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Which immunoglobulin class binds with highest affinity to the FcεRI receptor on mast cells and basophils and is central to Type I hypersensitivity?

A
B
C
D
to track
2026 Statistics

Key Facts: ABAI Exam

225

Multiple-Choice Items

ABAI 2026 exam format

7 hrs

Exam Duration (2 sessions)

ABAI

$2,650

Certification Exam Fee

ABAI 2026 Schedule of Fees

$239,200

Median Annual Wage

BLS SOC 29-1229 May 2024

~5,000

US Board-Certified Allergists

AAAAI workforce estimates

7 yrs

Board Eligibility Window

From fellowship completion

The ABAI Certification Examination certifies roughly 5,000 US board-certified allergists/immunologists. The 2026 fee is $2,650 for a 225-item, 7-hour Pearson VUE exam covering hypersensitivity (54%), immunological disorders (45%), and pharmacology. Candidates must complete an ACGME-accredited A/I fellowship and achieve certification within 7 years. BLS reports median pay of $239,200 for Physicians All Other (SOC 29-1229) and $236,000 for General Internal Medicine (SOC 29-1216) in May 2024, with allergy/immunology subspecialists commonly earning at the higher end of that range.

Sample ABAI Practice Questions

Try these sample questions to test your ABAI exam readiness. Each question includes a detailed explanation. Start the interactive quiz above for the full 100+ question experience with AI tutoring.

1Which immunoglobulin class binds with highest affinity to the FcεRI receptor on mast cells and basophils and is central to Type I hypersensitivity?
A.IgG4
B.IgA
C.IgE
D.IgM
Explanation: IgE binds FcεRI on mast cells and basophils with nanomolar affinity (Kd ~10^-10 M), sensitizing these cells for immediate hypersensitivity. Cross-linking of receptor-bound IgE by allergen triggers degranulation and release of histamine, tryptase, and lipid mediators.
2A 32-year-old woman is stung by a yellow jacket and develops hypotension and airway edema. Which is the first-line intramuscular epinephrine dose for an adult weighing 60 kg?
A.0.15 mg IM
B.0.30 mg IM
C.0.50 mg IV push
D.1.0 mg IM
Explanation: The standard adult IM epinephrine dose for anaphylaxis is 0.3 mg (0.01 mg/kg, max 0.5 mg) into the anterolateral thigh. This corresponds to a 0.3 mg EpiPen autoinjector. IV epinephrine is reserved for refractory shock and must be given as a titrated infusion.
3In Gell and Coombs classification, which hypersensitivity type is mediated by immune complexes deposited in tissues with subsequent complement activation?
A.Type I
B.Type II
C.Type III
D.Type IV
Explanation: Type III hypersensitivity is immune-complex mediated. Antigen-antibody complexes (usually IgG or IgM) deposit in small vessels, basement membranes, or synovium, activating complement and recruiting neutrophils. Examples include serum sickness, post-streptococcal glomerulonephritis, and SLE.
4Which diagnostic test is considered the gold standard for confirming or refuting IgE-mediated food allergy?
A.Skin prick testing
B.Serum specific IgE (ImmunoCAP)
C.Double-blind placebo-controlled oral food challenge
D.Component-resolved diagnostics
Explanation: Double-blind placebo-controlled oral food challenge (DBPCFC) remains the gold standard for diagnosing food allergy. Skin tests and specific IgE have high sensitivity but relatively low specificity (many sensitized individuals tolerate the food). Open or single-blind challenges are commonly used in practice.
5A newborn screening program identifies low T-cell receptor excision circles (TRECs). Which condition is this screen designed to detect?
A.Chronic granulomatous disease
B.Severe combined immunodeficiency (SCID)
C.Common variable immunodeficiency
D.Complement C1 inhibitor deficiency
Explanation: The TREC assay detects low numbers of recently produced naive T cells and is specifically used to screen newborns for SCID and other severe T-cell lymphopenias. Early detection enables hematopoietic stem cell transplantation before life-threatening infections develop.
6Which cytokine is the primary target of dupilumab?
A.IL-5
B.IL-4Rα (blocking IL-4 and IL-13)
C.IgE
D.TSLP
Explanation: Dupilumab binds IL-4 receptor alpha (IL-4Rα), blocking signaling of both IL-4 and IL-13 — the central cytokines driving type 2 inflammation. It is FDA-approved for atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, and prurigo nodularis.
7A 6-year-old boy has recurrent sinopulmonary infections since infancy, absent tonsils, and undetectable serum IgG, IgA, and IgM with absent CD19+ B cells. Which genetic defect is most likely?
A.BTK mutation
B.CD40L mutation
C.WASP mutation
D.AIRE mutation
Explanation: X-linked agammaglobulinemia (XLA, Bruton) is caused by mutations in BTK (Bruton tyrosine kinase), blocking B-cell maturation at the pre-B stage. Affected boys have absent or very low circulating CD19+ B cells and undetectable immunoglobulins. Treatment is lifelong immunoglobulin replacement.
8A 28-year-old with moderate persistent asthma is on low-dose ICS-formoterol. Under GINA 2024 Track 1, how should she use her ICS-formoterol inhaler?
A.Only as a daily controller
B.As daily controller plus SABA rescue
C.As both maintenance and reliever (MART/SMART)
D.Only as a rescue inhaler during exacerbations
Explanation: GINA Track 1 recommends ICS-formoterol as both maintenance and reliever therapy (MART/SMART) across Steps 1-5. This approach reduces severe exacerbations compared with SABA-only reliever strategies because each reliever dose also delivers anti-inflammatory ICS.
9Which of the following is the first-line disease-modifying therapy for peanut allergy in children aged 4-17?
A.Omalizumab monotherapy
B.Palforzia (AR101) peanut oral immunotherapy
C.Sublingual peanut immunotherapy
D.Epicutaneous peanut immunotherapy (Viaskin)
Explanation: Palforzia (AR101) is FDA-approved defatted peanut flour oral immunotherapy for peanut-allergic patients aged 4-17. It gradually desensitizes patients to tolerate ~300-600 mg peanut protein (protection against accidental ingestion). In 2024, omalizumab (Xolair) was also approved as monotherapy for IgE-mediated food allergies.
10A 40-year-old man has recurrent episodes of non-pitting, non-pruritic angioedema of the face, lips, and abdomen unresponsive to antihistamines. His C4 level is low. What is the most likely diagnosis?
A.Chronic spontaneous urticaria
B.Hereditary angioedema
C.ACE inhibitor-induced angioedema
D.Systemic mastocytosis
Explanation: Recurrent angioedema without urticaria, lack of response to antihistamines, and low C4 are classic for hereditary angioedema (HAE). C4 is chronically consumed due to unopposed C1 activation. C1-INH quantitative (Type I) or functional (Type II) testing confirms the diagnosis.

