Key Takeaways

  • Standard precautions apply to ALL patients regardless of diagnosis: hand hygiene, gloves, gown, mask/eye protection as needed
  • Contact precautions: gown + gloves for MRSA, VRE, C. diff, scabies; dedicated equipment
  • Droplet precautions: surgical mask within 3-6 feet for influenza, pertussis, meningococcal meningitis, COVID-19 (minimum)
  • Airborne precautions: N95 respirator + negative pressure room for TB, measles, varicella, COVID-19 (ideal)
  • VAP prevention bundle: HOB elevation 30-45 degrees, daily sedation vacation, DVT prophylaxis, stress ulcer prophylaxis, daily oral care with chlorhexidine, daily assessment of extubation readiness
  • Hand hygiene is the single most effective measure to prevent healthcare-associated infections
  • Alcohol-based hand rub (ABHR) is preferred for hand hygiene EXCEPT when hands are visibly soiled or C. diff is suspected (use soap and water)
  • Ventilator circuit changes should NOT be done routinely; only change when visibly soiled or malfunctioning
Last updated: February 2026

Infection Control & Prevention

Infection control questions appear in the Troubleshooting & Infection Control domain (14% of the TMC exam). Respiratory therapists have extensive patient contact and handle equipment that is directly connected to patients' airways, making strict adherence to infection control practices essential.

Standard Precautions (Apply to ALL Patients)

Standard precautions are based on the principle that all blood, body fluids, secretions, excretions (except sweat), non-intact skin, and mucous membranes may be infectious. These apply to every patient encounter, regardless of known or suspected diagnosis.

MeasureWhen to Use
Hand hygieneBefore and after every patient contact; before clean/aseptic procedures; after body fluid exposure; after touching patient surroundings
GlovesContact with blood, body fluids, mucous membranes, non-intact skin; handling contaminated equipment
GownWhen clothing may contact blood/body fluids; during procedures with splash potential
Mask + Eye protectionProcedures likely to generate splashes or sprays (suctioning, intubation, bronchoscopy)
Respiratory hygieneCover cough/sneeze; hand hygiene after contact with respiratory secretions
Safe injection practicesSingle-use needles/syringes; single-dose vials preferred
Sharps disposalImmediately into puncture-resistant container; never recap needles

Transmission-Based Precautions

TypeProtectionRoomCommon Pathogens
ContactGown + gloves; dedicated equipmentStandard room; may cohort patientsMRSA, VRE, C. difficile, scabies, RSV, wound infections
DropletSurgical mask within 3-6 feet of patientStandard room; door may remain openInfluenza, pertussis, meningococcal disease, mumps, COVID-19 (minimum)
AirborneN95 respirator (fit-tested); negative pressure roomAirborne Infection Isolation Room (AIIR); 6-12 air changes/hour; negative pressureTuberculosis (TB), measles, varicella (chickenpox), COVID-19 (ideal)

Hand Hygiene — The #1 Infection Prevention Measure

Alcohol-Based Hand Rub (ABHR):

  • Preferred method for routine hand hygiene
  • Effective against most bacteria and viruses
  • Apply liberally, rub all surfaces for 20-30 seconds until dry
  • NOT effective against: C. difficile spores, Norovirus (use soap and water instead)

Soap and Water:

  • Required when hands are visibly soiled with blood or body fluids
  • Required when C. difficile is known or suspected (spores resist alcohol)
  • Wash for at least 20 seconds with friction
  • Required before eating and after using the restroom

VAP Prevention Bundle

Ventilator-Associated Pneumonia (VAP) is a serious complication of mechanical ventilation. The VAP prevention bundle includes evidence-based practices that reduce VAP incidence:

InterventionRationale
Head of bed (HOB) elevation 30-45 degreesReduces aspiration of gastric contents
Daily sedation vacation (SAT)Facilitates earlier extubation; reduces ventilator days
Daily assessment of extubation readinessReduces duration of mechanical ventilation
DVT prophylaxisPrevents venous thromboembolism (SCD boots, heparin)
Stress ulcer prophylaxisPrevents GI bleeding (PPI or H2 blocker)
Oral care with chlorhexidineReduces oropharyngeal bacterial colonization
Subglottic secretion drainageRemoves pooled secretions above the ET cuff
Closed suction systemsMaintains circuit integrity; reduces contamination

Equipment Sterilization and Disinfection

LevelProcessUsed For
SterilizationKills ALL microorganisms including spores (autoclave, ethylene oxide)Surgical instruments, items entering sterile body areas
High-level disinfectionKills all organisms except high numbers of spores (glutaraldehyde, OPA)Bronchoscopes, reusable breathing circuits
Intermediate disinfectionKills most bacteria, fungi, viruses, mycobacteria (alcohol, bleach)Stethoscopes, ventilator surfaces
Low-level disinfectionKills most bacteria, some viruses and fungi (quaternary ammonium compounds)Non-critical surfaces, countertops

Ventilator Circuit Management

  • Do NOT routinely change ventilator circuits — change only when visibly soiled or malfunctioning
  • Routine circuit changes increase (not decrease) the risk of VAP
  • HMEs: Change every 48 hours or when visibly soiled/clogged
  • Heated humidifier circuits: Drain condensation away from patient; avoid allowing condensate to reach the patient
Test Your Knowledge

A patient is admitted with suspected active pulmonary tuberculosis. Which type of precautions should be implemented?

A
B
C
D
Test Your Knowledge

When should alcohol-based hand rub (ABHR) NOT be used, requiring soap and water instead?

A
B
C
D
Test Your Knowledge

Which of the following is included in the VAP prevention bundle?

A
B
C
D
Test Your KnowledgeMatching

Match each pathogen to the appropriate transmission-based precaution level.

Match each item on the left with the correct item on the right

1
MRSA (wound infection)
2
Active pulmonary tuberculosis
3
Influenza
4
Measles (rubeola)
5
C. difficile
Test Your Knowledge

How often should ventilator circuits be routinely changed to prevent VAP?

A
B
C
D
Test Your Knowledge

A patient with MRSA pneumonia requires respiratory therapy treatment. Which precautions should the RT use?

A
B
C
D
Test Your Knowledge

Which level of disinfection is required for reprocessing a reusable bronchoscope?

A
B
C
D
Test Your KnowledgeMulti-Select

Which of the following are components of the VAP prevention bundle? (Select all that apply)

Select all that apply

Head of bed elevation 30-45 degrees
Daily sedation vacation
Routine ventilator circuit changes every 48 hours
Daily assessment of extubation readiness
Oral care with chlorhexidine