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Read the passage: 'In pulmonary physiology, gas exchange across the alveolar-capillary membrane is governed primarily by passive diffusion according to Fick's law. Efficient diffusion requires an exceedingly thin tissue barrier and an expansive surface area, both of which are compromised in chronic fibrotic lung disorders.' What is the primary physiological consequence when alveolar tissue becomes fibrotic?

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Read the passage: 'Endocrine hormones travel systemically through the bloodstream, yet they elicit physiological responses only in specific target tissues. This selectivity is mediated by cell-surface or intracellular receptor proteins whose stereochemical configuration permits high-affinity binding exclusively to corresponding hormonal ligands.' What accounts for the tissue specificity of hormones?

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