About the ABAI Exam

The ABAI Certification Examination is the subspecialty board exam for physicians who have completed an ACGME-accredited fellowship in allergy and immunology. The exam is delivered once per year at Pearson VUE centers and contains 225 one-best-answer multiple-choice items split 25% basic science and 75% clinical science. Blueprint domains cover hypersensitivity and allergic disease (54%), immunological disorders (45%), and pharmacology/allergens (small remaining share). Passing requires achieving the criterion-referenced standard set in advance by the Conjoint Standards Committee representing ABAI, ABIM, and ABP.

Questions

225 scored questions

Time Limit

7 hours (two sessions, one test day)

Passing Score

Criterion-referenced absolute minimum

Exam Fee

$2,650 (ABAI)

ABAI Exam Content Outline

11%

Head & Neck (Rhinitis, Sinusitis)

Allergic and non-allergic rhinitis, CRSwNP, allergic fungal sinusitis, ocular allergy, cough workup

11%

Dermatologic (AD, Urticaria, Angioedema)

Atopic dermatitis, contact hypersensitivity, chronic urticaria, hereditary and acquired angioedema

11%

Lung (Asthma, ABPA, HP)

Asthma GINA/NAEPP, occupational asthma, ABPA, hypersensitivity pneumonitis, EGPA, pulmonary diagnostics

11%

Food & Drug Allergy

Oral food challenge, OIT (Palforzia), penicillin testing, beta-lactam cross-reactivity, NSAID hypersensitivity

10%

Anaphylaxis & Mast Cell Disorders

Idiopathic, exercise-induced, latex, venom anaphylaxis, mastocytosis, alpha-gal syndrome

16%

Immunodeficiencies

SCID (TREC), CVID, XLA, HIES (Job syndrome), 22q11.2 DiGeorge, complement and phagocyte defects

10%

Immune Inflammatory & Autoimmune

SLE/RA overlap, autoinflammatory periodic fevers, vaccination and immunomodulator management

6%

Eosinophilic & GI Disorders

Eosinophilic esophagitis, hypereosinophilic syndromes, IBD, celiac disease

9%

Basic Immunology & Research

Gell-Coombs hypersensitivity, cytokines, complement, biostatistics and research methods

