Key Takeaways

  • The upper airway includes the nose, mouth, pharynx (nasopharynx, oropharynx, laryngopharynx), and larynx
  • The lower airway begins at the trachea and includes the mainstem bronchi, lobar bronchi, segmental bronchi, bronchioles, and alveoli
  • The right mainstem bronchus is shorter, wider, and more vertical than the left, making it the most common site for aspiration and right mainstem intubation
  • The epiglottis covers the glottic opening during swallowing to prevent aspiration
  • The cricoid cartilage is the only complete cartilage ring in the airway and is the narrowest point in pediatric airways
  • Signs of respiratory distress include tachypnea, accessory muscle use, nasal flaring, retractions, diaphoresis, and inability to speak in full sentences
  • Signs of impending respiratory failure include altered mental status, paradoxical breathing, bradycardia, central cyanosis, and exhaustion
  • The Mallampati score (I-IV) predicts difficulty of intubation based on visualization of pharyngeal structures
Last updated: February 2026

Airway Anatomy & Assessment

A thorough understanding of airway anatomy is essential for every respiratory therapist. The airway is divided into upper and lower segments, each with distinct structures and clinical considerations. The TMC exam extensively tests your knowledge of airway anatomy, assessment of respiratory distress, and recognition of conditions requiring urgent intervention.

Upper Airway Anatomy

The upper airway extends from the nose and mouth to the larynx and serves to warm, filter, and humidify inspired air.

StructureKey FeaturesClinical Significance
Nasal cavityTurbinates warm and humidify air; mucous membranes trap particlesNasal intubation route; epistaxis risk
Oral cavityContains tongue (most common cause of upper airway obstruction)OPA placement; suctioning access
NasopharynxSuperior portion; adenoids located hereNPA placement route
OropharynxBehind the mouth; contains base of tongueMost common obstruction site in unconscious patients
LaryngopharynxDivides into trachea (anterior) and esophagus (posterior)Aspiration risk zone
EpiglottisLeaf-shaped cartilage; covers glottis during swallowingEpiglottitis = medical emergency
LarynxContains vocal cords; thyroid and cricoid cartilagesLandmark for cricothyrotomy; voice production
GlottisSpace between the vocal cordsNarrowest point in adult airway

Lower Airway Anatomy

The lower airway begins at the trachea and conducts air to the alveoli for gas exchange.

StructureKey FeaturesClinical Significance
Trachea10-12 cm long; C-shaped cartilage ringsET tube placement; suctioning depth
CarinaBifurcation of trachea into left and right mainstem bronchiET tube tip should be 3-5 cm above carina
Right mainstem bronchusShorter, wider, more vertical (25-degree angle)Most common aspiration site; right mainstem intubation
Left mainstem bronchusLonger, narrower, more horizontal (45-degree angle)Less common intubation/aspiration site
BronchiolesSmall airways without cartilage; smooth muscle wallsBronchospasm site (asthma, COPD)
Terminal bronchiolesLast conducting airway generationEnd of dead space ventilation
Alveoli~300 million; site of gas exchangeType I cells: gas exchange; Type II cells: surfactant production

Assessment of Respiratory Distress vs. Failure

Distinguishing between respiratory distress and impending respiratory failure is critical for determining intervention urgency.

Signs of Respiratory Distress (the patient is compensating):

  • Tachypnea (RR > 20 in adults)
  • Accessory muscle use (sternocleidomastoid, scalene, intercostal)
  • Nasal flaring
  • Intercostal and suprasternal retractions
  • Diaphoresis
  • Inability to speak in full sentences
  • Tachycardia
  • Agitation and anxiety
  • Tripod positioning (sitting upright, leaning forward, arms braced)

Signs of Impending Respiratory Failure (decompensation):

  • Altered mental status (confusion, somnolence, unresponsiveness)
  • Paradoxical breathing (abdomen rises while chest falls during inspiration)
  • Bradycardia (ominous sign in respiratory distress)
  • Central cyanosis (lips, mucous membranes)
  • Exhaustion, unable to maintain respiratory effort
  • Bradypnea or apnea
  • Silent chest (no air movement despite respiratory effort)

Mallampati Classification

The Mallampati score predicts intubation difficulty based on pharyngeal visualization:

ClassVisualizationIntubation Difficulty
Class ISoft palate, fauces, uvula, anterior and posterior pillars visibleEasy intubation expected
Class IISoft palate, fauces, uvula visibleUsually straightforward
Class IIISoft palate, base of uvula visiblePotentially difficult
Class IVOnly hard palate visibleDifficult intubation expected
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Lower Airway Branching Structure
Test Your Knowledge

A patient is found unresponsive. What is the MOST common cause of upper airway obstruction?

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B
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D
Test Your Knowledge

The right mainstem bronchus is the most common site for aspiration because it is:

A
B
C
D
Test Your Knowledge

Which of the following is a sign of impending respiratory FAILURE rather than respiratory distress?

A
B
C
D
Test Your KnowledgeFill in the Blank

The _____ cartilage is the only complete cartilage ring in the airway and serves as a landmark for cricothyrotomy.

Type your answer below