRule
Hand hygiene
Core component
PPE by task
Anticipated exposure decides
Respiratory hygiene
Cough etiquette, source masking
Safe injection practices
One needle, one syringe
Safe equipment handling
Clean between patients
Sharps safety
No recapping, use containers
Environmental cleaning
High-touch surfaces prioritized
Lumbar puncture mask
Worn for spinal procedures

Contact vs Droplet

Contact

  • Gown and gloves
  • Touch transmission
  • MRSA, VRE, C. difficile

Droplet

  • Surgical mask
  • Large respiratory particles
  • 3-foot separation

Touch vs respiratory spray

Hand Hygiene Picker

  1. Hands visibly soiledSoap and water
  2. C. difficile careSoap and water(Spores survive alcohol)
  3. Norovirus careSoap and water
  4. After restroom useSoap and water
  5. Hands not soiledAlcohol-based hand rub(Preferred default)
  6. Before aseptic procedureAlcohol-based hand rub
  7. Before surgerySurgical hand antisepsis

Transmission-Based Precautions

Layered on
Always added to Standard
Contact PPE
Gown and gloves
Contact examples
MRSA, VRE, C. difficile
Droplet PPE
Surgical mask on entry
Droplet separation
At least 3 feet
Droplet examples
Influenza, pertussis, meningococcus
Airborne PPE
N95 or higher respirator
Airborne examples
TB, measles, varicella
Patient transport
Mask the patient, notify receiver
Cohorting
Same organism, shared room

Alcohol Rub vs Soap

Alcohol rub

  • Faster and preferred
  • Kinder to skin
  • No sporicidal activity

Soap and water

  • Visibly soiled hands
  • C. difficile, norovirus
  • Physically removes spores

Kill vs physical removal

Hand Hygiene Rules

Alcohol rub is default
Faster, better skin tolerance
Alcohol concentration
At least 60% alcohol
Soap and water when
Hands visibly soiled
Also soap and water
C. difficile and norovirus
Also after restroom
And before eating
Wash duration
At least 15 seconds
Alcohol fails against
Bacterial spores
Best compliance measure
Direct observation
Artificial nails
Prohibited in high-risk care

Safe Injection Practices

One needle, one syringe
One patient, one time
Syringe reuse
Never, even with new needle
Single-dose vial
One patient only
Multi-dose vial
Disinfect septum every entry
Preparation area
Clean, away from contamination
Bags and tubing
One patient, then discard
Point-of-care devices
Dedicate or disinfect glucometers

Antimicrobial Stewardship

Leadership commitment
Dedicated funding and staffing
Accountability
Named program leader
Pharmacy expertise
Pharmacist co-leader
Action
Prospective audit and feedback
Tracking
Use and resistance data
Reporting
Share with prescribers
Education
Teach clinicians and patients
Preauthorization
Approval before restricted agent
Antibiotic time-out
Reassess at 48-72 hours
IV to oral
Convert when tolerating enterally

Emergency Preparedness

Mitigation
Reduce risk before events
Preparedness
Plan, train, stockpile
Response
Execute during the event
Recovery
Restore normal operations
Syndromic surveillance
Symptom patterns before diagnosis
Surge PPE planning
Burn rate and reserves
Category A agents
Anthrax, plague, smallpox, tularemia

Bloodborne Exposure Facts

Hepatitis B risk
22-31% if HBeAg-positive
Hepatitis C risk
About 0.2% percutaneous
HIV risk
About 0.3% percutaneous
Only vaccine-preventable
Hepatitis BTrap
First action
Wash site, report immediately
HIV PEP timing
Start within hours
HIV PEP duration
28 days
HBV post-exposure
HBIG plus vaccine, status-driven
HCV post-exposure
No PEP, test and treat

