Key Takeaways

  • A hematoma (bruise) is the most common complication of venipuncture — caused by blood leaking into surrounding tissue from a punctured vein
  • Syncope (fainting) is managed by stopping the draw, removing the needle, applying pressure, lowering the patient's head, and applying a cold compress to the forehead or back of the neck
  • Nerve injury presents as sharp, shooting, electric-like pain radiating down the arm — IMMEDIATELY stop the draw and remove the needle
  • Petechiae (small red dots on the skin) appearing above the tourniquet site indicate a possible platelet disorder or fragile capillaries
  • If a venipuncture is unsuccessful after TWO attempts, the phlebotomist must ask another qualified person to attempt the draw
  • Hemolysis (rupture of red blood cells) is caused by using a needle that is too small, pulling the syringe plunger too fast, shaking tubes, or forcing blood through a small needle
  • An accidental arterial puncture is identified by bright red, pulsating blood — apply firm pressure for at least 5 minutes and do NOT apply a tourniquet
  • If a vein collapses during blood draw, try releasing the tourniquet slightly, reducing vacuum (use a smaller tube or syringe), or repositioning the needle slightly
Last updated: February 2026

Difficult Draws & Complications

Even experienced phlebotomists encounter difficult draws and complications. Knowing how to prevent, recognize, and manage these situations is essential for patient safety and specimen quality.


Common Complications

1. Hematoma (Most Common Complication)

A hematoma is a bruise caused by blood leaking from the vein into surrounding tissue.

Causes:

  • Needle inserted through both walls of the vein
  • Needle partially in the vein
  • Tourniquet left on too long
  • Inadequate pressure applied after needle removal
  • Fragile or small veins

Prevention:

  • Use proper needle insertion technique (15-30 degree angle)
  • Anchor the vein well before puncture
  • Apply firm pressure for 3-5 minutes after the draw
  • Do not bend the arm after the draw — this does NOT help and can worsen bleeding

Management:

  • If a hematoma forms during the draw: immediately remove the needle, apply firm pressure, and elevate the arm
  • Apply cold compress for 15-20 minutes to reduce swelling
  • Document the occurrence

2. Syncope (Fainting)

Signs of impending syncope:

  • Lightheadedness, dizziness
  • Pale, cool, clammy skin
  • Nausea
  • Tunnel vision or loss of vision

Management:

  1. Stop the draw immediately and remove the needle safely
  2. Apply pressure to the puncture site
  3. If seated: lower the patient's head between their knees (or recline the chair)
  4. If supine: elevate the legs
  5. Apply cold compress to the forehead or back of the neck
  6. Loosen tight clothing
  7. Use ammonia inhalants (smelling salts) if available — wave under the nose, do NOT hold directly against the nostrils
  8. Never leave a fainting patient unattended
  9. Document the incident

3. Nerve Injury

Signs:

  • Sharp, shooting, electric-like pain radiating down the arm or into the fingers
  • Numbness or tingling
  • This is DIFFERENT from the normal brief sting of needle insertion

Management:

  • IMMEDIATELY remove the needle — do NOT redirect or reposition
  • Apply pressure to the site
  • Document the incident and notify the patient's physician
  • Nerve injuries can result in long-term pain, numbness, or loss of function

4. Hemolysis (Red Blood Cell Destruction)

Hemolysis is the #1 cause of specimen rejection in laboratories.

Causes of hemolysis:

CauseExplanation
Needle too smallForces blood through a small opening, damaging cells
Pulling syringe plunger too fastCreates excessive shear force on cells
Shaking tubesMechanical destruction of cells (always INVERT, never shake)
Forcing blood through a small needleSyringe transfer through narrow gauge damages cells
Drawing from a hematomaDamaged cells from the hematoma contaminate the specimen
Using alcohol that hasn't driedResidual alcohol hemolysis cells on contact
Prolonged tourniquet applicationCauses stasis and cell damage
Vigorous mixing of tubesRough handling destroys fragile cells

Visual Sign: Hemolyzed serum/plasma appears pink to red (cherry-colored) instead of the normal straw-yellow color.

