Read the following passage:
'Epigenetic modifications, such as DNA methylation and histone acetylation, alter gene expression without changing the underlying nucleotide sequence. For decades, the central dogma of molecular biology was interpreted as a deterministic blueprint where phenotypic outcomes were strictly dictated by inherited alleles. However, epidemiological studies of populations exposed to severe famine—such as the Dutch Hunger Winter of 1944–1945—demonstrated that prenatal nutritional deprivation led to persistent metabolic alterations in offspring, including elevated rates of obesity and cardiovascular disease in adult life, mediated by differential methylation of the IGF2 gene.'
What is the primary function of the reference to the Dutch Hunger Winter in the passage?
- ATo refute the existence of inherited alleles and disprove Mendelian genetics entirely.
- BTo demonstrate that environmental insults during gestation can induce lasting phenotypic…
- CTo argue that prenatal famine increases life expectancy by reducing adult caloric require…
- DTo prove that DNA methylation causes permanent, irreversible mutations in nucleotide sequ…