OSHA Requirements

Bloodborne standard
29 CFR 1910.1030
Exposure control plan
Written, reviewed annually
Hepatitis B vaccine
Free, within 10 working days
PPE cost
Employer pays, always
Sharps injury log
Required record of injuries
Engineering controls
Safety devices, sharps containers
Respiratory standard
29 CFR 1910.134
Fit test frequency
Before use, then annually
Seal check
Every single donning
Facial hair
Invalidates a tight seal

Personnel Health Screening

Core HCP vaccines
HepB, MMR, varicella, Tdap, influenza
HBV response check
Anti-HBs 1-2 months after
Non-responder
Repeat series, then evaluate
TB baseline
Screening on hire
Work restriction driver
Transmission risk to patients
Exposed susceptible staff
May need furlough
Product sensitivity
Offer latex-free alternatives

Blueprint Weights

Surveillance 20 is the biggest slice

Identify + transmission = 16.5 eachEnvironment + devices = 11.8 eachEducation 7.1 smallest

Quality Improvement Tools

PDSA
Plan, Do, Study, Act
Fishbone diagram
Groups possible causes
Pareto chart
Ranks the vital few
Flow chart
Maps the actual process
SWOT
Strengths, weaknesses, opportunities, threats
Gap analysis
Current versus required practice
Root cause analysis
Retrospective, after sentinel event
Run chart
Data plotted over time

Program Governance

Annual risk assessment
Foundation of the plan
Risk ranking
Probability times potential impact
IP plan contents
Goals, surveillance priorities, resources
Chain of command
Read the organizational chart
Media inquiries
Route to communications leadership
Notifiable disease authority
State or local, not CDC
Urgent reporting
Some conditions within 24 hours
Business case
Cost of infections avoided
Accreditation
Joint Commission, CMS conditions

Blueprint Item Counts

Identify diseases
14 items (16.5%)
Surveillance + investigation
17 items (20%)
Preventing transmission
14 items (16.5%)
Occupational health
7 items (8.2%)
Management + communication
7 items (8.2%)
Education + research
6 items (7.1%)
Environment of care
10 items (11.8%)
Device reprocessing
10 items (11.8%)
Scored total
85 itemsSum
CBIC publishes
Item counts, not percentages

PDSA Cycle

Plan | Do | Study | Act

Small rapid testsPredict before you doAdopt, adapt, abandon

Adult Learning + Evaluation

Adults learn best
Job-relevant and immediately applicable
Build on experience
Respect existing knowledge
Return demonstration
Best proof of skill
Teach-back
For patients and families
Attendance is not learning
Measure behavior insteadTrap
Process measure
Observed compliance rates
Outcome measure
Infection rates over time
Immediate feedback
Correct lapses privately, now

Evidence Hierarchy

Systematic review
Highest, synthesizes trials
Randomized controlled trial
Strongest single study
Cohort study
Follows exposed and unexposed
Case-control study
Starts from outcome backwards
Case series/report
Descriptive, no comparison group
Expert opinion
Lowest level of evidence
Check publication date
Guidelines are superseded
Peer review
Preferred over vendor literature

AIIR vs Protective Environment

AIIR

  • Negative pressure
  • Protects others
  • TB, measles, varicella

Protective environment

  • Positive pressure
  • Protects the patient
  • HEPA supply air

Contain vs shield

Disinfectant Picker

  1. C. difficile roomEPA List K(Sporicidal)
  2. Candida auris roomEPA List P
  3. Norovirus outbreakEPA List G
  4. Routine MRSA roomHospital-grade disinfectant
  5. Blood spill presentClean, then tuberculocidal product
  6. Surface still soiledClean before disinfecting

Environmental Cleaning

Clean before disinfect
Soil inactivates disinfectantsRule
Wet contact time
Follow the product label
Surface dries early
Reapply the disinfectant
Clean to dirty
Directional workflow
High to low
Work downward in room
High-touch surfaces
Rails, buttons, doorknobs, tables
Terminal cleaning
After discharge or transfer
Cleaning verification
ATP, fluorescent marker, culture

