HESI A2 Exam 2026: Sections, Scores & Study Plan
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Which layer of the skin contains blood vessels, nerves, hair follicles, and sweat glands?
Integumentary System
Question · Easy
The HESI A2 is modular with up to 10 sections and no universal pass mark. See scored vs. pilot question counts, 2026 score requirements by school, and a free study plan.
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What is the primary protein that gives the epidermis its waterproof, protective quality?
Chapter 1: Anatomical Terminology & Body Organization
1.1 Directional Terms, Anatomical Position & Body Planes
Study guide
Which cells in the epidermis produce pigment that absorbs ultraviolet radiation?
Question · Medium
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Sebaceous glands secrete which substance?
Which type of sweat gland is most numerous and produces a watery secretion for thermoregulation?
Which of the following is NOT a function of the skin?
1.2 Body Cavities, Abdominopelvic Regions & Quadrants
In which sublayer of the epidermis does active cell division (mitosis) primarily occur?
Question · Hard
A second-degree burn involves damage to which layer(s) of the skin?
How many bones are in the adult human skeleton?
Skeletal System
Which of the following is part of the axial skeleton?
1.3 Homeostasis & Feedback Mechanisms
Where are red blood cells produced in adults?
Which cells are responsible for breaking down bone matrix?
Which type of joint allows movement in only one plane, such as flexion and extension at the elbow?
How many vertebrae are in the cervical region of the spine?
Chapter 2: Cellular Biology & Histology
2.1 Cellular Organelles & Membrane Transport
Which structure connects bone to bone at a joint?
Which bone of the skull protects the pituitary gland in the sella turcica?
Which of the following is the longest and strongest bone in the human body?
What type of cartilage covers the articulating surfaces of bones in synovial joints?
2.2 Cell Cycle, Mitosis & Meiosis
Which of the following is a function of the skeletal system?
Which type of muscle tissue is striated, voluntary, and attached to bones?
Muscular System
What is the functional contractile unit of a skeletal muscle fiber?
Which neurotransmitter is released at the neuromuscular junction to stimulate skeletal muscle contraction?
2.3 Four Primary Tissue Types
Which ion is directly responsible for exposing the actin-binding sites and initiating cross-bridge cycling in muscle contraction?
The biceps brachii primarily performs which action at the elbow joint?
What is the role of myosin in skeletal muscle contraction?
Which muscle is the primary muscle of inspiration during quiet breathing?
Chapter 3: Integumentary System
3.1 Epidermis Layers, Cells & Pigmentation
A muscle that opposes the action of another muscle is called the:
Which compound provides the immediate energy for muscle contraction?
Which part of the brain is responsible for coordination, balance, and fine motor control?
Nervous System
Which structural component of a neuron receives signals from other neurons?
3.2 Dermis, Hypodermis & Cutaneous Glands
Which structures of the central nervous system are composed of cell bodies and unmyelinated fibers?
Which division of the autonomic nervous system is responsible for the 'fight-or-flight' response?
How many pairs of cranial nerves originate from the brain?
Which cranial nerve innervates the diaphragm to control breathing?
3.3 Skin Functions, Thermoregulation & Wound Repair
What is the function of the myelin sheath on an axon?
During an action potential, the depolarization phase is caused by the influx of which ion?
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