A 45-year-old female presents with a 1-year history of widespread musculoskeletal pain, chronic fatigue, poor sleep, and cognitive difficulties ('brain fog'). Physical exam reveals multiple tender points but no joint swelling or muscle weakness. Extensive laboratory testing (including CBC, ESR, CRP, TSH, and ANA) is entirely normal. What is the most appropriate first-line pharmacological agent for this patient's condition?
- AAmitriptyline or Pregabalin
- BOral Prednisolone 10 mg daily
- COxycodone controlled-release
- DLong-term daily Celecoxib