Key Takeaways

  • Radiology codes (70010-79999) cover diagnostic imaging, radiation oncology, and nuclear medicine, and can be billed globally or split into professional (-26) and technical (-TC) components.
  • Supervision and interpretation (S&I) codes are used when the physician provides oversight of a procedure and interprets the images, often reported in addition to the surgical procedure code.
  • Radiology procedures require a written report (interpretation) to bill the professional component — verbal communication alone is insufficient.
  • CT, MRI, and ultrasound codes are differentiated by anatomical site, use of contrast (without, with, or without followed by with), and number of sequences.
  • Pathology codes (80047-89398) are divided into clinical pathology (lab tests on body fluids) and anatomic pathology (tissue examination), each with distinct coding rules.
  • Surgical pathology (88300-88309) is coded based on the level of examination: from gross examination only (Level I) to complex specimens requiring extensive microscopic analysis (Level VI).
  • Clinical chemistry panels (80047-80081) are predefined groups of tests — all component tests must be performed to report the panel code; missing any component requires individual test codes.
  • Drug testing codes distinguish between presumptive (screening) and definitive (confirmatory) testing, each with separate code ranges.
Last updated: February 2026

Radiology & Pathology/Laboratory Coding

Radiology and pathology are two distinct CPT sections that CPC candidates must understand. While they differ in clinical focus, both share the concept of component billing and require attention to specific coding conventions.


Radiology Coding (70010-79999)

Radiology Subsections

SubsectionCode RangeExamples
Diagnostic Radiology70010-76499X-rays, CT scans, MRI, fluoroscopy
Diagnostic Ultrasound76506-76999Ultrasound imaging
Radiologic Guidance77001-77022Fluoroscopic, CT, MRI guidance for procedures
Breast Mammography77046-77067Screening and diagnostic mammography
Bone/Joint Studies77071-77086DEXA scans, bone density
Radiation Oncology77261-77799Treatment planning, radiation delivery
Nuclear Medicine78012-79999PET scans, thyroid uptake, cardiac imaging

Component Billing (Professional vs. Technical)

Most radiology procedures have two billable components:

ComponentWho ProvidesWhat's IncludedModifier
ProfessionalPhysician/radiologistInterpretation, written report, clinical judgment-26
TechnicalFacility/imaging centerEquipment, supplies, technician, room-TC
GlobalOne entity provides bothBoth professional and technicalNo modifier

Example Scenario:

  • Patient gets a chest X-ray at an independent imaging center where the radiologist is employed → Global billing (no modifier)
  • Patient gets a chest X-ray at a hospital, and an outside radiologist interprets it → Hospital bills -TC, radiologist bills -26

Contrast Designations

Imaging studies are coded based on contrast usage:

DesignationMeaningExample Code Structure
Without contrastNo contrast material administeredCT abdomen without contrast
With contrastContrast material administeredCT abdomen with contrast
Without, followed by with contrastBoth sequences performedCT abdomen without contrast, followed by with contrast

Key Rule: "Without followed by with" is a SEPARATE code from "without" or "with" alone — do NOT report two separate codes for each phase.

Supervision and Interpretation (S&I)

Some surgical procedures involve radiologic guidance. In these cases:

  • The surgical procedure is coded from the Surgery section
  • The radiologic supervision and interpretation (S&I) is coded from the Radiology section
  • Both codes may be reported if the physician performs both the procedure AND the S&I
  • If different physicians perform the procedure and the S&I, each bills their respective code

Example: A physician performs a lumbar puncture with fluoroscopic guidance:

  • 62270 (Lumbar puncture) + 77003 (Fluoroscopic guidance for needle placement)

Pathology & Laboratory Coding (80047-89398)

