A patient is being evaluated for an allogeneic hematopoietic stem cell transplant. Which factor is MOST critical in donor selection?
Tctcn Pre Transplant Evaluation
Question · Medium
Which conditioning regimen classification is associated with reduced transplant-related mortality but higher relapse rates?
Protein marker found on most cells that a transplant team types to find a close donor match.
Transplant foundations
Guess the Term
Introduction & Exam Overview
1.1 The TCTCN Credential: Rename, Scope & Official Test Blueprint
Study guide
During informed consent for hematopoietic stem cell transplant, which information is essential to communicate to the patient?
Question · Easy
Read the clue and guess the term in 6 tries.
Game
A patient scheduled for autologous stem cell transplant requires peripheral blood stem cell (PBSC) mobilization. Which agent is most commonly used to mobilize stem cells?
Person outside the patient's family, found on the NMDP Registry, whose HLA type is a complete 8/8 fit for the patient.
What is the minimum target CD34+ cell dose typically required for adequate engraftment in autologous peripheral blood stem cell transplant?
Question · Hard
A patient undergoing pre-transplant evaluation has an ejection fraction of 38%. What does this finding indicate?
Cell therapy made by expanding immune cells already present inside a solid cancer; lifileucel was the first FDA-approved product of this type.
1.2 TCTCN Eligibility, Test-Day Logistics, Scoring & Renewal
Which disease has the BEST overall survival outcomes following allogeneic hematopoietic stem cell transplant when performed in first complete remission?
Swap tiles to line up three of the same term.
Term Match
Which myeloablative conditioning regimen is MOST commonly used for patients with acute myeloid leukemia undergoing allogeneic transplant?
Established therapy for relapse after transplant that works through the graft-versus-leukemia effect.
What is the primary purpose of pre-transplant HCT-CI (Hematopoietic Cell Transplant Comorbidity Index) assessment?
A patient asks the nurse why a central venous catheter (CVC) is needed before transplant. Which response is MOST appropriate?
Preparative treatment that is both cytotoxic and immunosuppressive and reaches all tissues uniformly.
Process and administration
1.3 Building the Study Plan & Clinical Prioritization Framework
What is the primary purpose of cryopreservation in autologous stem cell transplant?
Tctcn Transplant Phase
Flip two cards at a time to find matching terms.
Term Pairs
During stem cell infusion, the patient develops facial flushing, nausea, and a garlic-like taste. What is the MOST likely cause?
The standard chemical added to a frozen stem cell product to stop ice crystals from damaging the cells.
What is the typical timeframe for neutrophil engraftment following peripheral blood stem cell transplant?
A patient is at day +3 post-allogeneic transplant with an ANC of 0. Which nursing intervention has the HIGHEST priority?
Graft collected by apheresis after five days of filgrastim, rather than by marrow harvest.
1.4 Clinical Triage Rehearsal & Exam-Day Question Strategy
Which complication is most concerning when infusing ABO-incompatible stem cells during a major ABO-mismatched allogeneic transplant?
Find five hidden terms in a grid of letters.
Term Search
Mucositis following myeloablative conditioning typically peaks at which time point post-transplant?
Preparative regimen between myeloablative and nonmyeloablative, with alkylator or TBI doses cut by at least 30%, that still needs stem cell support.
Which medication is used as GVHD prophylaxis starting before or on the day of allogeneic stem cell infusion?
A transplant patient at day +5 develops a temperature of 38.5 degrees C (101.3 degrees F) with an ANC of 100. What is the FIRST nursing action?
Complication whose acute form usually appears in the early weeks after transplant and whose chronic form usually starts within a year but can appear years later.
Post-transplant care
Chapter 2: Foundations of Transplantation & Cellular Biology
2.1 Hematopoietic Lineage, the MHC & HLA Class I vs Class II Biology
Which electrolyte abnormality is MOST commonly associated with high-dose cyclophosphamide conditioning?
Nursing & Healthcare Exam Prep Podcast
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Podcast
What is the primary purpose of irradiated blood products for transplant patients?
Current name for the liver complication formerly called veno-occlusive disease, marked by jaundice, painful enlarged liver, weight gain and abdominal fluid.
Hemorrhagic cystitis from cyclophosphamide conditioning is caused by which toxic metabolite?
Which assessment finding is the EARLIEST indicator of engraftment syndrome?
Blood level that confirms successful engraftment when it stays at or above 500 cells per microliter for three days.
2.2 HLA Typing Resolution, Donor Matching, DSA & ABO Compatibility
Which organ is MOST commonly affected by acute graft-versus-host disease (aGVHD)?
Tctcn Post Transplant Management
A patient at day +30 develops stage 3 skin GVHD with generalized erythroderma covering more than 50% body surface area. What is the overall grade of acute GVHD based on skin staging alone?
Herpesvirus that is the most common infectious cause of birth defects in the US and can reactivate after transplant when immunity is suppressed.
What is the first-line treatment for acute graft-versus-host disease?
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