Key Takeaways

  • The heart has four chambers: right atrium, right ventricle, left atrium, and left ventricle, with the left ventricle being the strongest chamber
  • The cardiac conduction system follows the pathway: SA node -> AV node -> Bundle of His -> bundle branches -> Purkinje fibers
  • The right coronary artery (RCA) supplies the right side of the heart and inferior wall; the left anterior descending (LAD) supplies the anterior wall and septum
  • Cardiac output equals stroke volume multiplied by heart rate (CO = SV x HR), with a normal adult CO of approximately 5 liters per minute
  • Normal adult vital signs: heart rate 60-100 bpm, respiratory rate 12-20 breaths/min, systolic BP 90-140 mmHg
  • The tricuspid valve separates the right atrium and ventricle; the mitral (bicuspid) valve separates the left atrium and ventricle
  • Deoxygenated blood returns to the heart via the superior and inferior vena cava and enters the right atrium
Last updated: February 2026

Cardiovascular Anatomy & Physiology

The cardiovascular system is responsible for circulating blood throughout the body, delivering oxygen and nutrients to tissues, and removing waste products. As an EMT, understanding this system is critical for recognizing and managing cardiac emergencies.

Heart Chambers and Valves

The heart is a four-chambered muscular organ roughly the size of a fist, located in the mediastinum (center of the chest), slightly left of the midline.

ChamberFunctionBlood Type
Right AtriumReceives deoxygenated blood from the bodyDeoxygenated
Right VentriclePumps blood to the lungsDeoxygenated
Left AtriumReceives oxygenated blood from the lungsOxygenated
Left VentriclePumps blood to the entire bodyOxygenated

The heart has four valves that prevent backflow of blood:

  • Tricuspid valve - Between right atrium and right ventricle (3 leaflets)
  • Pulmonary (semilunar) valve - Between right ventricle and pulmonary artery
  • Mitral (bicuspid) valve - Between left atrium and left ventricle (2 leaflets)
  • Aortic (semilunar) valve - Between left ventricle and aorta

Memory tip: Tricuspid is on the Right (both have the letter "R" in the word "tRicuspid"). The mitral valve is also called the bicuspid valve because it has 2 leaflets.

Great Vessels

VesselRole
Superior vena cavaReturns deoxygenated blood from the upper body to the right atrium
Inferior vena cavaReturns deoxygenated blood from the lower body to the right atrium
Pulmonary arteriesCarry deoxygenated blood from the right ventricle to the lungs
Pulmonary veinsReturn oxygenated blood from the lungs to the left atrium
AortaCarries oxygenated blood from the left ventricle to the body

Key concept: The pulmonary arteries are the only arteries in the body that carry deoxygenated blood, and the pulmonary veins are the only veins that carry oxygenated blood.

Blood Flow Through the Heart

Blood flows through the heart in a specific sequence:

  1. Deoxygenated blood enters the right atrium via the superior and inferior vena cava
  2. Blood passes through the tricuspid valve into the right ventricle
  3. The right ventricle pumps blood through the pulmonary valve into the pulmonary arteries
  4. Blood travels to the lungs for gas exchange (CO2 released, O2 absorbed)
  5. Oxygenated blood returns to the left atrium via the pulmonary veins
  6. Blood passes through the mitral valve into the left ventricle
  7. The left ventricle pumps blood through the aortic valve into the aorta
  8. Oxygenated blood is distributed to the entire body

Cardiac Conduction System

The heart has its own intrinsic electrical system that controls the heartbeat. This is why the heart can continue to beat even when disconnected from the nervous system.

StructureFunctionRate (intrinsic)
SA node (sinoatrial)Primary pacemaker, located in the right atrium60-100 bpm
AV node (atrioventricular)Delays signal to allow atrial filling, located between atria and ventricles40-60 bpm
Bundle of HisConducts impulse from AV node to bundle branches40-60 bpm
Bundle branchesRight and left branches carry impulse down the interventricular septum20-40 bpm
Purkinje fibersDistribute impulse throughout the ventricles, causing contraction20-40 bpm

The conduction pathway: SA node -> AV node -> Bundle of His -> Bundle branches -> Purkinje fibers

Coronary Arteries

The heart muscle (myocardium) requires its own blood supply through the coronary arteries:

ArteryRegion Supplied
Left main coronary arteryBranches into LAD and circumflex
Left anterior descending (LAD)Anterior wall of left ventricle, interventricular septum
Left circumflex arteryLateral and posterior walls of left ventricle
Right coronary artery (RCA)Right ventricle, inferior wall, SA node (in ~60% of people), AV node

The LAD is sometimes called the "widowmaker" because blockage of this artery can cause a massive heart attack affecting a large portion of the left ventricle.

Cardiac Output

Cardiac output (CO) is the amount of blood pumped by the heart per minute:

CO = Stroke Volume (SV) x Heart Rate (HR)

  • Stroke volume = amount of blood pumped per beat (average ~70 mL in adults)
  • Heart rate = beats per minute
  • Normal CO = ~70 mL x 72 bpm = ~5,040 mL/min (~5 L/min)

Factors that affect cardiac output:

  • Preload - Volume of blood returning to the heart (stretching of ventricles)
  • Afterload - Resistance the heart must pump against (primarily arterial BP)
  • Contractility - Strength of cardiac muscle contraction

Normal Vital Signs by Age

Age GroupHeart Rate (bpm)Respiratory RateSystolic BP (mmHg)
Newborn120-16030-6060-80
Infant (1-12 mo)100-16025-5070-95
Toddler (1-3 yr)90-15020-3080-100
Preschool (4-5 yr)80-14020-2580-110
School-age (6-12 yr)70-12015-2085-120
Adolescent (13-18 yr)60-10012-2090-130
Adult60-10012-2090-140
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Blood Flow Through the Heart
Test Your Knowledge

Which valve separates the left atrium from the left ventricle?

A
B
C
D
Test Your Knowledge

What is the correct order of the cardiac conduction system?

A
B
C
D
Test Your Knowledge

Which coronary artery is commonly referred to as the "widowmaker"?

A
B
C
D
Test Your Knowledge

A patient has a stroke volume of 70 mL and a heart rate of 80 bpm. What is their cardiac output?

A
B
C
D
Test Your Knowledge

Which of the following is unique about the pulmonary arteries?

A
B
C
D
Test Your Knowledge

What is the normal resting heart rate range for an adult?

A
B
C
D
Test Your KnowledgeOrdering

Arrange the structures of the cardiac conduction system in the correct order of electrical impulse travel:

Arrange the items in the correct order

1
Bundle branches
2
AV node
3
SA node
4
Purkinje fibers
5
Bundle of His
Test Your KnowledgeMatching

Match each heart valve to its correct anatomical location:

Match each item on the left with the correct item on the right

1
Tricuspid valve
2
Mitral (bicuspid) valve
3
Pulmonary valve
4
Aortic valve