Cleaning vs Disinfection

Cleaning

  • Physically removes soil
  • Always comes first
  • Mechanical action

Disinfection

  • Kills remaining organisms
  • Needs wet contact time
  • Inactivated by soil

Remove then kill

EPA Product Lists

List K
Sporicidal, C. difficile
List P
Candida auris
List G
Norovirus
List N
SARS-CoV-2
Quats
Low-level, not sporicidal
Sodium hypochlorite
Common sporicidal choice
Sporicidal contact times
Usually longer than routine

Air and Water Systems

AIIR pressure
Negative, at least 2.5 Pa
AIIR in inches
0.01 inch water gauge
AIIR air changes
12 new, 6 existing
AIIR exhaust
Outdoors or HEPA-filtered
AIIR door
Kept closed, monitored daily
Protective environment
Positive pressure, HEPA supply
PE air changes
At least 12 hourly
PE patients
Allogeneic stem cell transplant
Legionella program
ASHRAE 188, CMS required
Legionella growth drivers
Stagnation, biofilm, scale, temperature
Legionella growth range
77-113°F (25-45°C)
Hot water storage
At least 140°F (60°C)

ICRA and Construction

ICRA inputs
Activity type plus patient risk
Done when
Before work beginsTiming
Primary hazard
Aspergillus in construction dust
Highest-risk patients
Neutropenic and transplant recipients
Rigid barriers
Required for Class III/IV
Work zone pressure
Negative to patient areas
HEPA exhaust
Filters construction air
Tacky mats
Capture dust at exit
Daily monitoring
Verify barriers and pressure

Waste and Linen

Regulated medical waste
Would release blood if compressed
Also regulated
Caked dried blood
Always regulated
Sharps, pathological, microbiological waste
Most room trash
Not regulated wasteTrap
Soiled linen handling
Minimal agitation, bag at use
Clean linen
Covered transport and storage
Sharps containers
Puncture-resistant, closable, upright

Spaulding Ladder

Sterile tissue | Mucous membrane | Intact skin

Critical = sterilizeSemicritical = high-levelNoncritical = low-levelUse decides, not name

HLD vs Sterilization

High-level disinfection

  • Kills all but spores
  • Semicritical items
  • Liquid chemical, timed

Sterilization

  • Kills spores too
  • Critical items
  • Steam, EtO, plasma

Mucous membranes vs sterile tissue

Reprocessing Picker

  1. Enters sterile tissueSterilization(Critical item)
  2. Enters vascular systemSterilization(Critical item)
  3. Touches mucous membranesHigh-level disinfection(Semicritical)
  4. Touches non-intact skinHigh-level disinfection(Semicritical)
  5. Touches intact skin onlyLow-level disinfection(Noncritical)
  6. Heat-sensitive critical deviceLow-temperature sterilization(EtO or plasma)
  7. Instrument still soiledClean again first(Never skip)
  8. Manufacturer conflicts with policyFollow the IFU

Spaulding Classification

Critical
Enters sterile tissue/vascular system
Critical requires
Sterilization
Semicritical
Contacts mucous membranes
Semicritical requires
High-level disinfection minimum
Noncritical
Touches intact skin only
Noncritical requires
Low-level disinfection
Category driver
Intended use, not nameRule
Examples critical
Implants, surgical instruments, catheters
Examples semicritical
Endoscopes, laryngoscope blades

Monitoring Triad

Physical | Chemical | Biological

Physical = gaugesChemical = exposureBiological = kill proof

Chemical vs Biological Indicator

Chemical indicator

  • Proves exposure only
  • Every package
  • Read immediately

Biological indicator

  • Proves spore kill
  • Weekly plus implants
  • Requires incubation

Exposed vs actually killed

Disinfection Levels

Sterilization
Destroys all microbes, spores included
High-level
All except many spores
Intermediate-level
Kills mycobacteria, tuberculocidal claim
Low-level
Vegetative bacteria, enveloped viruses
OPA 0.55%
12 minutes at 20°C
Glutaraldehyde 2%
20 minutes at 20°C
Other HLD agents
Follow FDA-cleared label
Alcohol limitation
Not sporicidal, evaporates fast