5%

Pharmacology & Immunotherapy

SCIT/SLIT, biologics (omalizumab, mepolizumab, benralizumab, dupilumab, tezepelumab), HAE therapies

How to Pass the ABAI Exam

What You Need to Know

  • Passing score: Criterion-referenced absolute minimum
  • Exam length: 225 questions
  • Time limit: 7 hours (two sessions, one test day)
  • Exam fee: $2,650

Keys to Passing

  • Complete 500+ practice questions
  • Score 80%+ consistently before scheduling
  • Focus on highest-weighted sections
  • Use our AI tutor for tough concepts

ABAI Study Tips from Top Performers

1Master immunodeficiencies first — at 16%, this is the single largest blueprint domain and a common discriminator between pass and fail
2Memorize biologic indications cold: omalizumab (allergic asthma/CSU/CRSwNP/food), mepolizumab and benralizumab (eosinophilic asthma), dupilumab (type 2 asthma/AD/EoE/CRSwNP), tezepelumab (TSLP, severe asthma regardless of phenotype)
3Know the Gell-Coombs framework and how Types I-IV map to specific diseases, timings, and mediators — basic science questions lean on this
4Drill HAE pathophysiology and therapeutics: C1-INH concentrate, lanadelumab (prophylaxis), icatibant (B2 receptor antagonist), berotralstat (oral kallikrein inhibitor), ecallantide
5Use practice mocks under exam-day pacing (225 items / ~7 hours) to build stamina for the two-session format

Frequently Asked Questions

How many questions are on the ABAI Certification Examination?

The ABAI Certification Exam contains 225 one-best-answer multiple-choice items delivered across two sessions in approximately 7 hours at Pearson VUE test centers. Content is split 25% basic science and 75% clinical science, with blueprint weights covering hypersensitivity disorders (54%), immunological disorders (45%), and a small pharmacology/allergens component.

What is the ABAI exam passing score?

ABAI uses a criterion-referenced absolute minimum passing score set before each administration by the Conjoint Standards Committee (ABAI, ABIM, ABP representatives). There is no percentile curve — theoretically all candidates can pass or all can fail. The standard is based on the probability of an average competent allergist/immunologist answering each item correctly.

Who is eligible to take the ABAI Certification Exam?

Candidates must have completed an ACGME-accredited fellowship in Allergy and Immunology and hold prior ABIM (internal medicine) or ABP (pediatrics) certification. Certification must be achieved within 7 years of fellowship completion; candidates who miss that window must complete an additional year of ACGME-approved A/I retraining. Dual pathways exist with pediatric pulmonology, adult rheumatology, and pediatric rheumatology.

How much does the ABAI Certification Exam cost in 2026?

The 2026 ABAI Certification Examination fee is $2,650. A $500 non-refundable late application fee applies after the deadline. If a candidate cancels before the deadline, $1,850 is refundable ($800 is retained as a non-refundable evaluation and processing fee). Rescore requests cost $100 and must be submitted within 30 days of the results letter via certified mail.

How often is the ABAI exam offered?

The ABAI Certification Examination is offered once per year. Dates and Pearson VUE locations are announced through ABAI newsletters, the ABAI website, and specialty journals. Because Pearson VUE administers many exams, ABAI cannot guarantee preferred date or site availability — register early.

How should I study for the ABAI boards?

Most successful candidates combine the AAAAI Review Course, Middleton's Allergy: Principles and Practice, Stiehm's Immunologic Disorders in Infants and Children, and a dedicated question bank. Focus heavily on immunodeficiencies (16% — the largest single section), GINA/NAEPP asthma updates, biologics indications, HAE management, and the Gell-Coombs framework. Use the In-Training Examination results to guide weak-area review.

What happens if I fail the ABAI exam?

There is no limit on the number of retake attempts, but the 7-year board eligibility window still applies. If the 7-year window closes without certification, candidates must complete one additional ACGME-approved fellowship year. Diplomates who already had multiple attempts before the 2019 policy change received a 2-year extension to complete certification.

What is the job outlook for allergy/immunology physicians?

The BLS reports median annual wages of $239,200 for Physicians, All Other (SOC 29-1229) and $236,000 for Internal Medicine Physicians (SOC 29-1216) as of May 2024, with total physician employment projected to grow 4% from 2023-2033. Approximately 5,000 US physicians hold active ABAI certification; the AAAAI estimates roughly 140-150 new A/I fellowship graduates enter the workforce each year, making allergy/immunology one of the smallest internal medicine subspecialties by workforce size.