Key Takeaways

  • The adult skeleton has 206 bones divided into axial (80) and appendicular (126) skeletons
  • Osteoblasts build bone; osteoclasts break down bone; osteocytes maintain bone
  • Three muscle types: skeletal (voluntary, striated), cardiac (involuntary, striated), smooth (involuntary, non-striated)
  • Tendons connect muscle to bone; ligaments connect bone to bone
  • Synovial joints are freely movable and contain synovial fluid for lubrication
Last updated: January 2026

The Musculoskeletal System

The musculoskeletal system provides structure, support, protection, and movement. It consists of bones, muscles, cartilage, tendons, ligaments, and joints.

Skeletal System Functions

FunctionDescription
SupportFramework for body structure
ProtectionShields vital organs (skull protects brain)
MovementProvides attachment points for muscles
Blood cell productionHematopoiesis in red bone marrow
Mineral storageStores calcium and phosphorus

Bone Classification

TypeShapeExamples
Long bonesLonger than wideFemur, humerus, phalanges
Short bonesRoughly cube-shapedCarpals, tarsals
Flat bonesThin, flatSkull, sternum, ribs, scapula
Irregular bonesComplex shapesVertebrae, pelvis
Sesamoid bonesEmbedded in tendonsPatella

Bone Structure

PartDescription
DiaphysisShaft of long bone
EpiphysisEnds of long bone
Epiphyseal plateGrowth plate (cartilage in children)
PeriosteumOuter membrane covering bone
Compact boneDense, hard outer layer
Spongy bonePorous inner layer with trabeculae
Medullary cavityCentral cavity containing marrow

Bone Cells

Cell TypeFunction
OsteoblastsBuild new bone (bone formation)
OsteocytesMaintain bone tissue
OsteoclastsBreak down bone (resorption)

Axial vs. Appendicular Skeleton

DivisionBonesCount
AxialSkull, vertebrae, ribs, sternum80 bones
AppendicularLimbs, shoulder girdle, pelvic girdle126 bones
Total206 bones (adult)

Joint Types

TypeMovementExamples
FibrousImmovableSkull sutures
CartilaginousSlightly movableVertebral discs, pubic symphysis
SynovialFreely movableKnee, elbow, shoulder, hip

Synovial Joint Features

FeatureFunction
Articular cartilageReduces friction between bones
Synovial membraneProduces synovial fluid
Synovial fluidLubricates joint
Joint capsuleEncloses joint
LigamentsConnect bone to bone

Muscle Types

TypeLocationControlAppearance
SkeletalAttached to bonesVoluntaryStriated
CardiacHeartInvoluntaryStriated
SmoothOrgans, blood vesselsInvoluntaryNon-striated

Muscle Structure

ComponentDescription
MuscleEntire organ
FascicleBundle of muscle fibers
Muscle fiberSingle muscle cell
MyofibrilContractile units within fiber
SarcomereBasic unit of contraction

Muscle Contraction

Sliding Filament Theory:

  1. Nerve impulse triggers calcium release
  2. Calcium exposes binding sites on actin
  3. Myosin heads attach to actin (cross-bridges)
  4. Myosin pulls actin, sliding filaments together
  5. Sarcomere shortens → muscle contracts

Key proteins:

  • Actin: Thin filaments
  • Myosin: Thick filaments with heads

Key Connective Tissues

TissueConnects
TendonsMuscle to bone
LigamentsBone to bone
CartilageCushions joints, provides flexibility
Test Your Knowledge

Which bone cells are responsible for breaking down bone tissue?

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D
Test Your Knowledge

Which type of muscle tissue is found in the walls of blood vessels?

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B
C
D
Test Your Knowledge

What connects muscle to bone?

A
B
C
D