Sterilization Parameters

Gravity displacement
121°C for 30 minutes
Prevacuum wrapped
132°C for 4 minutes
IUSS unwrapped
132°C for 3 minutes
Four steam requirements
Time, temperature, steam, contact
Air is the enemy
Blocks steam penetration
Ethylene oxide
Heat-sensitive devices, long aeration
Hydrogen peroxide plasma
Low temperature, no cellulose
Dry heat
Oils, powders, anhydrous materials
IUSS restriction
Not routine; avoid implants

Sterilizer Monitoring

Physical monitors
Gauges, printouts, cycle charts
Chemical indicator
Shows exposure, not sterilityTrap
Internal CI
Inside every package
External CI
When internal is hidden
Biological indicator
Only true kill proof
Steam and plasma BI
Geobacillus stearothermophilus
EtO and dry heat
Bacillus atrophaeus
BI frequency
At least weekly, daily preferred
Implant loads
Every load, hold until negative
Bowie-Dick test
Daily, empty prevacuum chamber
Bowie-Dick timing
Before first processed load
Positive BI
Quarantine sterilizer, recall loads

Reprocessing Workflow

Point-of-use treatment
Keep soil moist
Transport
Closed, leak-proof container
Clean
The step everything depends on
Rinse and dry
Before disinfection or packaging
Inspect
Check function and residual soil
Package and sterilize
Or high-level disinfect
Storage
Controlled, dry, event-related sterility
Workflow direction
Dirty to clean to sterile
Biofilm
Defeats sterilization if left
IFU
Manufacturer instructions govern

Common Traps

Colonization vs infection

Colonization is not counted Infection meets surveillance criteria

Incidence vs prevalence

Incidence counts new cases Prevalence counts all cases

Alcohol rub vs spores

Alcohol kills vegetative bacteria Soap removes C. difficile spores

Chemical vs biological indicator

Chemical proves exposure only Biological proves spores died

Cleaning vs disinfection

Cleaning removes the soil Disinfection kills what remains

Device name vs use

Spaulding follows intended use Not the device label

Rate vs SIR

Rates are not risk-adjusted SIR compares to prediction

AIIR vs protective environment

AIIR is negative pressure PE is positive pressure

Total vs scored items

Exam has 100 items Only 85 are scored

Attendance vs learning

Sign-in sheets prove attendance Observation proves behavior change

Regulated vs routine waste

Most room trash is routine Saturated, sharps, pathological only

Reporting authority

States set notifiable lists CDC does not mandate

Last Minute

  1. 1.100 items, only 85 scored
  2. 2.Pass = 700 scaled; range 300-900
  3. 3.Passing candidates get no number
  4. 4.Forward-only: no skipping, no going back
  5. 5.Surveillance 20% is the heaviest area
  6. 6.Chain of infection has six links
  7. 7.Standard Precautions = every patient always
  8. 8.Airborne = N95 + negative-pressure room
  9. 9.Droplet = surgical mask, 3 feet
  10. 10.Contact = gown + gloves on entry
  11. 11.C. difficile = soap + EPA List K
  12. 12.Candida auris = EPA List P
  13. 13.Device rate = infections / device-days x 1,000
  14. 14.Attack rate = ill / at-risk x 100
  15. 15.SIR = observed / predicted infections
  16. 16.No SIR when predicted below 1.0
  17. 17.CLABSI and CAUTI: line >2 days
  18. 18.SSI = 30 days; some 90
  19. 19.Critical = sterilize; semicritical = high-level
  20. 20.Gravity = 121°C for 30 min
  21. 21.Prevacuum = 132°C for 4 min
  22. 22.Biological indicator = only kill proof
  23. 23.Bowie-Dick daily in empty chamber
  24. 24.Clean first; disinfectants need wet time
  25. 25.HepB vaccine within 10 working days
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