Major Pathology Subsections

SubsectionCode RangeDescription
Organ/Disease Panels80047-80081Predefined groups of chemistry tests
Drug Assay80143-80377Therapeutic drug monitoring
Drug Testing80305-80377Presumptive and definitive drug screening
Chemistry82009-84999Individual clinical chemistry tests
Hematology85002-85999CBC, coagulation studies
Immunology86000-86849Antibody testing, immune function
Microbiology87003-87999Culture, sensitivity, infectious disease testing
Anatomic Pathology88000-88099Autopsy, postmortem exam
Cytopathology88104-88199Pap smears, fluid cytology
Surgical Pathology88300-88309Tissue examination (gross and microscopic)

Organ/Disease Panels

Panels are predefined groups of tests that must be performed in their entirety:

PanelCodeTests Included
Basic Metabolic Panel (BMP)80048Calcium, chloride, CO2, creatinine, glucose, potassium, sodium, BUN
Comprehensive Metabolic Panel (CMP)80053BMP + albumin, bilirubin, alkaline phosphatase, protein, ALT, AST
Lipid Panel80061Total cholesterol, HDL, triglycerides (LDL is calculated, not a component)
Hepatic Function Panel80076Albumin, bilirubin (total + direct), alkaline phosphatase, protein, ALT, AST

Key Rule: If all component tests of a panel are performed, report the panel code. If even one test is missing, you cannot report the panel — report each individual test code instead. If additional tests beyond the panel are performed, report the panel code PLUS the individual codes for the extra tests.

Surgical Pathology Levels (88300-88309)

Surgical pathology is coded based on the level of examination required:

LevelCodeExamination TypeExample Specimens
Level I88300Gross examination onlyN/A (any specimen examined only grossly)
Level II88302Gross and microscopicAppendix (incidental), fallopian tube (sterilization), foreskin (newborn)
Level III88304Gross and microscopicGallbladder, tonsils, hernia sac, uterus (prolapse)
Level IV88305Gross and microscopicBreast biopsy, colon biopsy, skin excision, lymph node biopsy, uterus (other than prolapse)
Level V88307Gross and microscopicColon (total resection), kidney (partial/total nephrectomy), adrenal (tumor resection)
Level VI88309Gross and microscopicBone marrow (tumor), colon (with tumor resection + lymph nodes), larynx (partial/total with tumor)

Key Rule: The level is determined by the specimen type, NOT by the pathologist's time or effort. CPT provides a detailed list of specimens assigned to each level. If the specimen is not listed, use the closest comparable level.

Drug Testing

TypeCode RangePurpose
Presumptive80305-80307Screening — identifies presence of drug class (e.g., immunoassay, dipstick)
Definitive80320-80377Confirmatory — identifies specific drug and quantity (e.g., mass spectrometry, chromatography)

Presumptive testing is typically a single code regardless of the number of drug classes tested. Definitive testing is coded per drug or drug metabolite identified.

Test Your Knowledge

A radiologist at a private practice interprets a CT scan of the abdomen that was performed at a hospital. How should the radiologist bill for the interpretation?

A
B
C
D
Test Your Knowledge

A physician orders a CT of the chest without contrast, followed by a CT of the chest with contrast. How should this be coded?

A
B
C
D
Test Your Knowledge

A physician orders a comprehensive metabolic panel (CMP) but the lab only performs 13 of the 14 required component tests. How should this be coded?

A
B
C
D
Test Your KnowledgeFill in the Blank

Surgical pathology Level IV is coded with CPT code _____.

Type your answer below

Test Your KnowledgeMatching

Match each radiology modifier to its correct meaning:

Match each item on the left with the correct item on the right

1
-26
2
-TC
3
No modifier
4
-59
Test Your KnowledgeMulti-Select

Which of the following are component tests included in the Basic Metabolic Panel (BMP, 80048)? (Select all that apply)

Select all that apply

Glucose
ALT (alanine aminotransferase)
Sodium
Creatinine
Albumin
Potassium
Test Your Knowledge

A surgical specimen of a gallbladder is sent to pathology for examination. What surgical pathology level is assigned?

A
B
C
D