5. Accidental Arterial Puncture

Signs:

  • Bright red blood (vs. dark red/maroon for venous blood)
  • Pulsating blood flow — tube fills rapidly
  • Patient may report unusual pain

Management:

  • Remove the needle immediately
  • Apply firm, direct pressure for at least 5 minutes (longer than venous bleeding)
  • Do NOT apply a tourniquet — this can worsen bleeding
  • Monitor the site after pressure release
  • Document and report the incident

6. Petechiae

Petechiae are tiny, pinpoint red spots that appear on the skin (often above the tourniquet site).

Causes:

  • Tourniquet too tight or applied too long
  • Platelet disorders (thrombocytopenia)
  • Fragile capillaries (common in elderly patients or those on anticoagulants)

The Two-Attempt Rule

Most facilities follow a two-attempt rule:

  • If a phlebotomist is unsuccessful after two venipuncture attempts, they must stop and ask another qualified phlebotomist to try
  • Making more than two attempts increases patient discomfort, anxiety, and risk of complications
  • Document all failed attempts
  • Never attempt a draw more than twice on the same patient

Failed Venipuncture: Troubleshooting

ProblemPossible CauseSolution
No blood flowNeedle not in veinReposition slightly; do NOT probe excessively
Blood stops flowingVein collapsed, needle movedRelease tourniquet briefly, use smaller tube, reposition
Slow blood flowSmall vein, needle partially in veinEnsure bevel is fully in the vein; try a smaller tube
Blood leaking around needleNeedle through both wallsRemove needle; apply pressure; try another site
Tube not fillingLoss of vacuum; tube expiredTry a new tube; check expiration date

Vein Assessment Techniques

Proper vein assessment is a critical skill that improves first-stick success rates:

Palpation Technique

  • Always use your index finger for palpation — NEVER your thumb (your thumb has its own pulse and you may confuse it with an artery)
  • A healthy vein feels bouncy, resilient, and spongy — it compresses when pressed and rebounds when released
  • An artery pulsates rhythmically — never puncture a pulsating vessel
  • A tendon feels hard, cord-like, and does NOT rebound — tendons do not contain blood

Difficult-to-Find Veins

For patients with difficult-to-find veins, try these techniques:

TechniqueHow It Helps
Warm the areaApply a warm towel for 3-5 minutes to dilate veins
Lower the armHang the arm below heart level to increase venous filling
Gently tap the veinLight tapping stimulates vein dilation
Apply tourniquetRestricts venous flow, causing veins to engorge
Ask patient to make a fistSqueezing (NOT pumping) increases vein prominence
Use a vein finderInfrared or near-infrared device to visualize veins through the skin
Try a blood pressure cuffInflate to diastolic pressure for more controlled venous engorgement

Veins vs. Arteries vs. Tendons

CharacteristicVeinArteryTendon
FeelBouncy, resilient, spongyPulsating, firmHard, cord-like
ColorBluish (visible through skin)Not usually visibleNot colored
CompressionCompresses easily; reboundsRebounds forcefullyDoes not compress
LocationSuperficial to deepUsually deeper than veinsAlong bones and joints
Blood flowToward heartAway from heartN/A

Documentation

Proper documentation is essential for every blood collection. The phlebotomist should document:

  • Patient identification verification
  • Date and time of collection
  • Tests ordered and tubes collected
  • Site used (e.g., right median cubital, left hand dorsal)
  • Number of attempts (including failed attempts)
  • Complications (hematoma, syncope, nerve pain, refusal)
  • Disposition — specimen sent to lab, transported by (method)
  • Phlebotomist signature/ID

Incident Reporting

  • Any adverse event (needlestick, patient injury, syncope, nerve pain) must be documented in an incident report
  • Include: date, time, description of event, patient and staff involved, actions taken, and follow-up plan
  • Incident reports are used for quality improvement and are NOT punitive documents

Anticoagulant Therapy and Phlebotomy Considerations

Many patients seen by phlebotomists are on anticoagulant therapy. Understanding these medications helps ensure safe blood collection:

MedicationBrand Name(s)MechanismLab MonitoringPhlebotomy Impact
WarfarinCoumadinInhibits vitamin K-dependent clotting factorsPT/INRApply extended pressure (5+ min); monitor for hematoma
Heparin (unfractionated)Heparin IVInhibits thrombin and Factor XaaPTTApply extended pressure; draw from opposite arm of heparin drip
EnoxaparinLovenoxInhibits Factor XaAnti-Xa levels (special test)Apply extended pressure; subcutaneous injection sites may bruise easily
RivaroxabanXareltoDirect Factor Xa inhibitorUsually not monitoredApply extended pressure
ApixabanEliquisDirect Factor Xa inhibitorUsually not monitoredApply extended pressure
DabigatranPradaxaDirect thrombin inhibitorUsually not monitoredApply extended pressure
AspirinVariousInhibits platelet aggregationBleeding time (rarely)Apply extended pressure; may bruise easily
ClopidogrelPlavixInhibits platelet aggregationPlatelet function testsApply extended pressure

Critical Clinical Tip: Always ask patients if they are taking any blood thinners or anticoagulants before the draw. Apply firm pressure for at least 5 minutes (or longer) after the venipuncture to prevent hematoma formation. DO NOT apply a bandage until bleeding has completely stopped.

Relative Frequency of Venipuncture Complications (%)
Test Your Knowledge

What is the MOST COMMON complication of venipuncture?

A
B
C
D
Test Your Knowledge

During a venipuncture, the patient reports a sharp, shooting, electric-like pain radiating down their arm. The phlebotomist should:

A
B
C
D
Test Your Knowledge

Which of the following is the #1 cause of specimen rejection in laboratories?

A
B
C
D
Test Your KnowledgeMulti-Select

Which of the following can cause hemolysis of a blood specimen? (Select all that apply)

Select all that apply

Using a needle gauge that is too small
Gently inverting tubes after collection
Drawing blood through a hematoma site
Shaking tubes vigorously instead of inverting
Pulling the syringe plunger too rapidly
Allowing alcohol to air dry before venipuncture
Test Your Knowledge

A phlebotomist has made two unsuccessful venipuncture attempts on a patient. What should they do next?

A
B
C
D
Test Your Knowledge

Bright red, pulsating blood during a venipuncture most likely indicates:

A
B
C
D
Test Your KnowledgeFill in the Blank

After venipuncture, firm pressure should be applied to the puncture site for at least ___ minutes to prevent hematoma formation.

Type your answer below

Test Your Knowledge

A patient begins to feel lightheaded and nauseated during a blood draw. The phlebotomist's FIRST action should be:

A
B
C
D
Test Your KnowledgeMatching

Match each venipuncture complication to its primary identifying sign:

Match each item on the left with the correct item on the right

1
Hematoma
2
Nerve injury
3
Arterial puncture
4
Syncope
Test Your Knowledge

A patient on warfarin (Coumadin) has blood drawn. How long should the phlebotomist hold pressure after removing the needle?

A
B
C
D
Test Your Knowledge

While palpating for a vein, the phlebotomist feels a structure that pulsates rhythmically. This structure is most likely:

A
B
C
D
Test Your KnowledgeFill in the Blank

The phlebotomist should always use their _____ finger (not their thumb) to palpate veins.

Type your answer below

Test Your Knowledge

During a venipuncture, the blood suddenly stops flowing into the tube. Which of the following is the MOST appropriate first action?

A
B
C
D
Test Your Knowledge

Which of the following patients requires PHYSICIAN AUTHORIZATION before drawing blood from a foot vein?

A
B
C
D
Test Your KnowledgeMulti-Select

Which of the following techniques can help locate veins in a patient with difficult-to-find veins? (Select all that apply)

Select all that apply

Apply a warm towel to the area for 3-5 minutes
Lower the arm below heart level
Gently tap the vein to stimulate dilation
Apply the tourniquet tighter and leave it on longer
Ask the patient to pump their fist vigorously
Use a vein-finding device (infrared)