Key Takeaways

  • Medical terms are built from four components: word roots, prefixes, suffixes, and combining vowels.
  • The word root is the foundation of every medical term and identifies the body part or structure involved.
  • A combining vowel (usually "o") is used between a word root and a suffix that begins with a consonant to make the term easier to pronounce.
  • Prefixes modify the meaning of the root by indicating location, number, time, or status (e.g., "hyper-" means excessive, "sub-" means under).
  • Suffixes indicate the condition, procedure, or disease associated with the root (e.g., "-itis" means inflammation, "-ectomy" means surgical removal).
  • Understanding word parts allows coders to decode unfamiliar medical terms without memorizing every individual word.
  • Directional terms such as superior, inferior, anterior, posterior, medial, and lateral are essential for understanding operative reports.
  • Body planes (sagittal, coronal/frontal, transverse) and body cavities (thoracic, abdominal, pelvic, cranial) are frequently referenced in coding documentation.
Last updated: February 2026

Medical Terminology Foundations

Medical terminology is the specialized language of healthcare. For CPC coders, understanding medical terms is not optional — it is the foundation of accurate code assignment. Every operative report, progress note, and diagnosis description uses these terms. Knowing how to break down and analyze unfamiliar terms is a critical skill on the CPC exam.


Building Blocks of Medical Terms

Medical terms are constructed from four key components:

1. Word Roots

The word root is the core of every medical term. It identifies the body part, organ, or structure being referenced.

Word RootMeaningExample Term
cardi/oHeartCardiology (study of the heart)
gastr/oStomachGastritis (inflammation of the stomach)
arthr/oJointArthroscopy (visual examination of a joint)
dermat/oSkinDermatitis (inflammation of the skin)
oste/oBoneOsteoporosis (porous bone condition)
nephr/oKidneyNephrectomy (surgical removal of a kidney)
pulmon/oLungPulmonary (pertaining to the lungs)
neur/oNerveNeurology (study of the nervous system)
hepat/oLiverHepatitis (inflammation of the liver)
my/oMuscleMyalgia (muscle pain)

2. Combining Vowels

A combining vowel (almost always the letter "o") links a word root to a suffix or to another word root. The combining vowel is used when the suffix begins with a consonant.

Rules:

  • Use a combining vowel between a word root and a suffix that starts with a consonant: gastr + o + scope = gastroscope
  • Do NOT use a combining vowel when the suffix begins with a vowel: gastr + itis = gastritis (not "gastroitis")
  • Use a combining vowel between two word roots, regardless of the second root's starting letter: gastr + o + enter + itis = gastroenteritis

3. Prefixes

Prefixes are added to the beginning of a term to modify its meaning. They indicate location, time, number, or status.

PrefixMeaningExample
hyper-Excessive, aboveHypertension (high blood pressure)
hypo-Deficient, belowHypoglycemia (low blood sugar)
sub-Under, beneathSubcutaneous (under the skin)
supra-AboveSuprapubic (above the pubic bone)
peri-AroundPericardium (membrane around the heart)
inter-BetweenIntercostal (between the ribs)
intra-WithinIntravenous (within a vein)
bi-TwoBilateral (both sides)
uni-OneUnilateral (one side)
poly-ManyPolyuria (excessive urination)
dys-Difficult, painfulDyspnea (difficulty breathing)
a-/an-Without, absenceApnea (absence of breathing)
anti-AgainstAntibiotic (against bacteria)
pre-BeforePrenatal (before birth)
post-AfterPostoperative (after surgery)

4. Suffixes

Suffixes are added to the end of a word root (with or without a combining vowel) to indicate a condition, procedure, or diagnostic test.

SuffixMeaningExample
-itisInflammationAppendicitis (inflammation of the appendix)
-ectomySurgical removalCholecystectomy (removal of the gallbladder)
-otomyCutting into / incisionTracheotomy (incision into the trachea)
-ostomyCreating an openingColostomy (creating an opening in the colon)
-plastySurgical repairRhinoplasty (surgical repair of the nose)
-scopyVisual examinationColonoscopy (visual examination of the colon)
-graphyProcess of recordingMammography (imaging of the breast)
-gramRecord/imageElectrocardiogram (heart rhythm recording)
-ologyStudy ofPathology (study of disease)
-algiaPainNeuralgia (nerve pain)
-osisAbnormal conditionStenosis (abnormal narrowing)
-emiaBlood conditionAnemia (deficient blood/hemoglobin)
-pathyDiseaseNeuropathy (nerve disease)
-megalyEnlargementCardiomegaly (enlarged heart)
-rrhage/-rrhagiaBursting forth (bleeding)Hemorrhage (excessive bleeding)

Anatomical Directional Terms

Understanding directional terms is critical for reading operative reports and assigning codes with correct laterality and anatomical specificity.

TermMeaningOpposite
Superior (cranial)Toward the head / upperInferior (caudal) — toward the feet / lower
Anterior (ventral)Toward the frontPosterior (dorsal) — toward the back
MedialToward the midlineLateral — away from the midline
ProximalCloser to the trunk/originDistal — farther from the trunk/origin
SuperficialNear the surfaceDeep — away from the surface
IpsilateralSame sideContralateral — opposite side

Body Planes

Body planes are imaginary flat surfaces used to divide the body for anatomical reference and imaging:

PlaneDivisionUsed In
Sagittal (lateral)Divides body into left and right halvesMRI scans, neurological imaging
Coronal (frontal)Divides body into anterior and posterior portionsChest X-rays, coronal CT reconstructions
Transverse (horizontal/axial)Divides body into superior and inferior portionsCT scans (standard axial slices)

Body Cavities

CavityContentsCoding Relevance
CranialBrainNeurosurgery codes (CPT 61000-62258)
SpinalSpinal cordSpine surgery codes (CPT 63001-63308)
ThoracicHeart, lungs, great vesselsCardiothoracic surgery, chest codes
AbdominalStomach, liver, intestines, kidneysDigestive system surgery codes
PelvicBladder, reproductive organs, rectumUrinary and genital system codes
Test Your Knowledge

The medical term "cholecystectomy" can be broken down into which components?

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B
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D
Test Your Knowledge

When is a combining vowel used in building a medical term?

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B
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D
Test Your KnowledgeMatching

Match each medical prefix to its correct meaning:

Match each item on the left with the correct item on the right

1
hyper-
2
sub-
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peri-
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intra-
5
dys-
Test Your KnowledgeFill in the Blank

The suffix "-ectomy" means surgical _____ of a body part.

Type your answer below

Test Your Knowledge

A surgeon documents that a lesion is on the "anterior lateral aspect of the right lower extremity." Where is the lesion located?

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D
Test Your Knowledge

The transverse (axial) plane divides the body into which two portions?

A
B
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D
Test Your KnowledgeMulti-Select

Which of the following suffixes indicate a SURGICAL PROCEDURE? (Select all that apply)

Select all that apply

-ectomy (surgical removal)
-algia (pain)
-plasty (surgical repair)
-osis (abnormal condition)
-otomy (cutting into / incision)
-emia (blood condition)